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Siri, Morvarid, Hosseini, Seyed Vahid, Dastghaib, Sanaz, Mokarram, Pooneh. (1398). Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer. سامانه مدیریت نشریات علمی, 8(1), 9-16. doi: 10.30476/acrr.2020.46538
Morvarid Siri; Seyed Vahid Hosseini; Sanaz Dastghaib; Pooneh Mokarram. "Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer". سامانه مدیریت نشریات علمی, 8, 1, 1398, 9-16. doi: 10.30476/acrr.2020.46538
Siri, Morvarid, Hosseini, Seyed Vahid, Dastghaib, Sanaz, Mokarram, Pooneh. (1398). 'Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer', سامانه مدیریت نشریات علمی, 8(1), pp. 9-16. doi: 10.30476/acrr.2020.46538
Siri, Morvarid, Hosseini, Seyed Vahid, Dastghaib, Sanaz, Mokarram, Pooneh. Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer. سامانه مدیریت نشریات علمی, 1398; 8(1): 9-16. doi: 10.30476/acrr.2020.46538

Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer

Iranian Journal of Colorectal Research
مقاله 2، دوره 8، شماره 1، خرداد 2020، صفحه 9-16    اصل مقاله (859.72 K)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2020.46538
نویسندگان
Morvarid Siri1؛ Seyed Vahid Hosseini2؛ Sanaz Dastghaib1؛ Pooneh Mokarram* 3
1Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran
2Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Autophagy Research center, Shiraz University of Medical Sciences, shiraz, Iran.
چکیده
Abstract:
1. Context
Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions.
2. Evidence Acquisition
There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors.
3. Results
Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions.
4. Conclusions
The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.
کلیدواژه‌ها
Endoplasmic reticulum؛ Stress؛ Cancer؛ UPR؛ Wnt
مراجع

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