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Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. (1400). Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study. سامانه مدیریت نشریات علمی, 11(5), 629-640. doi: 10.31661/jbpe.v0i0.1131
Zahra Khodabakhshi; Nazanin Hosseinkhah; Hossein Ghadiri. "Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study". سامانه مدیریت نشریات علمی, 11, 5, 1400, 629-640. doi: 10.31661/jbpe.v0i0.1131
Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. (1400). 'Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study', سامانه مدیریت نشریات علمی, 11(5), pp. 629-640. doi: 10.31661/jbpe.v0i0.1131
Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study. سامانه مدیریت نشریات علمی, 1400; 11(5): 629-640. doi: 10.31661/jbpe.v0i0.1131

Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study

Journal of Biomedical Physics and Engineering
مقاله 9، دوره 11، شماره 5، دی 2021، صفحه 629-640    اصل مقاله (1.43 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1131
نویسندگان
Zahra Khodabakhshi1، 2؛ Nazanin Hosseinkhah3؛ Hossein Ghadiri* 4، 5
1MSc, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Science, Tehran, Iran
2MSc, Research Center for Molecular and Cellular Imaging (RCMCI), Tehran, Iran
3PhD, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
4PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Science, Tehran, Iran
5PhD, Research Center for Molecular and Cellular Imaging (RCMCI), Tehran, Iran
چکیده
Background: Microbubbles are widely used in diagnostic ultrasound applications as contrast agents. Recently, many studies have shown that microbubbles have good potential for the use in therapeutic applications such as drug and gene delivery and opening of blood- brain barrier locally and transiently. When microbubbles are located inside an elastic microvessel and activated by ultrasound, they oscillate and induce mechanical stresses on the vessel wall. However, the mechanical stresses have beneficial therapeutic effects, they may induce vessel damage if they are too high. Microstreaming-induced shear stress is one of the most important wall stresses.
Objective: The overall aim of this study is to simulate the interaction between confined bubble inside an elastic microvessel and ultrasound field and investigate the effective parameters on microstreaming-induced shear stress.
Material and Methods: In this Simulation study, we conducted a 2D finite element simulation to study confined microbubble dynamics, also we investigated both acoustical and bubble material parameters on microbubble oscillation and wall stress.
Results: Based on our results, for acoustic parameters in the range of therapeutic applications, the maximum shear stress was lower than 4 kPa. Shear stress was approximately independent from shell viscosity whereas it decreased by increasing the shell stiffness. Moreover, shear stress showed an increasing trend with acoustic pressure.
Conclusion: Beside the acoustical parameters, bubble properties have important effects on bubble behavior so that the softer and larger bubbles are more appropriate for therapeutic application as they can decrease the required frequency and acoustic pressure while inducing the same biological effects.
کلیدواژه‌ها
Ultrasound؛ Microbubbles؛ Shear Stress؛ Therapeutics؛ Blood-Brain-Barrier
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