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Bazrafshan, Ameneh, Khatamsaz, Saeed, Sani, Farnaz, Dehghan, Maryam. (1399). The relationships between KCNQ1 promoter mutation and some cardiac disease risk factors with cardiac arrhythmia in the Bushehr population. سامانه مدیریت نشریات علمی, 5(1), -. doi: 10.30476/jamsat.2020.46602
Ameneh Bazrafshan; Saeed Khatamsaz; Farnaz Sani; Maryam Dehghan. "The relationships between KCNQ1 promoter mutation and some cardiac disease risk factors with cardiac arrhythmia in the Bushehr population". سامانه مدیریت نشریات علمی, 5, 1, 1399, -. doi: 10.30476/jamsat.2020.46602
Bazrafshan, Ameneh, Khatamsaz, Saeed, Sani, Farnaz, Dehghan, Maryam. (1399). 'The relationships between KCNQ1 promoter mutation and some cardiac disease risk factors with cardiac arrhythmia in the Bushehr population', سامانه مدیریت نشریات علمی, 5(1), pp. -. doi: 10.30476/jamsat.2020.46602
Bazrafshan, Ameneh, Khatamsaz, Saeed, Sani, Farnaz, Dehghan, Maryam. The relationships between KCNQ1 promoter mutation and some cardiac disease risk factors with cardiac arrhythmia in the Bushehr population. سامانه مدیریت نشریات علمی, 1399; 5(1): -. doi: 10.30476/jamsat.2020.46602

The relationships between KCNQ1 promoter mutation and some cardiac disease risk factors with cardiac arrhythmia in the Bushehr population

Journal of Advanced Medical Sciences and Applied Technologies
مقاله 1، دوره 5، شماره 1، آبان 2020    اصل مقاله (457.47 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/jamsat.2020.46602
نویسندگان
Ameneh Bazrafshan1؛ Saeed Khatamsaz2؛ Farnaz Sani3؛ Maryam Dehghan* 2
1Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Biology, Islamic Azad University, Kazerun Branch, Kazerun, Iran
3Hematology and cell therapy department, Faculty of medical sciences, Tarbiat Modares university, Tehran,Iran
چکیده
Abstract
Objective:Many studies report that mutation in genes which encode the cardiac delayed rectifier potassium channel, such as KCNQ1, contributes to the long QT interval syndrome followed by cardiac arrhythmia.Goal of this case-control study is to explore the potential association between KCNQ1 gene promoter polymorphism and clinical Characteristics with cardiac arrhythmia in Bushehr population.
Methods:Clinical data, previous medical history, and blood samples were collected from 30 admitted patients in Bushehr hospitals with cardiac arrhythmia and matched healthy individuals as controls. The genetic variation of the promoter region of KCNQ1 was carried out by using single-strand conformational polymorphism (SSCP) analysis.
Results: NO mutation or polymorphism was identified in the promoter region of the KCNQ1 gene, but, the incidence rate of some cardiac disease risk factors, including diabetes mellitus, cigarette smoking, gender and age were significantly higher in the patients with cardiac arrhythmia.
Conclusions: The lack of mutation even in patients with a positive family history of cardiac arrhythmia revealed that mutation in the KCNQ1 gene might be not responsible for cardiac arrhythmia in the patients. But some clinical data, including diabetic mellitus, smoking habits, age and gender were the significant risk factors in patients with cardiac arrhythmia.
کلیدواژه‌ها
KCNQ1؛ polymorphism؛ cardiac arrhythmia؛ cardiac disease risk factors
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