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Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan | ||
Journal of Biomedical Physics and Engineering | ||
مقاله 3، دوره 9، شماره 4، آبان 2019، صفحه 409-416 اصل مقاله (642.77 K) | ||
نوع مقاله: Original Research | ||
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.792 | ||
نویسندگان | ||
M U Zaman* 1؛ N Fatima1؛ S U Mehdi1؛ M Sami2؛ Kh Khan1؛ G Khan1 | ||
1PET/CT Imaging Services, Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan | ||
2Allmed Solution, Karachi, Pakistan | ||
چکیده | ||
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the first year (December 2015-November 2016) after commissioning. Material and Methods: BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron (7.5 MeV proton beam, positive ion with current < 5µA) to produce [18F]F-, an automated card-based radiochemistry module to produce 18FDG and automated QC module to perform tests upon each batch of 18FDG. Data were collected for yields of [18F]F-, 18FDG, QC and radiation safety parameters. Results: Total 545 runs in 167 days (3±01 runs/day) were made. Average yield with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [18F]F- and 18FDG, respectively. Total 29 runs had chemistry or QC failures and were discarded. Remaining 516 batches were used to perform imaging upon 1370 patients (8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits. Conclusion: BG-75 Generator provides safe, dependable and sustainable supply of 18F-Fluoride for 18FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in cyclotron suite and personal dosimetry were also found within safe limits. Its Dose-on-Demand workflow offers a new concept of Personalized Dose Preparation which is currently not possible with a conventional cyclotron. | ||
کلیدواژهها | ||
Cyclotron؛ Positron Emission Tomography Computed Tomography؛ Fluorodeoxyglucose 18F | ||
مراجع | ||
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