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Sharifi Ardani, Parisa, Foroughinia, Farzaneh, Dianatpour, Mehdi, Jamhiri, Iman. (1399). Genotype and allele frequencies of two Vitamin-D receptor gene polymorphisms (ApaI and BsmI) in patients undergoing elective percutaneous coronary intervention in Iranian population. سامانه مدیریت نشریات علمی, 6(2), 105-112. doi: 10.30476/tips.2020.86329.1053
Parisa Sharifi Ardani; Farzaneh Foroughinia; Mehdi Dianatpour; Iman Jamhiri. "Genotype and allele frequencies of two Vitamin-D receptor gene polymorphisms (ApaI and BsmI) in patients undergoing elective percutaneous coronary intervention in Iranian population". سامانه مدیریت نشریات علمی, 6, 2, 1399, 105-112. doi: 10.30476/tips.2020.86329.1053
Sharifi Ardani, Parisa, Foroughinia, Farzaneh, Dianatpour, Mehdi, Jamhiri, Iman. (1399). 'Genotype and allele frequencies of two Vitamin-D receptor gene polymorphisms (ApaI and BsmI) in patients undergoing elective percutaneous coronary intervention in Iranian population', سامانه مدیریت نشریات علمی, 6(2), pp. 105-112. doi: 10.30476/tips.2020.86329.1053
Sharifi Ardani, Parisa, Foroughinia, Farzaneh, Dianatpour, Mehdi, Jamhiri, Iman. Genotype and allele frequencies of two Vitamin-D receptor gene polymorphisms (ApaI and BsmI) in patients undergoing elective percutaneous coronary intervention in Iranian population. سامانه مدیریت نشریات علمی, 1399; 6(2): 105-112. doi: 10.30476/tips.2020.86329.1053

Genotype and allele frequencies of two Vitamin-D receptor gene polymorphisms (ApaI and BsmI) in patients undergoing elective percutaneous coronary intervention in Iranian population

Trends in Pharmaceutical Sciences
مقاله 6، دوره 6، شماره 2، شهریور 2020، صفحه 105-112    اصل مقاله (423.83 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2020.86329.1053
نویسندگان
Parisa Sharifi Ardani1؛ Farzaneh Foroughinia* 2؛ Mehdi Dianatpour3، 4؛ Iman Jamhiri3
1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Science, Shiraz, Iran.
3Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: CAD is a major cause of death in worldwide. Both vitamin D (vit D) and Vitamin-D receptor (VDR) gene polymorphisms have been reported to be associated with Coronary artery disease (CAD). Because of high prevalence of vit D deficiency and mortality caused by cardiovascular diseases in our country, Iran, in this study we aimed to determine the frequency of two known VDR gene polymorphisms (BsmI and ApaI) in patients undergoing Percutaneous Coronary Intervention (PCI) in Iranian populations.
Methods: Blood samples were collected from 150 patients performing elective PCI (102 males and 48 females). VDR genotypes were determined by RFLP method. Serum vit D levels were measured using HPLC method and patients were divided into three groups as follows: subjects with a total vit D concentration 30 ng/ml> were described as normal, 20-30 ng/ml as insufficient and < 20 ng/ml as deficient.
Results: Among 150 samples analyzed for ApaI and BsmI polymorphisms the following genotypic frequency was observed: AA 44.67%, AC 44.67%, and CC 10.66% for ApaI and GG 47.33%, GA 37.33%, AA 15.34% for BsmI
Conclusions: Levels of active vitamin D could be influenced by both environmental and genetic factors. Our results also revealed that VDR gene polymorphisms (ApaI and BsmI) may vary across different ethnic groups in CAD patients.
کلیدواژه‌ها
vitamin D receptor؛ gene polymorphism؛ Coronary Intervention, Percutaneous؛ Iranian population
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