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Zarrinhaghighi, Amir, Dehshahri, Ali. (1398). An in Silico Approach to Find the Molecular Targets and Potential Candidates for SARS-CoV-2. سامانه مدیریت نشریات علمی, 6(1), 11-20. doi: 10.30476/tips.2020.86025.1045
Amir Zarrinhaghighi; Ali Dehshahri. "An in Silico Approach to Find the Molecular Targets and Potential Candidates for SARS-CoV-2". سامانه مدیریت نشریات علمی, 6, 1, 1398, 11-20. doi: 10.30476/tips.2020.86025.1045
Zarrinhaghighi, Amir, Dehshahri, Ali. (1398). 'An in Silico Approach to Find the Molecular Targets and Potential Candidates for SARS-CoV-2', سامانه مدیریت نشریات علمی, 6(1), pp. 11-20. doi: 10.30476/tips.2020.86025.1045
Zarrinhaghighi, Amir, Dehshahri, Ali. An in Silico Approach to Find the Molecular Targets and Potential Candidates for SARS-CoV-2. سامانه مدیریت نشریات علمی, 1398; 6(1): 11-20. doi: 10.30476/tips.2020.86025.1045

An in Silico Approach to Find the Molecular Targets and Potential Candidates for SARS-CoV-2

Trends in Pharmaceutical Sciences
مقاله 2، دوره 6، شماره 1، خرداد 2020، صفحه 11-20    اصل مقاله (669.02 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2020.86025.1045
نویسندگان
Amir Zarrinhaghighi1؛ Ali Dehshahri* 2، 3
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Pharmaceutical Sciences Research center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
The rapid spread of SARS-CoV-2 has led researchers to seek novel drugs as well as re-purposing the existing drugs to prevent control or treat COVID-19. An interesting approach is to focus on the molecular pathways which could act as a drug target in this disease. Since the molecular pathways associated with SARS-CoV-2 are still unclear, the SARS-CoV infected patients and the convalescent individuals were selected as the model for SARS-CoV-2 infection and an in silico study was designed to identify the potential pathways which could act as the target for drug molecules. In the next step, the drugs with the ability to target these pathways were selected and introduced as potential compounds for further investigations to finding a drug for COVID-19. The results revealed that lycorine and GW-5074 are two small molecules with the ability to target the selected pathways. Interestingly, these compounds had shown antiviral activity against a broad range of viruses, including SARS-CoV. The results obtained in this in silico study could be considered as a primary study for further investigations.
کلیدواژه‌ها
SARS-CoV-2؛ COVID-19؛ molecular pathways؛ drug candidate
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