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Effects of Calendula Officinalis and Hypericum Perforatum on Antioxidant, Anti-Inflammatory and Histopathology Indices of Induced Periodontitis in Male Rats | ||
| Journal of Dentistry | ||
| مقاله 8، دوره 21، شماره 4 - شماره پیاپی 69، اسفند 2020، صفحه 314-321 اصل مقاله (477.58 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2020.83660.1056 | ||
| نویسندگان | ||
| Nader Tanideh1؛ Vajihe Ghafari2؛ Reyhaneh Ebrahimi3؛ Raha Habibagahi* 4؛ Omid Koohi-Hosseinabadi5؛ Aida Iraji6 | ||
| 1Stem Cells Technology Research Center and Dept. of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Students Research Committee, School of Dentistry, International Branch, Shiraz, University of Medical Sciences, Shiraz, Iran. | ||
| 3Dept. of Periodontology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 4Dept. of Biomaterials, Orthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 5Laboratory Animal Centre, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 6Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Statement of the Problem: Periodontitis is one of the most common bacterial infections of the oral cavity. It is important to find adjunctive methods to chemical treatment of periodontitis with less complications and proven therapeutic properties. Purpose: The aim of this study was to compare the effects of Calendula officinalis and Hypericum perforatum on antioxidant, antiinflammatory and histopathologic indices of induced periodontitis in male rats. Materials and Method: In this experimental animal study forty adult male Sprague-Dawley rats were randomly divided into 4 groups (n=10) and then experimental periodontitis was induced by 3-0 nylon non-absorbable ligature. Each group was treated for 10 days as follows: 1) H. perforatum hydroalcoholic extract, 1000 mg/kg/daily, orally; 2) C. officinalis hydroalcoholic extract, 1000 mg/kg/daily, orally; 3) a mix of the two plants, 1000 mg/kg/daily, orally; 4) normal saline solution. At the end of study, blood sample were obtained via cardiocentesis and the rats were euthanized and their maxillae were removed. The samples were analyzed for histopathological scores, total antioxidant capacity and IL-1β were measured. Results: Mixed hydroalchoholic extract of H. perforatum and C. officinalis decreased IL-1β (4.3020±0.63), and increased the antioxidant parameter in comparison to the control group (3.1192±0.43) (p < 0.001). There were significant histopathological differences between the treatment groups and the control group. Conclusion: Mixed hydroalchoholic extract of H. perforatum and C. officinalis might be considered as an adjunctive treatment for periodontitis. | ||
| کلیدواژه‌ها | ||
| Calendula officinalis؛ Hypericum perforatum؛ Periodontitis؛ Rats | ||
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