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Ghasemi, Sh, Shabestani Monfared, A, Zabihi, E, Khoshbin Khoshnazar, A, Asadi, J, Abedian, Z, Borzoueisileh, S. (1399). Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon. سامانه مدیریت نشریات علمی, 10(2), 147-154. doi: 10.31661/jbpe.v0i0.715
Sh Ghasemi; A Shabestani Monfared; E Zabihi; A Khoshbin Khoshnazar; J Asadi; Z Abedian; S Borzoueisileh. "Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon". سامانه مدیریت نشریات علمی, 10, 2, 1399, 147-154. doi: 10.31661/jbpe.v0i0.715
Ghasemi, Sh, Shabestani Monfared, A, Zabihi, E, Khoshbin Khoshnazar, A, Asadi, J, Abedian, Z, Borzoueisileh, S. (1399). 'Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon', سامانه مدیریت نشریات علمی, 10(2), pp. 147-154. doi: 10.31661/jbpe.v0i0.715
Ghasemi, Sh, Shabestani Monfared, A, Zabihi, E, Khoshbin Khoshnazar, A, Asadi, J, Abedian, Z, Borzoueisileh, S. Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon. سامانه مدیریت نشریات علمی, 1399; 10(2): 147-154. doi: 10.31661/jbpe.v0i0.715

Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon

Journal of Biomedical Physics and Engineering
مقاله 5، دوره 10، شماره 2، تیر 2020، صفحه 147-154    اصل مقاله (570.42 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.715
نویسندگان
Sh Ghasemi1؛ A Shabestani Monfared* 2، 3؛ E Zabihi4؛ A Khoshbin Khoshnazar5؛ J Asadi6؛ Z Abedian7؛ S Borzoueisileh7، 8
1MSc, Student Research Committee, Babol University of Medical Sciences, Babol, Iran
2PhD, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3PhD, Department of Medical Physics Radio­biology and Radiation Protection, Faculty of Medicine, Babol Univer­sity of Medical Sciences, Babol, Iran
4PhD, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5PhD, Faculty of Medi­cine, Golestan University of Medical Sciences, Gorgan, Iran
6PhD, Biochemistry and Metabolic Disorders Re­search Center, Golestan University of Medical Sciences, Gorgan, Iran
7PhD Candidate, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medi­cal Sciences, Babol, Iran
8PhD Candidate, Student Research Committee, Babol University of Medical Sciences, Babol, Iran
چکیده
Background: Diazinon is one of the most common pesticides in the world playing a similar role to radiation and it could cause DNA breaks and genetic effects.
Objective: In this study, radiosensitivity of a lymphoblastic cell line pretreated by Diazinon was investigated.
Material and Methods: In this case-control study, the human lymphoblastic T-cell line was divided into 6 groups based on receiving radiation or/and Diazinon. After that, the DNA damage, in all of the groups, were counted by cytokinesis-block micronuclei assay using different indices.
Results: The mean frequency of micronuclei, nuclear bridges and nuclear buds in cell groups exposed by both Diazinon and radiation were remarkably higher than the other groups which just received radiation or Diazinon alone. The interaction between radiation and Diazinon treatment was statistically significant for NBUDS index.
Conclusion: The results indicated that the Diazinon contamination could affect the radiosensitivity index of cancerous cells while further molecular and in-vivo studies are needed to investigate genetic and toxic effects of Diazinon on DNA and its repair system.
کلیدواژه‌ها
Pesticides؛ Diazinon؛ Jurkat Cells؛ Radiotherapy؛ Radiation Tolerance
سایر فایل های مرتبط با مقاله
مراجع
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