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Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. (1400). Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats. سامانه مدیریت نشریات علمی, 11(3), 377-388. doi: 10.31661/jbpe.v0i0.969
Somayeh Sajadi; Gholamhassan Haddadi; Fatemeh Kadivar; Reza Fardid. "Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats". سامانه مدیریت نشریات علمی, 11, 3, 1400, 377-388. doi: 10.31661/jbpe.v0i0.969
Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. (1400). 'Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats', سامانه مدیریت نشریات علمی, 11(3), pp. 377-388. doi: 10.31661/jbpe.v0i0.969
Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats. سامانه مدیریت نشریات علمی, 1400; 11(3): 377-388. doi: 10.31661/jbpe.v0i0.969

Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats

Journal of Biomedical Physics and Engineering
مقاله 13، دوره 11، شماره 3، شهریور 2021، صفحه 377-388    اصل مقاله (1021.44 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.969
نویسندگان
Somayeh Sajadi1؛ Gholamhassan Haddadi* 2، 3؛ Fatemeh Kadivar1، 4؛ Reza Fardid2، 3
1MSc, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
2PhD, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
3PhD, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4MSc, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region.
Objective: This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat’s mediastinum region.
Material and Methods: In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence.
Results: In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (p <0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016).
Conclusion: Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
کلیدواژه‌ها
Radiation؛ Heart Injury؛ Hesperidin
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