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Zaman, M U, Fatima, N, Mehdi, S U, Sami, M, Khan, Kh, Khan, G. (1398). Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan. سامانه مدیریت نشریات علمی, 9(4), 409-416. doi: 10.31661/jbpe.v0i0.792
M U Zaman; N Fatima; S U Mehdi; M Sami; Kh Khan; G Khan. "Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan". سامانه مدیریت نشریات علمی, 9, 4, 1398, 409-416. doi: 10.31661/jbpe.v0i0.792
Zaman, M U, Fatima, N, Mehdi, S U, Sami, M, Khan, Kh, Khan, G. (1398). 'Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan', سامانه مدیریت نشریات علمی, 9(4), pp. 409-416. doi: 10.31661/jbpe.v0i0.792
Zaman, M U, Fatima, N, Mehdi, S U, Sami, M, Khan, Kh, Khan, G. Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan. سامانه مدیریت نشریات علمی, 1398; 9(4): 409-416. doi: 10.31661/jbpe.v0i0.792

Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan

Journal of Biomedical Physics and Engineering
مقاله 3، دوره 9، شماره 4، آبان 2019، صفحه 409-416    اصل مقاله (642.77 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.792
نویسندگان
M U Zaman* 1؛ N Fatima1؛ S U Mehdi1؛ M Sami2؛ Kh Khan1؛ G Khan1
1PET/CT Imaging Services, Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan
2Allmed Solution, Karachi, Pakistan
چکیده
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the first year (December 2015-November 2016) after commissioning.
Material and Methods: BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron (7.5 MeV proton beam, positive ion with current < 5µA) to produce [18F]F-, an automated card-based radiochemistry module to produce 18FDG and automated QC module to perform tests upon each batch of 18FDG. Data were collected for yields of [18F]F-, 18FDG, QC and radiation safety parameters.
Results: Total 545 runs in 167 days (3±01 runs/day) were made. Average yield with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [18F]F- and 18FDG, respectively. Total 29 runs had chemistry or QC failures and were discarded. Remaining 516 batches were used to perform imaging upon 1370 patients (8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits.
Conclusion: BG-75 Generator provides safe, dependable and sustainable supply of 18F-Fluoride for 18FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in cyclotron suite and personal dosimetry were also found within safe limits. Its Dose-on-Demand workflow offers a new concept of Personalized Dose Preparation which is currently not possible with a conventional cyclotron.
کلیدواژه‌ها
Cyclotron؛ Positron Emission Tomography Computed Tomography؛ Fluorodeoxyglucose 18F
مراجع
  1. Avril NE, Weber WA. Monitoring response to treatment in patients utilizing PET. Radiol Clin North Am. 2005;43:189-204. PubMed PMID: 15693656.
  2. Uz Zaman M, Fatima N, Sajjad Z, Zaman U, Tahseen R, Zaman A. 18FDG synthesis and supply: a journey from existing centralized to future decentralized models. Asian Pac J Cancer Prev. 2014;15:10057-9. PubMed PMID: 25556425.
  3. Hamacher K, Coenen HH, Stöcklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1986;27:235-8.
  4. United States Pharmacopeial C. The United States pharmacopeia. the national formulary. 36th revision 31st ed. Rockville: United States Pharmacopeial Convention; 2013.
  5. Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328-54. doi: 10.1007/s00259-014-2961-x. PubMed PMID: 25452219; PubMed Central PMCID: PMC4315529.
  6. Goethals PE, Zimmermann RG. Cyclotrons used in nuclear medicine world market report & directory. 2015th ed; 2015.
  7. Radioisotopes I, No RS [Internet]. Cyclotron Produced Radionuclides: Guidance on Facility Design and Production of [18F] Fluorodeoxyglucose (FDG). [cited 2017 June 12]. Available from: http://www-pub.iaea.org/mtcd/publications/pdf/pub1515_web.pdf
  8. Awasthi V, Watson J, Gali H, Matlock G, McFarland A, Bailey J, et al. A “dose on demand” Biomarker Generator for automated production of [(18)F]F(-) and [(18)F]FDG. Appl Radiat Isot. 2014;89:167-75. doi: 10.1016/j.apradiso.2014.02.015. PubMed PMID: 24650573.
  9. Gaspar L, Reich M, Kassai Z, Macasek F, Rodrigo L, Kruzliak P, et al. Long-term quality assurance of [(18)F]-fluorodeoxyglucose (FDG) manufacturing. Am J Nucl Med Mol Imaging. 2016;6:154-65. PubMed PMID: 27508102; PubMed Central PMCID: PMC4965520.
  10. Zargan S, Ghafarian P, Monfared AS, Sharafi A, Bakhshayeshkaram M, Ay M. Evaluation of radiation exposure to staff and environment dose from [18F]-FDG in PET/CT and cyclotron center using thermoluminescent dosimetry. Journal of biomedical physics & engineering. 2017;7:1.
  11. Schwarz SW, Dick D, VanBrocklin HF, Hoffman JM. Regulatory Requirements for PET Drug Production. J Nucl Med. 2014;55:1132-7. doi: 10.2967/jnumed.113.132472. PubMed PMID: 24914057.
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