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Mortezazadeh, T, Gholibegloo, E, Riyahi Alam, N, Haghgoo, S, Musa, A E, Khoobi, M. (1398). Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI. سامانه مدیریت نشریات علمی, 10(1), 25-38. doi: 10.31661/jbpe.v0i0.1018
T Mortezazadeh; E Gholibegloo; N Riyahi Alam; S Haghgoo; A E Musa; M Khoobi. "Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI". سامانه مدیریت نشریات علمی, 10, 1, 1398, 25-38. doi: 10.31661/jbpe.v0i0.1018
Mortezazadeh, T, Gholibegloo, E, Riyahi Alam, N, Haghgoo, S, Musa, A E, Khoobi, M. (1398). 'Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI', سامانه مدیریت نشریات علمی, 10(1), pp. 25-38. doi: 10.31661/jbpe.v0i0.1018
Mortezazadeh, T, Gholibegloo, E, Riyahi Alam, N, Haghgoo, S, Musa, A E, Khoobi, M. Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI. سامانه مدیریت نشریات علمی, 1398; 10(1): 25-38. doi: 10.31661/jbpe.v0i0.1018

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

Journal of Biomedical Physics and Engineering
مقاله 4، دوره 10، شماره 1، فروردین و اردیبهشت 2020، صفحه 25-38    اصل مقاله (1.45 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.1018
نویسندگان
T Mortezazadeh1، 2؛ E Gholibegloo3؛ N Riyahi Alam* 1؛ S Haghgoo4؛ A E Musa1؛ M Khoobi3
1PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
2PhD, Department of Medical Physics, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran
3PhD, Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center (MBRC), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4PhD, Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Tehran, Iran
چکیده
Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.
Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd2O3) coated polycyclodextrin (PCD) and modified with glucose (Gd2O3@PCD-Glu) for the targeting of overexpressed glucose receptors.
Material and Methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd2O3@PCD-Glu NPs. Furthermore, the capacity of transporting Gd2O3@PCD-Glu NPs to tumor cells was evaluated.
Results: It was found that the acquired MRI T1 signal intensity of MDA-MB-231 cells that were treated with the Gd2O3@PCD-Glu NPs increased significantly. Based on the results obtained, Gd2O3@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis.
Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.
کلیدواژه‌ها
Magnetic Resonance Imaging؛ Gadolinium؛ Contrast media
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