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Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus | ||
| Journal of Dentistry | ||
| مقاله 10، دوره 21، شماره 4 - شماره پیاپی 69، اسفند 2020، صفحه 330-334 اصل مقاله (362.19 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2020.84667.1096 | ||
| نویسندگان | ||
| Maryam Mardani1؛ Shiva Torabi Ardakani2؛ Ladan Dastgheib3؛ Nasrin Hamidizadeh* 3 | ||
| 1Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Dept. of Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, which its etiology and pathogenesis are unclear. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular cross-talk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: Peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals. Serum samples were prepared from LP patients, using a commercial ELISA Kit, IL-22 concentration was measured in each serum sample. The obtained data were then analyzed using the Kruskal-Wallis one-way analysis of variance. Results: IL-22 serums level was significantly higher in patients with oral lichen planus than the healthy control group (p < 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p = 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral Lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus. | ||
| کلیدواژه‌ها | ||
| IL-22؛ Oral lichen planus؛ Cutaneous lichen planus؛ Serum | ||
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| مراجع | ||
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