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Mehnati, Parinaz, Ghorbanipoor, Maryam, Mohammadzadeh, Mohammad, Nasiri Motlagh, Behnam, Mesbahi, Asghar. (1400). Predicting the Risk of Radiation Pneumonitis and Pulmonary Function Changes after Breast Cancer Radiotherapy. سامانه مدیریت نشریات علمی, 11(4), 459-464. doi: 10.31661/jbpe.v0i0.1079
Parinaz Mehnati; Maryam Ghorbanipoor; Mohammad Mohammadzadeh; Behnam Nasiri Motlagh; Asghar Mesbahi. "Predicting the Risk of Radiation Pneumonitis and Pulmonary Function Changes after Breast Cancer Radiotherapy". سامانه مدیریت نشریات علمی, 11, 4, 1400, 459-464. doi: 10.31661/jbpe.v0i0.1079
Mehnati, Parinaz, Ghorbanipoor, Maryam, Mohammadzadeh, Mohammad, Nasiri Motlagh, Behnam, Mesbahi, Asghar. (1400). 'Predicting the Risk of Radiation Pneumonitis and Pulmonary Function Changes after Breast Cancer Radiotherapy', سامانه مدیریت نشریات علمی, 11(4), pp. 459-464. doi: 10.31661/jbpe.v0i0.1079
Mehnati, Parinaz, Ghorbanipoor, Maryam, Mohammadzadeh, Mohammad, Nasiri Motlagh, Behnam, Mesbahi, Asghar. Predicting the Risk of Radiation Pneumonitis and Pulmonary Function Changes after Breast Cancer Radiotherapy. سامانه مدیریت نشریات علمی, 1400; 11(4): 459-464. doi: 10.31661/jbpe.v0i0.1079

Predicting the Risk of Radiation Pneumonitis and Pulmonary Function Changes after Breast Cancer Radiotherapy

Journal of Biomedical Physics and Engineering
مقاله 6، دوره 11، شماره 4، آبان 2021، صفحه 459-464    اصل مقاله (532.82 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1079
نویسندگان
Parinaz Mehnati1؛ Maryam Ghorbanipoor* 2؛ Mohammad Mohammadzadeh3؛ Behnam Nasiri Motlagh3؛ Asghar Mesbahi4
1PhD, Immunology research center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2MSc, Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3MD, Department of Radiology, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
4PhD, Medical Radiation Sciences Research team, Department of Medical Physics, School of Medicine, Tabriz, Iran
چکیده
Background: Radiotherapy plays an important role in the treatment of breast cancer. In the process of radiotherapy, the underling lung tissue receives higher doses from treatment field, which led to incidence of radiation pneumonitis.
Objective: The present study aims to evaluate the predictive factors of radiation pneumonitis and related changes in pulmonary function after 3D-conformal radiotherapy of breast cancer.
Material and Methods: In prospective basis study, thirty-two patients with breast cancer who received radiotherapy after surgery, were followed up to 6 months. Respiratory symptoms, lung radiologic changes and pulmonary function were evaluated. Radiation pneumonitis (RP) was graded according to common terminology criteria for adverse events (CTCAE) version 3.0. Dose-volume parameters, which included percentage of lung volume receiving dose of d Gy (V5-V50) and mean lung dose (MLD), were evaluated for RP prediction. Pulmonary function evaluated by spirometry test and changes of FEV1 and FVC parameters.
Results: Eight patients developed RP. Among the dose-volume parameters, V10 was associated to RP incidence. When V10<40% and V10≥40% the incidences of RP were 5.26% and 61.54%, respectively. The FEV1 and FVC had a reduction 3 and 6 months after radiotherapy, while only FEV1 showed significant reduction. The FEV1 had more reduction in the patients who developed RP than patients without RP (15.25±3.81 vs. 9.2±0.93).
Conclusion: Pulmonary function parameters, especially FEV1, significantly decreased at 3 and 6 months after radiotherapy. Since most patients with breast cancer who developed RP did not show obvious clinical symptoms, so spirometry test is beneficial to identify patients with risk of radiation pneumonitis.
کلیدواژه‌ها
Breast Cancer؛ Radiation Pneumonitis؛ 3-D Conformal Radiotherapy؛ Spirometry؛ Lung
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