LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,203
تعداد مقالات10,960
تعداد مشاهده مقاله74,026,908
تعداد دریافت فایل اصل مقاله43,799,849
Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. (1400). Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats. سامانه مدیریت نشریات علمی, 11(3), 377-388. doi: 10.31661/jbpe.v0i0.969
Somayeh Sajadi; Gholamhassan Haddadi; Fatemeh Kadivar; Reza Fardid. "Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats". سامانه مدیریت نشریات علمی, 11, 3, 1400, 377-388. doi: 10.31661/jbpe.v0i0.969
Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. (1400). 'Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats', سامانه مدیریت نشریات علمی, 11(3), pp. 377-388. doi: 10.31661/jbpe.v0i0.969
Sajadi, Somayeh, Haddadi, Gholamhassan, Kadivar, Fatemeh, Fardid, Reza. Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats. سامانه مدیریت نشریات علمی, 1400; 11(3): 377-388. doi: 10.31661/jbpe.v0i0.969

Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats

Journal of Biomedical Physics and Engineering
مقاله 13، دوره 11، شماره 3، شهریور 2021، صفحه 377-388    اصل مقاله (1021.44 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.969
نویسندگان
Somayeh Sajadi1؛ Gholamhassan Haddadi* 2، 3؛ Fatemeh Kadivar1، 4؛ Reza Fardid2، 3
1MSc, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
2PhD, Department of Radiology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
3PhD, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4MSc, Ionizing and Non Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region.
Objective: This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat’s mediastinum region.
Material and Methods: In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence.
Results: In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (p <0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016).
Conclusion: Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
کلیدواژه‌ها
Radiation؛ Heart Injury؛ Hesperidin
سایر فایل های مرتبط با مقاله
مراجع
  1. Fuster V, Voute J. MDGs: chronic diseases are not on the agenda. Lancet. 2005;366:1512-4. doi: 10.1016/S0140-6736(05)67610-6. PubMed PMID: 16257330.
  2. Topol EJ, Leya F, Pinkerton CA, Whitlow PL, Hofling B, Simonton CA, et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease. N Engl J Med. 1993;329:221-7. doi: 10.1056/NEJM199307223290401. PubMed PMID: 8316266.
  3. Dale W, Gray LH, Meredith W. The inactivation of an enzyme (Carboxypeptidase) by X-and α-radiation. Philosophical Transactions of the Royal Society of London Series A. Mathematical and Physical Sciences. 1949;242:33-62. doi: 10.1098/rsta.1949.0004.
  4. Hosseinimehr SJ, Tavakoli H, Pourheidari G, Sobhani A, Shafiee A. Radioprotective effects of citrus extract against gamma-irradiation in mouse bone marrow cells. J Radiat Res. 2003;44:237-41. PubMed PMID: 14646227.
  5. Tiwari AK. Imbalance in antioxidant defence and human diseases: Multiple approach of natural antioxidants therapy. Curr Sci. 2001:1179-87.
  6. Lee Y-S, Huh J-Y, Nam S-H, Moon S-K, Lee S-B. Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori. Food Chem. 2012;135:2253-9. doi: 10.1016/j.foodchem.2012.07.007.
  7. Babuin L, Jaffe AS. Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ. 2005;173:1191-202.
  8. Horwich TB, Patel J, MacLellan WR, Fonarow GC. Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure. Circulation. 2003;108:833-8. doi: 10.1161/01.CIR.0000084543.79097.34. PubMed PMID: 12912820.
  9. Tommasini S, Calabro ML, Stancanelli R, Donato P, Costa C, Catania S, et al. The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin. J Pharm Biomed Anal. 2005;39:572-80. doi: 10.1016/j.jpba.2005.05.009. PubMed PMID: 15985355.
  10. Emim JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol. 1994;46:118-22. doi: 10.1111/j.2042-7158.1994.tb03753.x. PubMed PMID: 8021799.
  11. Garg A, Garg S, Zaneveld LJ, Singla AK. Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001;15:655-69. doi: 10.1002/ptr.1074. PubMed PMID: 11746857.
  12. Bayes-Genis A, Barallat J, Pascual D, Nunez J, Minana G, Sanchez-Mas J, et al. Rapid Fire 1–Acute Heart Failure. Eur J Heart Fail. 2015;17:5-441.
  13. Serin M, Gulbas H, Gurses I, Erkal HS, Yucel N. The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model. Int J Radiat Biol. 2007;83:187-93. doi: 10.1080/09553000601129093. PubMed PMID: 17378527.
  14. Hosseinimehr S, Nemati A. Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells. The British Journal of Radiology. 2006;79:415-8.
  15. Pradeep K, Park SH, Ko KC. Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur J Pharmacol. 2008;587:273-80. doi: 10.1016/j.ejphar.2008.03.052. PubMed PMID: 18485345.
  16. Kalpana KB, Devipriya N, Srinivasan M, Vishwanathan P, Thayalan K, Menon VP. Evaluating the radioprotective effect of hesperidin in the liver of Swiss albino mice. Eur J Pharmacol. 2011;658:206-12. doi: 10.1016/j.ejphar.2011.02.031. PubMed PMID: 21371459.
  17. Kuntic V, Brboric J, Holclajtner-Antunovic I, Uskokovic-Markovic S. Evaluating the bioactive effects of flavonoid hesperidin--a new literature data survey. Vojnosanit Pregl. 2014;71:60-5. doi: 10.2298/vsp1401060k. PubMed PMID: 24516992.
  18. Kalpana K, Devipriya N, Srinivasan M, Menon VP. Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2009;676:54-61. doi: 10.1016/j.mrgentox.2009.03.005.
  19. Dominello MM, Fountain MD, Rothstein SE, Cannon AC, Abernathy LM, Hoogstra D, et al. Radiation injury to cardiac arteries and myocardium is reduced by soy isoflavones. Journal of Radiation Oncology. 2017;6:307-15. doi: 10.1007/s13566-017-0301-z.
  20. Park SH, Pradeep K, Ko KC. Protective effect of hesperidin against γ-radiation induced oxidative stress in Sprague-Dawley rats. Pharm Biol. 2009;47:940-7. doi: 10.1080/13880200902950793.
  21. Hozayen WG, Abou Seif H. Protective effects of rutin and hesperidin against doxorubicin-induced lipodystrophy and cardiotoxicity in albino rats. J Am Sci. 2011;7:765-75.
  22. Rezaeyan A, Fardid R, Haddadi GH, Takhshid MA, Hosseinzadeh M, Najafi M, et al. Evaluating Radioprotective Effect of Hesperidin on Acute Radiation Damage in the Lung Tissue of Rats. J Biomed Phys Eng. 2016;6:165-74. PubMed PMID: 27853724. PubMed PMCID: PMC5106549.
  23. Ghorbani Zh, Fardid R, Haddadi GH, Derakhshanfar A, Kouhpayeh A, Haddadi Z. Histopathologic Evaluation of Radio- Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats. J Biomed Phys Eng. 2020;10(1):7-14. doi: 10.31661/jbpe.v0i0.832. PubMed PMID: 32158707. PubMed PMCID: PMC7036407.
  24. Hosseinimehr SJ, Mahmoudzadeh A, Ahmadi A, Mohamadifar S, Akhlaghpoor S. Radioprotective effects of hesperidin against genotoxicity induced by gamma-irradiation in human lymphocytes. Mutagenesis. 2009;24:233-5. doi: 10.1093/mutage/gep001. PubMed PMID: 19193695.
  25. Ahmed HM, Hussein MA, Alazonee AS. Radioprotective effect of hesperidin against gamma-irradiation-induced oxidative stress and biomechanical properties of bone in rats. Life Sci J. 2013;10:2857-65.
آمار
تعداد مشاهده مقاله: 4,135
تعداد دریافت فایل اصل مقاله: 1,033


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب