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Hadinia, Abolghasem, Doustimotlagh, Amir Hossein, Goodarzi, Hamed Reza, Arya, Arash, Jafarinia, Mojtaba. (1398). Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. سامانه مدیریت نشریات علمی, 16(4), 327-333. doi: 10.22034/iji.2019.80284
Abolghasem Hadinia; Amir Hossein Doustimotlagh; Hamed Reza Goodarzi; Arash Arya; Mojtaba Jafarinia. "Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis". سامانه مدیریت نشریات علمی, 16, 4, 1398, 327-333. doi: 10.22034/iji.2019.80284
Hadinia, Abolghasem, Doustimotlagh, Amir Hossein, Goodarzi, Hamed Reza, Arya, Arash, Jafarinia, Mojtaba. (1398). 'Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis', سامانه مدیریت نشریات علمی, 16(4), pp. 327-333. doi: 10.22034/iji.2019.80284
Hadinia, Abolghasem, Doustimotlagh, Amir Hossein, Goodarzi, Hamed Reza, Arya, Arash, Jafarinia, Mojtaba. Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. سامانه مدیریت نشریات علمی, 1398; 16(4): 327-333. doi: 10.22034/iji.2019.80284

Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Iranian Journal of Immunology
مقاله 7، دوره 16، شماره 4، اسفند 2019، صفحه 327-333    اصل مقاله (210.37 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2019.80284
نویسندگان
Abolghasem Hadinia1؛ Amir Hossein Doustimotlagh* 2، 3؛ Hamed Reza Goodarzi1؛ Arash Arya4؛ Mojtaba Jafarinia1
1Department of Genetic, Marvdasht branch, Islamic Azad University, Marvdasht, Iran
2Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
3Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
4Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
چکیده
Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1b, IL-6, and TNF-a were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1b and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-a levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.
کلیدواژه‌ها
Interleukin-1β؛ Interleukin-6؛ Non-Alcoholic Fatty Liver؛ Non-Alcoholic Steatohepatitis؛ Tumor Necrosis Factor-α
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