پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,111 |
| تعداد مقالات | 10,169 |
| تعداد مشاهده مقاله | 40,451,066 |
| تعداد دریافت فایل اصل مقاله | 8,650,959 |
Effects of Calendula Officinalis and Hypericum Perforatum on Antioxidant, Anti-Inflammatory and Histopathology Indices of Induced Periodontitis in Male Rats | ||
| Journal of Dentistry | ||
| مقاله 8، دوره 21، شماره 4 - شماره پیاپی 69، اسفند 2020، صفحه 314-321 اصل مقاله (477.58 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2020.83660.1056 | ||
| نویسندگان | ||
| Nader Tanideh1؛ Vajihe Ghafari2؛ Reyhaneh Ebrahimi3؛ Raha Habibagahi* 4؛ Omid Koohi-Hosseinabadi5؛ Aida Iraji6 | ||
| 1Stem Cells Technology Research Center and Dept. of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Students Research Committee, School of Dentistry, International Branch, Shiraz, University of Medical Sciences, Shiraz, Iran. | ||
| 3Dept. of Periodontology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 4Dept. of Biomaterials, Orthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 5Laboratory Animal Centre, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 6Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Statement of the Problem: Periodontitis is one of the most common bacterial infections of the oral cavity. It is important to find adjunctive methods to chemical treatment of periodontitis with less complications and proven therapeutic properties. Purpose: The aim of this study was to compare the effects of Calendula officinalis and Hypericum perforatum on antioxidant, antiinflammatory and histopathologic indices of induced periodontitis in male rats. Materials and Method: In this experimental animal study forty adult male Sprague-Dawley rats were randomly divided into 4 groups (n=10) and then experimental periodontitis was induced by 3-0 nylon non-absorbable ligature. Each group was treated for 10 days as follows: 1) H. perforatum hydroalcoholic extract, 1000 mg/kg/daily, orally; 2) C. officinalis hydroalcoholic extract, 1000 mg/kg/daily, orally; 3) a mix of the two plants, 1000 mg/kg/daily, orally; 4) normal saline solution. At the end of study, blood sample were obtained via cardiocentesis and the rats were euthanized and their maxillae were removed. The samples were analyzed for histopathological scores, total antioxidant capacity and IL-1β were measured. Results: Mixed hydroalchoholic extract of H. perforatum and C. officinalis decreased IL-1β (4.3020±0.63), and increased the antioxidant parameter in comparison to the control group (3.1192±0.43) (p < 0.001). There were significant histopathological differences between the treatment groups and the control group. Conclusion: Mixed hydroalchoholic extract of H. perforatum and C. officinalis might be considered as an adjunctive treatment for periodontitis. | ||
| کلیدواژه‌ها | ||
| Calendula officinalis؛ Hypericum perforatum؛ Periodontitis؛ Rats | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
[1] Kumar P, Ansari SH, Javed A. Herbal Remedies for the Treatment of Periodontal Disease- A Patent Review. Recent Patents on Drug Delivery & Formulation. 2009; 3: 221-228.
[2] Aithal G, Nayak U, Mehta C, Aithal GC, Nayak UY, Mehta C, et al. localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: Development and computational simulations. Molecules. 2018; 23: 1363.
[3] Lima MdR, Lopes AP, Martins C, Brito GAC, Carnerio VC, Goes P. The effect of Calendula officinalis on oxidative stress and bone loss in experimental periodontitis. Frontiers in physiology. 2017; 8: 440.
[4] Garcia VG, Júnior ECG, Ervolino E, Nagata MJH, Almeida JM, Theodoro LH. aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine. Photodiagnosis and photodynamic therapy. 2018; 22: 70-78.
[5] Hadfield RA, Vlahovic TC, Khan MT. The use of marigold therapy for podiatric skin conditions. Foot Ankle J. 2008; 1: 1-8.
[6] Preethi KC, Siveen KS, Kuttan R, Kuttan G. Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers. Asian Pac J Cancer Prev. 2010; 11: 1773–1779.
[7] Preethi KC, Kuttan G, Kuttan R. Antioxidant Potential of an Extract of Calendula officinalis. Flowers in vitro, and in vivo. Pharm biol. 2006; 44: 691–697.
[8] Meenatchisundaram S, Parameswari G, Subbraj T, Suganya T, Michael A. Note on pharmacological activities of Calendula officinalis L. Ethnobot Leaflets. 2009; 13: 51-54.
[9] Preethi KC, Kuttan G, Kuttan R. Anti-inflammatory activity of flower extract of Calendula officinalis Linn and its possible mechanism of action. Indian J Exp Biol. 2009; 47: 113–120.
[10] Tanideh N, Namazi F, Andisheh Tadbir A, Ebrahimi H, Koohi-Hosseinabadi O. Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters. Int J Oral Maxillofac Surg. 2014; 43: 1286-1292.
[11] Alexandre JTM, Sousa LHT, Lisboa MRP, Furlaneto FAC, Val DRD, Marques M, et al. Anti-inflammatory and antiresorptive effects of Calendula officinalis on inflammatory bone loss in rats. Clinical oral investigations. 2018; 22: 2175-2185.
[12] Galeotti N. Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions. Journal of ethnopharmacology. 2017; 200: 136-146.
[13] Abd El Motteleb DM, Abd El Aleem DI. Renoprotective effect of Hypericum perforatum against diabetic nephropathy in rats: Insights in the underlying mechanisms. Clinical and Experimental Pharmacology and Physiology. 2017; 44: 509-521.
[14] Tanideh N, Tavakoli P, Saghiri MA, Godoyd FG, Amanat D, Andisheh-Tadbir A. Healing acceleration in hamsters of oral mucositis induced by 5-fluorouracil with topical Calendula officinalis. Oral Surg Oral Med Oral Pathol Oral Radio. 2013; 115: 332-338.
[15] Tanideh N, Afaridi E, Mehrabani D, Azarpira N, Hosseinzadeh M, Amini M, et al. The healing effect of berberis vulgaris in acetic acid-induced ulcerative colitis in rat. Middle East J Sci Res. 2014; 21: 1288-1294.
[16] Lima V, Bezerra MM, Alencar VBM, Vidal FD, Rocha FA, Brito GAC, Ribeiro RA. Effects of chlorpromazine on alveolar bone loss in experimental periodontal disease in rats. Eur J Oral Sci. 2000; 108: 123-129.
[17] Menezes AM, Rocha FA, Chaves HV, Carvalho CB, Ribeiro RA, Brito GA. Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. J Periodontol. 2005; 76: 1901-1909.
[18] Koohi-Hosseinabadi O, Ranjbar Z, Sepehrimanesh M, AndisheTadbir A, Poorbaghi SL, Bahranifard H, et al. Biochemical, hematological, and pathological related healing effects of Elaeagnus angustifolia hydroalcoholic extract in 5-fluorouracil-induced oral mucositis in male golden hamster. Environmental Science and Pollution Research. 2017; 24: 24447-24453.
[19] Iraji A, Firuzi O, Khoshneviszadeh M, Nadri H, Edraki N, Miri R. Synthesis and structure-activity relationship study of multi-target triazine derivatives as innovative candidates for treatment of Alzheimer's disease. Bioorganic Chemistry. 2018; 77: 223-235.
[20] Dalcico R, de*Menezes AM, Deocleciano OB, Oriá RB, Vale ML, Ribeiro RA, Brito GADC. Protective mechanisms of simvastatin in experimental periodontal disease. J Periodontol. 2013; 84: 1145–1157.
[21] Tanideh N, Bahrani M, Khoshnood-Mansoorkhani MJ, Mehrabani D, Firoozi D, Koohi-Hosseinabadi O, et al. Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats. Ann Colorectal Res. 2016; 4: e42856.
[22] Oh H, Hirano J, Takai H, Ogata Y. Effects of initial periodontal therapy on interleukin-1ß level in gingival crevicular fluid and clinical periodontal parameters. J Oral Sci. 2015; 57: 67-71.
[23] Saini P, Shibani NA, Sun J, Zhang W, Song F, Gregson KS, Winds LJ. Effects of Calendula officinalis on human gingival fibroblasts. Homeopathy. 2012; 101: 92–98.
[24] Preethi KC, Kuttan R. Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns. J Clin Biochem Nutr. 2008; 43: 58-64.
[25] Ibrahim NA, Elwakkad AS, Khedre ME, Mourad HH, Sibaii H. Amelioration of trichl oroethylene- induced hepatic inflammatory response and oxidative stress by calendula officinalis in rats. International Journal of Academic Research. 2014; 6: 5.
[26] Kasote DM, Jayaprakasha GK, Patil BS. Leaf disc assays for rapid measurement of antioxidant activity. Scientific Reports. 2019; 9: 1884.
[27] De*Almeida LF, Souza SE, Sampaio AA, Cavalcanti YM, da*Silva WJ, Del*Bel Cur AA, et al. Effect of collagen matrix saturation on the surface free energy of dentin using different agents. J Contemp Dent Pract. 2015; 16: 531–536.
[28] Heijnen C G, Haenen GR, Oostveen RM, Stalpers EM, Bast A. Protection of flavonoids against lipid peroxidation: the structure activity relationship revisited. Free Radic Res. 2002; 36: 575–581.
[29] Jurikova T, Skrovankova S, Mlcek J, Balla S, Snopek L. Bioactive compounds, antioxidant activity, and biological effects of european cranberry (vaccinium oxycoccos). Molecules. 2019; 24: 24.
[30] Verma IM. Nuclear factor (NF)-kappaB proteins: therapeutic targets. Ann Rheum Dis. 2004; 63: 2.
[31] Damlar I, Arpag OF, Tatli U, Altan A. Effect of hypericum perforatum on the healing of xenografts: a histomorphometric study in rabbits. British Journal of Oral and Maxillofacial Surgery. 2017; 55: 383-387.
[32] Reid P, Holen I. Pathophysiological roles of osteoprotegerin (OPG). Eur J Cell Biol 2009; 88: 1–17.
[33] Öztürk N, Korkmaz S, Öztürk Y. Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts. Journal of Ethnopharmacology Journal of Ethnopharmacology. 2007; 111: 33-39. | ||
|
آمار تعداد مشاهده مقاله: 2,743 تعداد دریافت فایل اصل مقاله: 2,136 |
||
