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Xu, Hongyan, Yang, Yueqing, Wu, Qianhong, Zhang, Yan. (1398). Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis. سامانه مدیریت نشریات علمی, 17(1), 1-13. doi: 10.22034/iji.2020.80290
Hongyan Xu; Yueqing Yang; Qianhong Wu; Yan Zhang. "Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis". سامانه مدیریت نشریات علمی, 17, 1, 1398, 1-13. doi: 10.22034/iji.2020.80290
Xu, Hongyan, Yang, Yueqing, Wu, Qianhong, Zhang, Yan. (1398). 'Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis', سامانه مدیریت نشریات علمی, 17(1), pp. 1-13. doi: 10.22034/iji.2020.80290
Xu, Hongyan, Yang, Yueqing, Wu, Qianhong, Zhang, Yan. Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis. سامانه مدیریت نشریات علمی, 1398; 17(1): 1-13. doi: 10.22034/iji.2020.80290

Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis

Iranian Journal of Immunology
مقاله 1، دوره 17، شماره 1، خرداد 2020، صفحه 1-13    اصل مقاله (691.6 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2020.80290
نویسندگان
Hongyan Xu1؛ Yueqing Yang2؛ Qianhong Wu1؛ Yan Zhang* 1
1Tuberculosis Prevention and Control Hospital of Shaanxi Province, Xi'an City, Shaanxi
2Traditional Chinese Medicine Hospital of Shaanxi Province, Xi'an City, Shaanxi
چکیده
Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB). Objective: To determine the significance of Th2/Th1 ratio and concentration of PD-L1 in the pleural effusions for prediction of MDR-TB. Methods: We measured the ratio of Th2 to Th1 T cells from pleural effusions in 373 tuberculous pleuritis patients. We also measured the concentration of programmed death ligand-1 (PD-L1) in the pleural effusions of these patients. Afterwards, we determined the optimal cut-off value for predicting the occurrence of multi-drug resistant tuberculous based on the Youden index, diagnostic evaluation test, and receiver operation curve. Multiple logistic analysis was employed to identify the independent risk factors for MDR-TB occurrence. Results: The area under the curve (AUC) of the Th2 to Th1 ratio was 0.66 and the concentration of PD-L1 was 0.71. Based on the combined detection of PD-L1 concentration in pleural effusion and the Th2 to Th1 ratio, our AUC was 0.81 and had a specificity of 0.92. Only a combined detection was able to identify patients developing multidrug-resistant tuberculosis. Multiple logistic analysis showed that a high concentration of PD-L1 and a high Th2 to Th1 T ratio in pleural effusions were indicative of an immunocompromised status. Therefore, these measurements might be independent risk factors for the occurrence of multidrug-resistant tuberculous. Conclusion: Evaluation of immune status based on PD-L1 pleural concentration and Th2 to Th1 ratio might predict the risk of MDR-TB occurrence.
کلیدواژه‌ها
Drug Resistant؛ PD-L1؛ Th1؛ Th2؛ Tuberculosis
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