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T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia | ||
| Iranian Journal of Immunology | ||
| مقاله 8، دوره 17، شماره 1، خرداد 2020، صفحه 87-93 اصل مقاله (505.53 K) | ||
| نوع مقاله: Short Paper | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2020.80297 | ||
| نویسندگان | ||
| Marina Nayeli Medina-Rosales1؛ Susana Godina-Gonzalez2؛ Mariana Haydee Garcia-Hernandez* 1 | ||
| 1Unidad de Investigación Biomédica de Zacatecas. Delegación Zacatecas, Instituto Mexicano del Seguro Social, IMSS, México | ||
| 2Facultad de Ciencias Qumicas, Universidad Autónoma de Zacatecas, UAZ, México | ||
| چکیده | ||
| Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Materials: We evaluated the percentages of regulatory T cells by flow cytometry. Soluble CTLA-4 (sCTLA-4) in plasma was evaluated by ELISA assay. Results: Increased percentages of CD4+CD25+ T cells, CD4+CD39+ T cells, CD4+Foxp3+ T cells, and CD4+CD25High T cells were observed in children with ALL in comparison to healthy controls. In addition, the ALL patients with >12 months of therapy showed increased CD4+CD39+ T cells compared to the ALL patients with ≤12 months and healthy controls. Similarly, the CD4+CD25+ T cells and CD4+Foxp3+ T cells increased according to maintenance therapy time. Conclusion: Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response. | ||
| کلیدواژه‌ها | ||
| Acute Lymphoblastic Leukemia؛ ALL؛ Chemoterapy؛ Pedriatic؛ T Regulatory Cells | ||
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آمار تعداد مشاهده مقاله: 1,444 تعداد دریافت فایل اصل مقاله: 752 |
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