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Ho, Yiu, Hoff, Jai, May, Andrew, Renwick, Clay. (1399). Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery. سامانه مدیریت نشریات علمی, 8(2), 75-78. doi: 10.30476/acrr.2020.46702
Yiu Ming Ho; Jai Hoff; Andrew May; Clay Renwick. "Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery". سامانه مدیریت نشریات علمی, 8, 2, 1399, 75-78. doi: 10.30476/acrr.2020.46702
Ho, Yiu, Hoff, Jai, May, Andrew, Renwick, Clay. (1399). 'Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery', سامانه مدیریت نشریات علمی, 8(2), pp. 75-78. doi: 10.30476/acrr.2020.46702
Ho, Yiu, Hoff, Jai, May, Andrew, Renwick, Clay. Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery. سامانه مدیریت نشریات علمی, 1399; 8(2): 75-78. doi: 10.30476/acrr.2020.46702

Distal Margin Shrinkage Factor – A Consideration Before Dividing the Specimen in Colorectal Cancer Surgery

Iranian Journal of Colorectal Research
مقاله 3، دوره 8، شماره 2، شهریور 2020، صفحه 75-78    اصل مقاله (520.7 K)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2020.46702
نویسندگان
Yiu Ming Ho1؛ Jai Hoff* 2؛ Andrew May2؛ Clay Renwick2
1Department of Digestive Diseases, Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE, United Kingdom
2Surgical Department, Rockhampton Hospital, Rockhampton
چکیده
Background - The risk of local recurrence in colorectal cancer has been associated with the length of clear distal margin in the specimen taken during original resection. It has been reported that there is significant specimen shrinkage after fixation in formalin. This study is aimed to quantify this degree of shrinkage and to investigate the factors for specimen shrinkage.
Methods – This research was a single centre prospective study. All adult patients who underwent colorectal surgery for cancer had demographics, surgical details and cancer staging and pathology recorded. Colonic specimens were measured immediately post resection including the total length, the mesenteric length and the distal length from the palpable tumour. Multiple logistic linear regression was applied to identify factors associated with distal margin shrinkage.
Results – Right-sided colectomy specimens had an inconsistent degree of shrinkage. Left-sided colectomy specimens showed an average shrinkage of 20% (CI 4% – 36%). The only other factor observed that had statistically significant association on the shrinkage of distal margins in specimens was increasing tumour size.
Conclusions - Specimens resected during anterior resection for colorectal cancer have a consistent level of shrinkage. Locally advanced tumours were observed to have an association with specimen distal margin shrinkage, however the mechanism is unclear. This new evidence can assist intra-operative decision making to allow adequate distal margin resection.
کلیدواژه‌ها
Colorectal neoplasm؛ colorectal surgery؛ formalin؛ margins of excision
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مراجع
  1. Monson JR, Weiser MR, Buie WD, Chang GJ, Rafferty JF, Buie WD, Rafferty J. Practice parameters for the management of rectal cancer (revised). Dis Colon Rectum 2013; 56:535.
  2. Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, Miedema B, Ota D, Sargent D. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 2001; 93:583.
  3. Sjövall A, Granath F, Cedermark B, Glimelius B, Holm T. Loco-regional recurrence from colon cancer: a population-based study. Ann Surg Oncol 2007; 14:432.
  4. Kim YW, Kim NK, Min BS, et al. Factors associated with anastomotic recurrence after total mesorectal excision in rectal cancer patients. J Surg Oncol 2009; 99:58.
  5. Nelson H, Petrelli N, Carlin A. National Cancer Institute Expert Panel. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst. 2001;93:583–96.
  6. Goldstein NS, Soman A, Sacksner J. Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage. Am J Clin Pathol. 1999 Mar;111(3):349-51.
  7. Luo Y, Wang P, Liang J, Ye J, Tan M, Luo P, Luo J, Huang M. Tubeless natural orifice specimen extraction surgery in Rectosigmoid Cancers - a video vignette. Colorectal Dis. 2019 Aug
  8. Nash GM, Weiss A, Dasgupta R, Gonen M, Guillem JG, Wong WD. Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection. Dis Colon Rectum. 2010 Oct;53(10):1365-73.
  9. Vernava AMI, Moran M, Rothenberger. A prospective evaluation of distal margins in carcinoma of the rectum. Surg Gynecol Obstet. 1992;175:333-6.
  10. Heald RJ, Karanjia ND. Results of radical surgery for rectal cancer. World J Surg. 1992 Sep-Oct;16(5):848-57.
  11. Hong KS, Moon N, Chung SS, Lee RA, Kim KH. Oncologic outcomes in rectal cancer with close distal resection margins: a retrospective analysis. Ann Surg Treat Res. 2015 Jul;89(1):23-9.
  12. Bujko K, Rutkowski A, Chang GJ, Michalski W, Chmielik E, Kusnierz J. Is the 1-cm rule of distal bowel resection margin in rectal cancer based on clinical evidence? A systematic review. Ann Surg Oncol. 2012 Mar;19(3):801-8.
  13. Kang DW, Kwak HD, Sung NS, Yang IS, Baek SJ, Kwak JM, Kim J, Kim SH. Oncologic outcomes in rectal cancer patients with a ≤1-cm distal resection margin. Int J Colorectal Dis. 2017 Mar;32(3):325-332.
  14. Imran J, Yao JJ, Madni T. Current Concepts on the Distal Margin of Resection of Rectal Cancer Tumors after Neoadjuvant Chemoradiation. Curr Colorectal Cancer Rep. 2017;13:10.
  15. Pangare TB, Waknis PP, Bawane SS, Patil MN, Wadhera S, Patowary PB. Effect of Formalin Fixation on Surgical Margins in Patients With Oral Squamous Cell Carcinoma. J Oral Maxillofac Surg. 2017 Jun;75(6):1293-1298
  16. Tran T, Sundaram CP, Bahler CD, Eble JN, Grignon DJ, Monn MF, Simper NB, Cheng L. Correcting the Shrinkage Effects of Formalin Fixation and Tissue Processing for Renal Tumors: toward Standardization Ho YM et al. 78 Ann Colorectal Res 2020;8(2) of Pathological Reporting of Tumor Size. J Cancer. 2015 Jul 2;6(8):759-66.
  17. Kwok SP, Lau WY, Leung KL, Liew CT, Li AK. Prospective analysis of the distal margin of clearance in anterior resec- tion for rectal carcinoma. Br J Surg. 1996;83:969-972.
  18. Battersby NJ, Juul T, Christensen P, et al. Predicting the Risk of BowelRelated Quality-of-Life Impairment After Restorative Resection for Rectal Cancer: A Multicenter CrossSectional Study. Dis Colon Rectum. 2016;59(4):270-280.
  19. Patel SA, Chen YH, Hornick JL, Catalano P, Nowak JA, Zukerberg LR, Bleday R, Shellito PC, Hong TS, Mamon HJ. Early-stage rectal cancer: clinical and pathologic prognostic markers of time to local recurrence and overall survival after resection. Dis Colon Rectum. 2014 Apr;57(4):449-59.
  20. Zeng WG, Liu MJ, Zhou ZX, Wang ZJ. A Distal Resection Margin of ≤1mm and Rectal Cancer Recurrence After Sphincter-Preserving Surgery: The Role of a Positive Distal Margin in Rectal Cancer Surgery. Dis Colon Rectum. 2017 Nov;60(11):1175-83.
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