LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,092
تعداد مقالات10,022
تعداد مشاهده مقاله27,201,367
تعداد دریافت فایل اصل مقاله7,463,508
Sutresno, A, Haryanto, F, Viridi, S, Arif, I. (1399). Influence Blocking by Gadolinium in Calcium Diffusion on Synapse Model: A Monte Carlo Simulation Study. سامانه مدیریت نشریات علمی, 10(3), 251-260. doi: 10.31661/jbpe.v0i0.1155
A Sutresno; F Haryanto; S Viridi; I Arif. "Influence Blocking by Gadolinium in Calcium Diffusion on Synapse Model: A Monte Carlo Simulation Study". سامانه مدیریت نشریات علمی, 10, 3, 1399, 251-260. doi: 10.31661/jbpe.v0i0.1155
Sutresno, A, Haryanto, F, Viridi, S, Arif, I. (1399). 'Influence Blocking by Gadolinium in Calcium Diffusion on Synapse Model: A Monte Carlo Simulation Study', سامانه مدیریت نشریات علمی, 10(3), pp. 251-260. doi: 10.31661/jbpe.v0i0.1155
Sutresno, A, Haryanto, F, Viridi, S, Arif, I. Influence Blocking by Gadolinium in Calcium Diffusion on Synapse Model: A Monte Carlo Simulation Study. سامانه مدیریت نشریات علمی, 1399; 10(3): 251-260. doi: 10.31661/jbpe.v0i0.1155

Influence Blocking by Gadolinium in Calcium Diffusion on Synapse Model: A Monte Carlo Simulation Study

Journal of Biomedical Physics and Engineering
مقاله 2، دوره 10، شماره 3، مرداد و شهریور 2020، صفحه 251-260    اصل مقاله (1.6 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1155
نویسندگان
A Sutresno* ؛ F Haryanto؛ S Viridi؛ I Arif
PhD, Nuclear Physics and Biophysics Research Division, Faculty of Mathematics and Natural Sciences, Institute Teknologi Bandung Jl. Ganesha 10 Bandung 40132, Indonesia
چکیده
Background: Gadolinium (Gd3+) is a chemical element belonging to the lanthanide group and commonly used in magnetic resonance imaging (MRI) as a contrast agent. However, recently, gadolinium has been reported deposition in the body after a patient receives multiple injections. Gadolinium is a potent block and competes with calcium diffusion into the presynaptic. There has not been a precise mechanism of gadolinium blocking calcium channel as a channel of calcium diffusion to presynaptic until now.
Objective: This study aims to investigate the mechanism of calcium influx model and the effect of neurotransmitter release to the synaptic cleft influenced by the presence of Gd3+.
Material and Methods: Monte Carlo Cell simulation was used to analyze simulation and also Blender was used to create and visualize the model for synapse. The synapse modeled by a form resembling the actual synapse base on a spherical shape.
Results: The presence of gadolinium around the presynaptic has been disturbing diffusion of calcium influx presynaptic. The result shows that the presence of gadolinium around the presynaptic has caused a decrease in the amount of calcium influx presynaptic. These factors contribute to reducing the establishment of the active membrane, then the amount of synaptic vesicle docking and finally the amount of released neurotransmitter.
Conclusion: Gadolinium and calcium compete with each other across of calcium channel. The presence of gadolinium has caused a chain effect for signal transmission at the chemical synapse, reducing the amount of active membrane, synaptic vesicle docking, and releasing neurotransmitter.
کلیدواژه‌ها
Monte Carlo Cell؛ Synapses؛ Diffusion؛ Contrast Agents؛ Gadolinium Blocking؛ Gadolinium
سایر فایل های مرتبط با مقاله
مراجع
  1. Lohrke J, Frenzel T, Endrikat J, Alves FC, Grist TM, Law M, et al. 25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives. Adv Ther. 2016;33:1-28. doi: 10.1007/s12325-015-0275-4. PubMed PMID: 26809251.PubMed PMCID: PMC4735235.
  2. Aime S, Caravan P. Biodistribution of gadolinium-based contrast agents, including gadolinium deposition. J Magn Reson Imaging. 2009;30:1259-67. doi: 10.1002/jmri.21969. PubMed PMID: 19938038. PubMed PMCID: PMC2822463.
  3. Morcos S. Extracellular gadolinium contrast agents: differences in stability. Eur J Radiol. 2008;66:175-9. doi: 10.1016/j.ejrad.2008.01.025.
  4. Kanda T, Oba H, Toyoda K, Kitajima K, Furui S. Brain gadolinium deposition after administration of gadolinium-based contrast agents. Jpn J Radiol. 2016;34:3-9. doi: 10.1007/s11604-015-0503-5. PubMed PMID: 26608061.
  5. Wiginton CD, Kelly B, Oto A, Jesse M, Aristimuno P, Ernst R, et al. Gadolinium-based contrast exposure, nephrogenic systemic fibrosis, and gadolinium detection in tissue. AJR Am J Roentgenol. 2008;190:1060-8. doi: 10.2214/AJR.07.2822. PubMed PMID: 18356456.
  6. Bourne G, Trifaro J. The gadolinium ion: a potent blocker of calcium channels and catecholamine release from cultured chromaffin cells. Neuroscience. 1982;7:1615-22. doi: 10.1016/0306-4522(82)90019-7.
  7. Hasebroock KM, Serkova NJ. Toxicity of MRI and CT contrast agents. Expert Opin Drug Metab Toxicol. 2009;5:403-16. doi: 10.1517/17425250902873796. PubMed PMID: 19368492.
  8. Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology. 2014;270:834-41. doi: 10.1148/radiol.13131669. PubMed PMID: 24475844.
  9. Kanda T, Oba H, Toyoda K, Kitajima K, Furui S. Brain gadolinium deposition after administration of gadolinium-based contrast agents. Jpn J Radiol. 2016;34:3-9. doi: 10.1007/s11604-015-0503-5. PubMed PMID: 26608061.
  10. Barbieri S, Schroeder C, Froehlich JM, Pasch A, Thoeny HC. High signal intensity in dentate nucleus and globus pallidus on unenhanced T1-weighted MR images in three patients with impaired renal function and vascular calcification. Contrast Media Mol Imaging. 2016;11:245-50. doi: 10.1002/cmmi.1683. PubMed PMID: 26929131. PubMed PMCID: PMC5066707.
  11. Yang XC, Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science. 1989;243:1068-71. doi: 10.1126/science.2466333. PubMed PMID: 2466333.
  12. Sudhof TC. Calcium control of neurotransmitter release. Cold Spring Harb Perspect Biol. 2012;4:a011353. doi: 10.1101/cshperspect.a011353. PubMed PMID: 22068972. PubMed PMCID: PMC3249630.
  13. Purves D, Augustine G, Fitzpatrick D, Hall W, LaMantia A, McNamara J, et al. Neurosciences. 3th ed. Sunderland: Sinauer Associates Inc. 2004. p. 93.
  14. Tarr TB, Wipf P, Meriney SD. Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome. Mol Neurobiol. 2015;52:456-63. doi: 10.1007/s12035-014-8887-2. PubMed PMID: 25195700. PubMed PMCID: PMC4362862.
  15. Bartol Jr TM, Land BR, Salpeter EE, Salpeter MM. Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophys J. 1991;59:1290-307. doi: 10.1016/S0006-3495(91)82344-X. PubMed PMID: 1873466. PubMed PMCID: PMC1281209.
  16. Dilger JP. Monte Carlo simulation of buffered diffusion into and out of a model synapse. Biophys J. 2010;98:959-67. doi: 10.1016/j.bpj.2009.11.034. PubMed PMID: 20303853. PubMed PMCID: PMC2849082.
  17. Sutresno A, Haryanto F, Viridi S, Arif I, editors. Diffusion and Interaction between ion Ca2+ and ion Gd3+ in a Model Synapse: A Monte Carlo Study. Journal of Physics: Conference Series; IOP Publishing; 2019. doi: 10.1088/1742-6596/1127/1/012006.
  18. Donahue BS, Abercrombie RF. Free diffusion coefficient of ionic calcium in cytoplasm. Cell Calcium. 1987;8:437-48. doi: 10.1016/0143-4160(87)90027-3. PubMed PMID: 3435913.
  19. Ermakov YA, Kamaraju K, Sengupta K, Sukharev S. Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids. Biophys J. 2010;98:1018-27. doi: 10.1016/j.bpj.2009.11.044. PubMed PMID: 20303859. PubMed PMCID: PMC2849073.
  20. Berg HC. Random walks in biology. Princeton University Press; 1993.
  21. Crank J. The mathematics of diffusion. 2nd ed. Oxford: Oxford university press; 1975. p. 42.
  22. Rusakov DA. Ca2+-dependent mechanisms of presynaptic control at central synapses. Neuroscientist. 2006;12(4):317-326. doi: 10.1177/1073858405284672.
  23. Malasics A, Boda D, Valisko M, Henderson D, Gillespie D. Simulations of calcium channel block by trivalent cations: Gd3+ competes with permeant ions for the selectivity filter. BBA – Biomembranes. 2010;1798(11):2013-2021. doi: 10.1016/j.bbamem.2010.08.001.
آمار
تعداد مشاهده مقاله: 1,515
تعداد دریافت فایل اصل مقاله: 641


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب