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Rezaeifard, Somayeh, Safaei, Akbar, Talei, Abdolrasoul, Faghih, Zahra, Erfani, Nasrollah. (1398). NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 16(4), 291-298. doi: 10.22034/iji.2019.80280
Somayeh Rezaeifard; Akbar Safaei; Abdolrasoul Talei; Zahra Faghih; Nasrollah Erfani. "NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer". سامانه مدیریت نشریات علمی, 16, 4, 1398, 291-298. doi: 10.22034/iji.2019.80280
Rezaeifard, Somayeh, Safaei, Akbar, Talei, Abdolrasoul, Faghih, Zahra, Erfani, Nasrollah. (1398). 'NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer', سامانه مدیریت نشریات علمی, 16(4), pp. 291-298. doi: 10.22034/iji.2019.80280
Rezaeifard, Somayeh, Safaei, Akbar, Talei, Abdolrasoul, Faghih, Zahra, Erfani, Nasrollah. NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 1398; 16(4): 291-298. doi: 10.22034/iji.2019.80280

NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer

Iranian Journal of Immunology
مقاله 3، دوره 16، شماره 4، اسفند 2019، صفحه 291-298    اصل مقاله (280.89 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80280
نویسندگان
Somayeh Rezaeifard1؛ Akbar Safaei2؛ Abdolrasoul Talei3؛ Zahra Faghih1؛ Nasrollah Erfani* 1، 4
1Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLNs) of patients with breast cancer (BC) and their association with different clinic-pathological features of the patients. Methods: Axillary lymph nodes were obtained from 30 Iranian women with breast cancer. After routine pathological evaluations, mononuclear cells were separated from their lymph nodes and incubated with appropriate fluorochrome conjugated monoclonal antibodies specific for CD3, HLA-DR, CD16/56, and Vα24Jα18-TCR. Data were collected on a four-color flow cytometer and analyzed by CellQuest software. Results: The mean percentages of NK (CD3-CD16/56+), NKT (CD3+CD16/56+) and iNKT (Vα24Jα18-TCR+) cells in TDLNs mononuclear cells of BC patients were 2.04%, 2.44% and 0.1%, respectively. A significant decrease in the percentages of NK and iNKT subsets in patients with grade I was observed compared to grade III (p=0.03 and p=0.01, respectively). Moreover, NK cells were increased in patients with grade III of BC compared to grade II (p= 0.003). Conclusion: The increase in the percentage of NK and iNKT cells in TDLNs of patients with higher grade of BC might suggest a suppressive phenotype for these cells in breast cancer, which merit more functional investigation.
کلیدواژه‌ها
Breast Cancer؛ Lymph Nodes؛ Invariant-NKT Cells؛ NK Cells؛ NKT Cells
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