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Sarvepalli, Shashank, Lal, Pooja, Kamal, Afrin, Garber, Ari, McMichael, John, Morris-Stiff, Gareth, Vargo, John, Rothberg, Micheal, Rizk, Maged, Burke, Carol. (1398). Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps. سامانه مدیریت نشریات علمی, 8(1), 1-8. doi: 10.30476/acrr.2020.46438
Shashank Sarvepalli; Pooja Lal; Afrin Kamal; Ari Garber; John McMichael; Gareth Morris-Stiff; John Vargo; Micheal Rothberg; Maged Rizk; Carol Burke. "Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps". سامانه مدیریت نشریات علمی, 8, 1, 1398, 1-8. doi: 10.30476/acrr.2020.46438
Sarvepalli, Shashank, Lal, Pooja, Kamal, Afrin, Garber, Ari, McMichael, John, Morris-Stiff, Gareth, Vargo, John, Rothberg, Micheal, Rizk, Maged, Burke, Carol. (1398). 'Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps', سامانه مدیریت نشریات علمی, 8(1), pp. 1-8. doi: 10.30476/acrr.2020.46438
Sarvepalli, Shashank, Lal, Pooja, Kamal, Afrin, Garber, Ari, McMichael, John, Morris-Stiff, Gareth, Vargo, John, Rothberg, Micheal, Rizk, Maged, Burke, Carol. Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps. سامانه مدیریت نشریات علمی, 1398; 8(1): 1-8. doi: 10.30476/acrr.2020.46438

Left-Sided Diverticulosis is a Risk Factor for Distal Colon Polyps

Iranian Journal of Colorectal Research
مقاله 1، دوره 8، شماره 1، خرداد 2020، صفحه 1-8    اصل مقاله (582.12 K)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2020.46438
نویسندگان
Shashank Sarvepalli1؛ Pooja Lal* 2؛ Afrin Kamal3؛ Ari Garber4؛ John McMichael5؛ Gareth Morris-Stiff5؛ John Vargo4؛ Micheal Rothberg6؛ Maged Rizk4؛ Carol Burke4
1Dept. of Gastroenterology & Hepatology, Baylor College of Medicine
2Internal Medicine, Cleveland Clinic Foundation, OH. USA
3Division of Gastroenterology and Hepatology, Stanford University School of Medicine
4Dept. of Gastroenterology and Hepatology, Cleveland Clinic Foundation
5Dept. of General Surgery, Cleveland Clinic Foundation
6Medicine Institute, Cleveland Clinic Foundation
چکیده
BACKGROUND AND AIMS
Previous small to mid-sized studies have found an inconsistent relationship between diverticulosis and colon polyps. We assessed the odds of polyps in patients with left-sided diverticulosis (LDV) compared to patients without LDV, and if a predilection for polyps in the distal colon (DC) versus the proximal colon (PC) existed.
METHODS
In this case-control, retrospective study records of all patients in the Cleveland Clinic undergoing average-risk, screening colonoscopy between January 2011-August 2017 were identified. Baseline characteristics were described. Multivariate logistic regression analysis was performed to identify odds of polyps in PC and DC after adjusting for clinical and colonoscopic factors.
RESULTS
50,703 patients (mean age=60 years; 48% male) were included; 38.9% of patients had LDV. Compared to patients without LDV, those with LDV more often had adenomas (33.2% vs 27.8%; p <0.001), hyperplastic polyps (HPs) (18.3% vs 16.2%; p <0.001), and sessile serrated polyps (SSPs) (4.8% vs 4.3%; P=0.011). LDV was associated with adenomas in the DC (OR, 1.59; 95%CI, 1.52, 1.67) more than the PC (OR, 1.15; 95%CI, 1.10, 1.21), with HPs equally in the PC (OR, 1.27; 95%CI, 1.20, 1.34) and DC (OR, 1.28; 95%CI, 1.19, 1.38), and with SSPs in the DC only (OR, 1.50; 95%CI, 1.34, 1.67).
CONCLUSIONS
LDV is associated with a significantly increased risk of adenomas, HPs, and SSPs, but the association was stronger for adenomas in the DC. Careful inspection of the DC should be encouraged in patients with LDV. More research is needed to understand this phenomenon.
کلیدواژه‌ها
adenomas؛ colorectal cancer surveillance؛ sessile serrated polyps؛ sessile serrated polyps detection rate؛ adenoma detection rate
مراجع

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