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Ghaderi, S, Divband, B, Gharehaghaji, N. (1398). Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite. سامانه مدیریت نشریات علمی, 10(1), 103-110. doi: 10.31661/jbpe.v0i0.1254
S Ghaderi; B Divband; N Gharehaghaji. "Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite". سامانه مدیریت نشریات علمی, 10, 1, 1398, 103-110. doi: 10.31661/jbpe.v0i0.1254
Ghaderi, S, Divband, B, Gharehaghaji, N. (1398). 'Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite', سامانه مدیریت نشریات علمی, 10(1), pp. 103-110. doi: 10.31661/jbpe.v0i0.1254
Ghaderi, S, Divband, B, Gharehaghaji, N. Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite. سامانه مدیریت نشریات علمی, 1398; 10(1): 103-110. doi: 10.31661/jbpe.v0i0.1254

Magnetic Resonance Imaging Property of Doxorubicin-Loaded Gadolinium/13X Zeolite/Folic Acid Nanocomposite

Journal of Biomedical Physics and Engineering
مقاله 12، دوره 10، شماره 1، اردیبهشت 2020، صفحه 103-110    اصل مقاله (692 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1254
نویسندگان
S Ghaderi1، 2؛ B Divband3، 4؛ N Gharehaghaji* 5
1MSc, Medical Radiation Sciences Research Team, Tabriz University of Medical Sciences, Tabriz, Iran
2MSc, Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
3PhD, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4PhD, Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
5PhD, Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Magnetic resonance imaging (MRI) using nanostructures has been a proper method for tumor targeting purposes. Different MRI nanomaterials, targeting agents and anticancer drugs have been used for targeting of tumors.
Objectives: This study aims to consider the MRI property of doxorubicin (DOX)-loaded gadolinium/13X zeolite/folic acid (Gd3+/13X/FA) nanocomposite.
Material and Methods: In this in vitro study, Gd3+/13X/FA/DOX nanocomposite was prepared and the X-ray diffraction, scanning electron microscopy and MTT assay were conducted to evaluate the physicochemical properties of the nanocomposite. MRI was performed at 25°C using a 1.5 T clinical system to determine the T1 relaxation times and subsequently, the T1 relaxivity.
Results: The size of the nanocomposite was in the range of 80-200 nm. The nanocomposite without DOX loading (Gd3+/13X/FA) showed compatibility for A549 cells for all concentrations while DOX-loaded nanocomposite was toxic for 62% of the cells at the concentration of 0.4 mg/ml. The T1 relaxivity of Gd3+/13X/FA/DOX nanocomposite was 4.0401 mM-1s-1.
Conclusion: Gd3+/13X/FA/DOX nanocomposite shows a T1 relaxivity similar to the conventional gadolinium chelates, and a successful DOX loading.
کلیدواژه‌ها
Magnetic Resonance Imaging؛ Relaxivity؛ Gadolinium؛ Doxorubicin؛ Folic Acid؛ 13X zeolite
مراجع
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