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Shahverdi, Ehsan, Karami, Pedram, Tavakoli, Farzaneh, Maki, Massoumeh, Moazzami, Meysam, Feizi, Fatemeh, Salamati, Peyman, Lotfipour, Alireza, Ehsani, Mohammad Ali. (1399). Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X. سامانه مدیریت نشریات علمی, 11(2), 168-173. doi: 10.30476/mejc.2019.81253.0
Ehsan Shahverdi; Pedram Karami; Farzaneh Tavakoli; Massoumeh Maki; Meysam Moazzami; Fatemeh Feizi; Peyman Salamati; Alireza Lotfipour; Mohammad Ali Ehsani. "Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X". سامانه مدیریت نشریات علمی, 11, 2, 1399, 168-173. doi: 10.30476/mejc.2019.81253.0
Shahverdi, Ehsan, Karami, Pedram, Tavakoli, Farzaneh, Maki, Massoumeh, Moazzami, Meysam, Feizi, Fatemeh, Salamati, Peyman, Lotfipour, Alireza, Ehsani, Mohammad Ali. (1399). 'Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X', سامانه مدیریت نشریات علمی, 11(2), pp. 168-173. doi: 10.30476/mejc.2019.81253.0
Shahverdi, Ehsan, Karami, Pedram, Tavakoli, Farzaneh, Maki, Massoumeh, Moazzami, Meysam, Feizi, Fatemeh, Salamati, Peyman, Lotfipour, Alireza, Ehsani, Mohammad Ali. Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X. سامانه مدیریت نشریات علمی, 1399; 11(2): 168-173. doi: 10.30476/mejc.2019.81253.0

Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X

Middle East Journal of Cancer
مقاله 5، دوره 11، شماره 2 - شماره پیاپی 42، تیر 2020، صفحه 168-173    اصل مقاله (113.43 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2019.81253.0
نویسندگان
Ehsan Shahverdi* 1؛ Pedram Karami2؛ Farzaneh Tavakoli3؛ Massoumeh Maki4؛ Meysam Moazzami5؛ Fatemeh Feizi6؛ Peyman Salamati7؛ Alireza Lotfipour7؛ Mohammad Ali Ehsani7
1Department of Cardiology, Angiology and Sleep Medicine, Bonifatius Hospital Lingen, Lingen, Germany
2Department of Otorhinolaryngology-Head and Neck Surgery, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
3Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Nursing and Midwifery, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
5Department of Pediatrics, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran
6Department of Laboratory Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshi University of Medical Science, Tehran, Iran
7Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous group of lymphoid neoplasms resulting from the proliferation of malignant lymphoid cells. The aim of this study was to evaluate treatment-related complications in children with ALL receiving the Medical Research Council (MRC) UKALL X protocol.
Methods: In this retrospective cross-sectional study, children with ALL receiving the MRC UKALL X protocol from 2008 to 2015 in Bahrami University Hospital, Iran, were enrolled. The clinical and morphological features were analysed and treatment-related complications were assessed.
Results: Out of 67 children with ALL receiving the MRC UKALL X protocol, 44 (65.6 %) were boys and 23 (34.4%) were girls. Seven patients (10.7%) relapsed in the three years of diagnosis, and 50 children (74.6%) had an overall survival of three years. Average age in three-year-survival group and mortality group was 6.92 (SD: 3.96) and 6.35 (SD: 7.47), respectively (P= 0.38).
Conclusion: Overall survival and relapse rates in this study confirm that this protocol is an appropriate treatment strategy.
کلیدواژه‌ها
Acute lymphoblastic leukemia (ALL)؛ Mortality؛ MRC UKALL X؛ Neutropenia؛ Pediatric
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