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Rahimi-Moghaddam, F, Sattarahmady, N, Azarpira, N. (1398). Gold-Curcumin Nanostructure in Photo-thermal Therapy on Breast Cancer Cell Line: 650 and 808 nm Diode Lasers as Light Sources. سامانه مدیریت نشریات علمی, 9(4), 473-482. doi: 10.31661/jbpe.v0i0.906
F Rahimi-Moghaddam; N Sattarahmady; N Azarpira. "Gold-Curcumin Nanostructure in Photo-thermal Therapy on Breast Cancer Cell Line: 650 and 808 nm Diode Lasers as Light Sources". سامانه مدیریت نشریات علمی, 9, 4, 1398, 473-482. doi: 10.31661/jbpe.v0i0.906
Rahimi-Moghaddam, F, Sattarahmady, N, Azarpira, N. (1398). 'Gold-Curcumin Nanostructure in Photo-thermal Therapy on Breast Cancer Cell Line: 650 and 808 nm Diode Lasers as Light Sources', سامانه مدیریت نشریات علمی, 9(4), pp. 473-482. doi: 10.31661/jbpe.v0i0.906
Rahimi-Moghaddam, F, Sattarahmady, N, Azarpira, N. Gold-Curcumin Nanostructure in Photo-thermal Therapy on Breast Cancer Cell Line: 650 and 808 nm Diode Lasers as Light Sources. سامانه مدیریت نشریات علمی, 1398; 9(4): 473-482. doi: 10.31661/jbpe.v0i0.906

Gold-Curcumin Nanostructure in Photo-thermal Therapy on Breast Cancer Cell Line: 650 and 808 nm Diode Lasers as Light Sources

Journal of Biomedical Physics and Engineering
مقاله 11، دوره 9، شماره 4، مهر و آبان 2019، صفحه 473-482    اصل مقاله (646.26 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.906
نویسندگان
F Rahimi-Moghaddam1؛ N Sattarahmady* 1، 2؛ N Azarpira3
1Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Au nanoparticles (AuNPs) exhibit very unique physiochemical and optical properties, which now are extensively studied in a range of medical diagnostic and therapeutic applications. AuNPs can be used for cancer clinical treatment with minimal invasion. On the other hand, curcumin is a polyphenol derived from turmeric which is used for medical purposes due to its anti-cancer, anti-microbial, anti-oxidant and anti-inflammatory properties. Despite these potential properties of curcumin, its usage is limited in medicine due to low solubility in water. Conjugation of curcumin to AuNPs (Au-Cur nanostructure) can be increasing its solubility. Photo-thermal therapy (PTT) is a novel kind of cancer treatment which involves two major components: laser and photo-thermoconversion agents.
Materials and Methods: Here, diode lasers emitting 808 nm and 650 nm were utilized as light sources, and synthesized Au-Cur nanostructure was applied as a photo-thermo conversion agent. UV-vis absorbance spectroscopy and dynamic light scattering (DLS) were applied to study the maximum absorption of particles, size stability of the samples and their zeta potential. The synthesized Au-Cur nanostructure under irradiation of laser is used for PPT on 4T1 cells. The cytotoxicity activity of Au-Cur nanostructure and laser irradiation on 4T1 cells was evaluated by MTT assay.
Results: Synthesized Au-Cur nanostructure showed λmax at 540 nm and a mean hydrodynamic diameter of 25.8 nm. 4T1 cells were exposed to an 808 nm diode laser (1.5 W cm2, 10 min) in the presence of different concentrations of Au-Cur nanostructure. Next, 4T1 cells with Au-Vur nanostructure were exposed to diode laser beam (650 nm, 1.5 W cm2) for 10 min. The results revealed that Au-Cur nanostructure under laser irradiation of 808 nm more decreased cell viability of 4T1 cells compared to laser irradiation of 650 nm.
Conclusion: It was concluded that combining an 808-nm laser at a power density of 1.5W/cm2 with Au-Cur nanostructure has a destruction effect on 4T1 breast cancer cells in vitro experiments compared to laser irradiation of 650 nm.
کلیدواژه‌ها
Curcumin؛ Lasers؛ Semiconductor؛ Nanostructures
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