LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات9,995
تعداد مشاهده مقاله26,322,857
تعداد دریافت فایل اصل مقاله7,271,282
Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. (1400). Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study. سامانه مدیریت نشریات علمی, 11(5), 629-640. doi: 10.31661/jbpe.v0i0.1131
Zahra Khodabakhshi; Nazanin Hosseinkhah; Hossein Ghadiri. "Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study". سامانه مدیریت نشریات علمی, 11, 5, 1400, 629-640. doi: 10.31661/jbpe.v0i0.1131
Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. (1400). 'Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study', سامانه مدیریت نشریات علمی, 11(5), pp. 629-640. doi: 10.31661/jbpe.v0i0.1131
Khodabakhshi, Zahra, Hosseinkhah, Nazanin, Ghadiri, Hossein. Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study. سامانه مدیریت نشریات علمی, 1400; 11(5): 629-640. doi: 10.31661/jbpe.v0i0.1131

Pulsating Microbubble in a Micro-vessel and Mechanical Effect on Vessel Wall: A Simulation Study

Journal of Biomedical Physics and Engineering
مقاله 9، دوره 11، شماره 5، آذر و دی 2021، صفحه 629-640    اصل مقاله (1.43 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1131
نویسندگان
Zahra Khodabakhshi1، 2؛ Nazanin Hosseinkhah3؛ Hossein Ghadiri* 4، 5
1MSc, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Science, Tehran, Iran
2MSc, Research Center for Molecular and Cellular Imaging (RCMCI), Tehran, Iran
3PhD, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
4PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Science, Tehran, Iran
5PhD, Research Center for Molecular and Cellular Imaging (RCMCI), Tehran, Iran
چکیده
Background: Microbubbles are widely used in diagnostic ultrasound applications as contrast agents. Recently, many studies have shown that microbubbles have good potential for the use in therapeutic applications such as drug and gene delivery and opening of blood- brain barrier locally and transiently. When microbubbles are located inside an elastic microvessel and activated by ultrasound, they oscillate and induce mechanical stresses on the vessel wall. However, the mechanical stresses have beneficial therapeutic effects, they may induce vessel damage if they are too high. Microstreaming-induced shear stress is one of the most important wall stresses.
Objective: The overall aim of this study is to simulate the interaction between confined bubble inside an elastic microvessel and ultrasound field and investigate the effective parameters on microstreaming-induced shear stress.
Material and Methods: In this Simulation study, we conducted a 2D finite element simulation to study confined microbubble dynamics, also we investigated both acoustical and bubble material parameters on microbubble oscillation and wall stress.
Results: Based on our results, for acoustic parameters in the range of therapeutic applications, the maximum shear stress was lower than 4 kPa. Shear stress was approximately independent from shell viscosity whereas it decreased by increasing the shell stiffness. Moreover, shear stress showed an increasing trend with acoustic pressure.
Conclusion: Beside the acoustical parameters, bubble properties have important effects on bubble behavior so that the softer and larger bubbles are more appropriate for therapeutic application as they can decrease the required frequency and acoustic pressure while inducing the same biological effects.
کلیدواژه‌ها
Ultrasound؛ Microbubbles؛ Shear Stress؛ Therapeutics؛ Blood-Brain-Barrier
سایر فایل های مرتبط با مقاله
مراجع
  1. Ferrara K, Pollard R, Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. 2007;9:415-47. doi: 10.1146/annurev.bioeng.8.061505.095852. PubMed PMID: 17651012.
  2. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R. Therapeutic applications of microbubbles. Eur J Radiol. 2002;42:160-8. PubMed PMID: 11976013.
  3. Kooiman K, Emmer M, Foppen-Harteveld M, van Wamel A, de Jong N. Increasing the endothelial layer permeability through ultrasound-activated microbubbles. IEEE Trans Biomed Eng. 2010;57:29-32. doi: 10.1109/TBME.2009.2030335. PubMed PMID: 19709954.
  4. Kooiman K, Foppen-Harteveld M, van der Steen AF, de Jong N. Sonoporation of endothelial cells by vibrating targeted microbubbles. J Control Release. 2011;154:35-41. doi: 10.1016/j.jconrel.2011.04.008. PubMed PMID: 21514333.
  5. Sonoda S, Tachibana K, Uchino E, Yamashita T, et al. Inhibition of melanoma by ultrasound-microbubble-aided drug delivery suggests membrane permeabilization. Cancer Biol Ther. 2007;6:1276-83. doi: 10.4161/cbt.6.8.4485. PubMed PMID: 17704642.
  6. Endoh M, Koibuchi N, Sato M, Morishita R, Kanzaki T, Murata Y, et al. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Mol Ther. 2002;5:501-8. doi: 10.1006/mthe.2002.0577. PubMed PMID: 11991740.
  7. Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology. 2001;220:640-6. doi: 10.1148/radiol.2202001804. PubMed PMID: 11526261.
  8. Gormley G, Wu J. Observation of acoustic streaming near Albunex® spheres. The Journal of the Acoustical Society of America. 1998;104:3115-8. doi: 10.1121/1.423903.
  9. Wu J. Theoretical study on shear stress generated by microstreaming surrounding contrast agents attached to living cells. Ultrasound Med Biol. 2002;28:125-9. doi: 10.1016/s0301-5629(01)00497-5. PubMed PMID: 11879959.
  10. Meijering BD, Juffermans LJ, van Wamel A, Henning RH, Zuhorn IS, Emmer M, et al. Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation. Circ Res. 2009;104:679-87. doi: 10.1161/CIRCRESAHA.108.183806. PubMed PMID: 19168443.
  11. Ando H, Feril LB, Jr., Kondo T, Tabuchi Y, Ogawa R, Zhao QL, et al. An echo-contrast agent, Levovist, lowers the ultrasound intensity required to induce apoptosis of human leukemia cells. Cancer Lett. 2006;242:37-45. doi: 10.1016/j.canlet.2005.10.032. PubMed PMID: 16377079.
  12. Sassaroli E, Hynynen K. Resonance frequency of microbubbles in small blood vessels: a numerical study. Phys Med Biol. 2005;50:5293-305. doi: 10.1088/0031-9155/50/22/006. PubMed PMID: 16264254.
  13. Qin S, Ferrara KW. Acoustic response of compliable microvessels containing ultrasound contrast agents. Phys Med Biol. 2006;51:5065-88. doi: 10.1088/0031-9155/51/20/001. PubMed PMID: 17019026. PubMed PMCID: PMC2847449.
  14. Martynov S, Stride E, Saffari N. The natural frequencies of microbubble oscillation in elastic vessels. J Acoust Soc Am. 2009;126:2963-72. doi: 10.1121/1.3243292. PubMed PMID: 20000909.
  15. Doinikov AA, Bouakaz A. Theoretical investigation of shear stress generated by a contrast microbubble on the cell membrane as a mechanism for sonoporation. J Acoust Soc Am. 2010;128:11-9. doi: 10.1121/1.3419775. PubMed PMID: 20649196.
  16. Wiedemair W, Tukovic Z, Jasak H, Poulikakos D, Kurtcuoglu V. On ultrasound-induced microbubble oscillation in a capillary blood vessel and its implications for the blood-brain barrier. Phys Med Biol. 2012;57:1019-45. doi: 10.1088/0031-9155/57/4/1019. PubMed PMID: 22298199.
  17. Hosseinkhah N, Hynynen K. A three-dimensional model of an ultrasound contrast agent gas bubble and its mechanical effects on microvessels. Phys Med Biol. 2012;57:785-808. doi: 10.1088/0031-9155/57/3/785. PubMed PMID: 22252221. PubMed PMCID: PMC3367455.
  18. Chen C, Gu Y, Tu J, Guo X, Zhang D. Microbubble oscillating in a microvessel filled with viscous fluid: A finite element modeling study. Ultrasonics. 2016;66:54-64. doi: 10.1016/j.ultras.2015.11.010. PubMed PMID: 26651263.
  19. Guo X, Cai C, Xu G, Yang Y, Tu J, et al. Interaction between cavitation microbubble and cell: A simulation of sonoporation using boundary element method (BEM). Ultrason Sonochem. 2017;39:863-71. doi: 10.1016/j.ultsonch.2017.06.016. PubMed PMID: 28733016.
  20. Hay TA, Ilinskii YA, Zabolotskaya EA, Hamilton MF. Model for the dynamics of a spherical bubble undergoing small shape oscillations between parallel soft elastic layers. J Acoust Soc Am. 2013;134:1454-62. doi: 10.1121/1.4812864. PubMed PMID: 23927185. PubMed PMCID: PMC3749046.
  21. Miao H, Gracewski SM, Dalecki D. Ultrasonic excitation of a bubble inside a deformable tube: implications for ultrasonically induced hemorrhage. J Acoust Soc Am. 2008;124:2374-84. doi: 10.1121/1.2967488. PubMed PMID: 19062875. PubMed PMCID: PMC2677346.
  22. Mobadersany N, Sarkar K. The dynamic of contrast agent and surrounding fluid in the vicinity of a wall for sonoporation. ArXiv Preprint ArXiv:180208652. 2018.
  23. Burton AC. Role of geometry, of size and shape, in the microcirculation. Fed Proc. 1966;25:1753-60. PubMed PMID: 5951414.
  24. De Jong N, Cornet R, Lancée Cd. Higher harmonics of vibrating gas-filled microspheres. Part one: simulations. Ultrasonics. 1994;32:447-53. doi: 10.1016/0041-624x(94)90064-7.
  25. Hasegawa H, Kanai H, Chubachi N, Koiwa Y. Non-invasive evaluation of Poisson’s ratio of arterial wall using ultrasound. Electronics letters. 1997;33:340-2. doi: 10.1049/el:19970219.
  26. Duck FA. Physical properties of tissues: a comprehensive reference book. United Kingdom: IPEM; 2013.
  27. Tu J, Swalwell JE, Giraud D, Cui W, Chen W, Matula TJ. Microbubble sizing and shell characterization using flow cytometry. IEEE Trans Ultrason Ferroelectr Freq Control. 2011;58:955-63. doi: 10.1109/TUFFC.2011.1896. PubMed PMID: 21622051. PubMed PMCID: PMC4495763.
  28. Helfield BL, Goertz DE. Nonlinear resonance behavior and linear shell estimates for Definity™ and MicroMarker™ assessed with acoustic microbubble spectroscopy. The Journal of the Acoustical Society of America. 2013;133:1158-68. doi: 10.1121/1.4774379.
  29. Hosseinkhah N, Chen H, Matula TJ, Burns PN, Hynynen K. Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study. J Acoust Soc Am. 2013;134:1875-85. doi: 10.1121/1.4817843. PubMed PMID: 23967921. PubMed PMCID: PMC3765296.
  30. Nyborg WL. Acoustic streaming near a boundary. The Journal of the Acoustical Society of America. 1958;30:329-39. doi: 10.1121/1.1909587.
  31. Miller MW. Cell size relations for sonolysis. Ultrasound Med Biol. 2004;30:1263-7. doi: 10.1016/j.ultrasmedbio.2004.07.005. PubMed PMID: 15582225.
  32. Vos HJ, Dollet B, Versluis M, De Jong N. Nonspherical shape oscillations of coated microbubbles in contact with a wall. Ultrasound Med Biol. 2011;37:935-48. doi: 10.1016/j.ultrasmedbio.2011.02.013. PubMed PMID: 21601137.
  33. Dijkink R, Ohl C-D. Measurement of cavitation induced wall shear stress. Applied Physics Letters. 2008;93:254107. doi: 10.1063/1.3046735.
  34. Faez T, Emmer M, Kooiman K, Versluis M, Van Der Steen A, De Jong N. 20 years of ultrasound contrast agent modeling. IEEE Trans Ultrason Ferroelectr Freq Control. 2013;60:7-20. doi: 10.1109/TUFFC.2013.2533. PubMed PMID: 23287909.
  35. Van Der Meer SM, Dollet B, Voormolen MM, Chin CT, Bouakaz A, De Jong N, et al. Microbubble spectroscopy of ultrasound contrast agents. J Acoust Soc Am. 2007;121:648-56. PubMed PMID: 17297818.
آمار
تعداد مشاهده مقاله: 1,465
تعداد دریافت فایل اصل مقاله: 806


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب