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Formulation and Evaluation of Delayed Release Enteric Coated Tablets of Tenatoprazole, by Optimizing the Plymers | ||
| Trends in Pharmaceutical Sciences | ||
| مقاله 3، دوره 6، شماره 1، خرداد 2020، صفحه 21-28 اصل مقاله (462.62 K) | ||
| نوع مقاله: Research(Original) Article | ||
| شناسه دیجیتال (DOI): 10.30476/tips.2020.85126.1041 | ||
| نویسندگان | ||
| Nikunja B Pati* ؛ Swapna Velivela؛ Vinyas Mayasa؛ Ravindra Babu Baggi | ||
| Dept. of Pharmaceutics, Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University (Pulla Reddy Institute of Pharmacy), Hyderabad, India. | ||
| چکیده | ||
| The present study was undertaken with an aim to formulate enteric coated tablets of Tenatoprazole (a novel proton pump inhibitor with an imidazopyridine ring) to improve bioavailability by avoiding degradation. Different core tablets were prepared using approved excipients by direct compression method and evaluated for different parameters like hardness, thickness, friability and disintegration time. Sub-coating was done for optimized formulation (F5) by using HPMC 5 cps with buildup of 3% w/w and finally enteric coating was done by using HPMCP, Eudragit L30 D55 and HPMC Acetate succinate (HPMCAS) with an average weight buildup of 5%, 8% and 10% w/w. all formulations were evaluated for different parameters like hardness, friability, thickness, disintegration time, drug content and dissolution studies and compared with marketed sample. Results indicated that, methacrylic acid polymers exhibited better dissolution rate than cellulose polymers. The optimized formulation was subjected to stability studies as per ICH guidelines for 3 months and was observed that no significant change was observed. | ||
| کلیدواژه‌ها | ||
| Sub-coating؛ enteric coating tablets؛ HPMCP؛ Eudragit L30 D55؛ HPMCAS؛ Stability studies | ||
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آمار تعداد مشاهده مقاله: 1,333 تعداد دریافت فایل اصل مقاله: 645 |
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