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Abdollahi, H, Shiri, I, Bevelacqua, J J, Jafarzadeh, A, Rahmim, A, Zaidi, H, Mortazavi, S A R, Mortazavi, S M J. (1399). Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients. سامانه مدیریت نشریات علمی, 10(4), 387-394. doi: 10.31661/jbpe.v0i0.2006-1125
H Abdollahi; I Shiri; J J Bevelacqua; A Jafarzadeh; A Rahmim; H Zaidi; S A R Mortazavi; S M J Mortazavi. "Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients". سامانه مدیریت نشریات علمی, 10, 4, 1399, 387-394. doi: 10.31661/jbpe.v0i0.2006-1125
Abdollahi, H, Shiri, I, Bevelacqua, J J, Jafarzadeh, A, Rahmim, A, Zaidi, H, Mortazavi, S A R, Mortazavi, S M J. (1399). 'Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients', سامانه مدیریت نشریات علمی, 10(4), pp. 387-394. doi: 10.31661/jbpe.v0i0.2006-1125
Abdollahi, H, Shiri, I, Bevelacqua, J J, Jafarzadeh, A, Rahmim, A, Zaidi, H, Mortazavi, S A R, Mortazavi, S M J. Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients. سامانه مدیریت نشریات علمی, 1399; 10(4): 387-394. doi: 10.31661/jbpe.v0i0.2006-1125

Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients

Journal of Biomedical Physics and Engineering
مقاله 1، دوره 10، شماره 4، مهر و آبان 2020، صفحه 387-394    اصل مقاله (625.75 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2006-1125
نویسندگان
H Abdollahi1؛ I Shiri2؛ J J Bevelacqua3؛ A Jafarzadeh4؛ A Rahmim5، 6؛ H Zaidi2، 7، 8، 9؛ S A R Mortazavi10؛ S M J Mortazavi* 11
1PhD, Department of Radiologic Sciences and Medical Physics, Faculty of Allied Medicine, Kerman University of Medical Science, Kerman, Iran
2PhD, Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211 Geneva 4, Switzerland
3PhD, Bevelacqua Resources, Richland, Washington, United States
4PhD, Department of Immunology, School of Medicine, Kerman University of Medical Science, Kerman, Iran
5PhD, Departments of Radiology and Physics, University of British Columbia, Vancouver BC, Canada
6PhD, Department of Integrative Oncology, BC Cancer Research Centre, Vancouver BC, Canada
7PhD, Geneva University Neurocenter, Geneva University, Geneva, Switzerland
8PhD, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
9PhD, Department of Nuclear Medicine, University of Southern Denmark, Odense, Denmark
10MD, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
11PhD, Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Physicians and scientists around the world are aggressively attempting to develop effective treatment strategies. The treatment goal is to reduce the fatality rate in 15% to 20% of individuals infected with SARS-CoV-2 who develop severe inflammatory conditions that can lead to pneumonia, and acute respiratory distress syndrome. These conditions are major causes of death in these patients. Convalescent plasma (CP) collected from patients recovered from the novel corona virus disease (COVID-19) has been considered as an effective treatment method for COVID-19. Moreover, low-dose radiation therapy (LDRT) for COVID-19 pneumonia was historically used to treat pneumonia during the first half of the 20th century. The concept of LDRT for COVID-19 pneumonia was first introduced in March 2020. Later scientists from Canada, Spain, United States, Germany and France also confirmed the potential efficacy of LDRT for treatment of COVID-19 pneumonia. The rationale behind introducing LDRT as an effective treatment method for pneumonia in COVID-19 patients is not only due to its anti-inflammatory effect, but also in optimization of the activity of the immune system. Moreover, LDRT, unlike other treatment methods such as antiviral drugs, does not have the key disadvantage of exerting a significant selective pressure on the SARS-CoV-2 virus and hence does not lead to evolution of the virus through mutations. Given these considerations, we believe that a hybrid treatment including both CP and LDRT can trigger synergistic responses that will help healthcare providers in mitigating today’s COVID-19 pandemic.
کلیدواژه‌ها
Low Dose Radiation؛ Radiotherapy؛ COVID-19؛ Convalescent Plasma؛ Anti-Inflammatory Responses؛ Immune System؛ Selective Pressure؛ Mutations
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