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Ben Dhifallah, Imene, Borhani-Haghighi, Afshin, Hamzaoui, Agnes, Hamzaoui, Kamel. (1398). Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease. سامانه مدیریت نشریات علمی, 16(4), 299-310. doi: 10.22034/iji.2019.80281
Imene Ben Dhifallah; Afshin Borhani-Haghighi; Agnes Hamzaoui; Kamel Hamzaoui. "Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease". سامانه مدیریت نشریات علمی, 16, 4, 1398, 299-310. doi: 10.22034/iji.2019.80281
Ben Dhifallah, Imene, Borhani-Haghighi, Afshin, Hamzaoui, Agnes, Hamzaoui, Kamel. (1398). 'Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease', سامانه مدیریت نشریات علمی, 16(4), pp. 299-310. doi: 10.22034/iji.2019.80281
Ben Dhifallah, Imene, Borhani-Haghighi, Afshin, Hamzaoui, Agnes, Hamzaoui, Kamel. Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease. سامانه مدیریت نشریات علمی, 1398; 16(4): 299-310. doi: 10.22034/iji.2019.80281

Decreased Level of IL-37 Correlates Negatively with Inflammatory Cytokines in Cerebrospinal Fluid of Patients with Neuro-Behcet’s Disease

Iranian Journal of Immunology
مقاله 4، دوره 16، شماره 4، اسفند 2019، صفحه 299-310    اصل مقاله (412.3 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80281
نویسندگان
Imene Ben Dhifallah1؛ Afshin Borhani-Haghighi2؛ Agnes Hamzaoui3، 4؛ Kamel Hamzaoui* 3، 4
1Institut Pasteur de Tunis, Tunis, Tunisia
2Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Unit Research 12SP15 "Homeostasis and Molecular Dysfunction in the lung" Abderrahman Mami Hospital, Pavillon B, Ariana, Tunis, Tunisia
4El Manar Tunis University, Faculty of Medicine of Tunis, Department of Immunology and Basic Sciences, Tunis, Tunisia
چکیده
Background: Behçet's disease (BD) is a systemic inflammatory disease with a chronic, relapsing-remitting course of unknown etiology. Neuro-Behcet’s disease (NBD) induce serious CNS complications and are known to be the main cause of long-term morbidity and mortality. IL‐37 is a natural suppressor of innate inflammation which its role in NBD has not been fully understood. Objective: To determine the expression of IL-37 in cerebrospinal fluid (CSF) and its relationship with other inflammatory cytokines. Methods: Level of IL-37, IL-6, IL-17, IL-21, TSLP and TGF-β were measured in CSF of 22 patients with NBD and 12 non-inflammatory neurological disease (NIND) and 10 headache attributed to Behçet's disease (HaBD) by enzyme‐linked immunosorbent assay (ELISA). In addition, IL-37 mRNA relative expression was detected by quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). Results: CSF level and mRNA expression of IL‐37 were elevated in NBD patients compared to those in NIND and HaBD patients. Levels of IL-6, IL-17, IL-21 and TSLP were found to be increased in NBD patients and were inversely associated with IL-37 level. Moreover, TGF-β level in CSF of NBD patients was positively correlated with IL-37 levels. IL-37 increased significantly after treatment and in remission group, but TGF-β was only increased in treatment group. Conclusion: IL‐37 expression increased in NBD patients, and correlated with disease activity. Our data conclude that IL-37 could be a disease marker in NBD, however it requires further studies.
کلیدواژه‌ها
Interlukine-37؛ Inflammatory Cytokines؛ Neuro-Behçet’s Disease
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