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The Association between Cyclin D1 (CCND1) rs9344 AA Genotype and Increased Risk of Colorectal Cancer in An Iranian Population | ||
| Middle East Journal of Cancer | ||
| دوره 11، شماره 3 - شماره پیاپی 43، مهر 2020، صفحه 360-364 اصل مقاله (104.69 K) | ||
| نوع مقاله: Brief Communication | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2020.81432.1006 | ||
| نویسندگان | ||
| Shima Rahimirad1؛ Meysam Mosallaei2؛ Rasoul Salehi* 2؛ Shervin Shariatpanahi2؛ Ahmad Reza Salehi2 | ||
| 1Faculty of Sciences, University of Shahrekord, Shahrekord, Iran | ||
| 2Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| چکیده | ||
| Background: Colorectal cancer (CRC) is a globally growing disease with a steady decrease in the age of incidence. Pathogenesis of this cancer stems from a complex interaction between environmental factors and genetic predisposition. Among genetic factors, high activity of cyclin D1gene is prominent. A polymorphism (G870A) in exon 4 of cyclin D1 is responsible for a variant transcript with longer half-life and may culminate in uncontrollable cellular growth, thereby contributing to cancer development. Method: This case-control study evaluated the frequency of CCND1 G870A polymorphism and risk of sporadic CRC in an Iranian population. The study population comprised 50 CRC patients and 50 CRC-free controls selected on the basis of colonoscopy examination. For genotyping, we performed polymerase chain reaction – restriction fragment length polymorphism analysis (PCR-RFLP). Result: AA genotype frequencies compared to GA+GG genotype frequencies between cases and controls showed that AA genotype frequency in the case group was significantly higher than the control group (AA vs. GG + GA: OR= 2.25, 95% CI: 1.13-5.54, P=0.04). Allele A frequency was 57% in patients and 46% in healthy subjects. Statistical analysis showed that the odds ratio of carriers with allele A for risk of CRC was 1.55 more than G allele carriers (OR=1.55, 95% CI: 0.856-2.828). Moreover, physical activity in cases was significantly less than controls (P=0.001). We further observed that the subjects in the case group used fewer non-steroidal antiinflammatory drugs compared to healthy controls (P=0.02). Analysis of body mass index (BMI) between cases and controls revealed that the average of BMI in cases was higher than the controls (P =0.04). Conclusion: Our results showed that individuals carrying the AA genotype ran a higher risk of developing CRC compared to GG genotype. | ||
| کلیدواژه‌ها | ||
| Colorectal cancer؛ Single nucleotide polymorphism؛ Cyclin D1 gene | ||
| اصل مقاله | ||
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How to cite this article: Rahimirad Sh, Mosallaei M, Salehi R, Shariatpanahi Sh, Salehi AR. The association between cyclin D1 (CCND1) rs9344 AA genotype and increased risk of colorectal cancer in an Iranian population. Middle East J Cancer. 2020;11(3):360-364. doi: 10.30476/mejc.2020.81432.1006 | ||
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