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Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats | ||
| Journal of Biomedical Physics and Engineering | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 18 فروردین 1399 اصل مقاله (898.75 K) | ||
| نوع مقاله: Original Research | ||
| نویسندگان | ||
S Sajadi 1؛ Gh Haddadi  2، 3؛ F Kadivar1، 4؛ R Fardid 2، 3
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| 1MSc, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2PhD, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3PhD, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4MSc, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region. Objective: This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat’s mediastinum region. Material and Methods: In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence. Results: In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (p <0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016). Conclusion: Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation. | ||
| کلیدواژه‌ها | ||
| Radiation؛ Heart Injury؛ Hesperidin | ||
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آمار تعداد مشاهده مقاله: 104 تعداد دریافت فایل اصل مقاله: 159 |
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