پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,089 |
| تعداد مقالات | 9,995 |
| تعداد مشاهده مقاله | 26,336,767 |
| تعداد دریافت فایل اصل مقاله | 7,273,134 |
Mel-CAM Expression in Common Oral Carcinomas | ||
| Journal of Dentistry | ||
| مقاله 3، دوره 21، شماره 3 - شماره پیاپی 68، آذر 2020، صفحه 184-189 اصل مقاله (567.06 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2019.77873.0 | ||
| نویسندگان | ||
| Nafise Shamloo1؛ Nasim Taghavi1؛ Samira Behrad2؛ Ali Dehghani Nazhvani* 3 | ||
| 1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| 2Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Semnan University of Medical Sciences, Semnan, Iran | ||
| 3Dept. of Oral and Maxillofacial Pathology, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| atement of the Problem: Mel-CAM (CD146, MUC18) is a 113-kD heterophilic cell-cell adhesion glycoprotein found in normal and tumoral tissues. Purpose: The aim of this study is assessing the expression of Mel-CAM in common oral carcinomas like salivary gland mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC) to differentiate the OSCC from high-grade MEC. Materials and Method: This study was performed on 19 specimens of MEC and 17 specimens of OSCC, which were retrieved from the archive of Department of Pathology of Taleghani Hospital, Tehran, Iran. Immunohistochemical staining was performed by using antibody against CD146. The data was analyzed by using SPSS software through Mann-Whitney, Spearman's correlation coefficient, and Kruskal-Wallis tests. Results: Mel-CAM was expressed in all MEC samples and 10 OSCC cases. The two groups were significantly different regarding the CD146 expression (p = 0.035). Furthermore, the CD146 expression was found to be significantly correlated with the invasion mode (p = 0.002), tumor size (p = 0.012), and histologic grade (p = 0.024) in OSCC group. No significant correlation existed between the expression, intensity and location with the histologic grade of MEC (p > 0.05). Nor was any significant correlation detected between the CD146 expression and lymph node metastasis in neither group. Conclusion: Regarding the significant correlation between the CD146 expression and the prognostic factors in OSCC, this marker may predict the prognosis in OSCC patients, but not the MEC lesions. It cannot be used for differentiating high-grade MEC and OSCC. | ||
| کلیدواژه‌ها | ||
| Mel-CAM؛ Mucoepidermoid carcinoma؛ Oral squamous cell carcinoma؛ Salivary glands | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
1. Neville BW. Oral & maxillofacial pathologyy. 4th ed. Missouri: Elsevier St. Louis; 2016. p. 454-455. . [Google Scholar]
2. Joseph A. Oral pathology clinical pathologic correlations. 7th ed. Missouri: Elsevier St. Louis; 2017. p. 209-210. [Google Scholar]
3. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25:835–845. [PubMed] [Google Scholar]
4. Ali S, Sarhan M, Palmer FL, Whitcher M, Shah JP, Patel SG, et al. Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands. Ann Surg Oncol. 2013;20:2396–2404. [PubMed] [Google Scholar]
5. McHugh CH, Roberts DB, El-Naggar AK, Hanna EY, Garden AS, Kies MS, et al. Prognostic factors in mucoepidermoid carcinoma of the salivary glands. Cancer. 2012;118:3928–3936. [PubMed] [Google Scholar]
6. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009; 45: 309–316. [PubMed] [Google Scholar]
7. Shih IM. The role of CD146 (Mel-CAM) in biology and pathology. J Pathol. 1999;189:4–11. [PubMed] [Google Scholar]
8. Lehmann JM, Riethmüller G, Johnson JP. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci USA. 1989;86:9891–9895. [PMC free article] [PubMed] [Google Scholar]
9. Shih IM, Nesbit M, Herlyn M, Kurman RJ. A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue. Mod Pathol. 1998;11:1098–1106. [PubMed] [Google Scholar]
10. Pires FR, Shih IeM, da Cruz Perez DE, de Almeida OP, Kowalski LP. Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma. Oral Oncol. 2003;39:277–281. [PubMed] [Google Scholar]
11. Zhang H, Zhang J, Wang Z, Lu D, Feng J, Yang D, et al. CD146 is a potential marker for the diagnosis of malignancy in cervical and endometrial cancer. Oncol Lett. 2013;5:1189–1194. [PMC free article] [PubMed] [Google Scholar]
12. Li W, Yang D, Wang S, Guo X, Lang R, Fan Y, et al. Increased expression of CD146 and microvessel density (MVD) in invasive micropapillary carcinoma of the breast: Comparative study with invasive ductal carcinoma-not otherwise specified. Pathol Res Pract. 2011;207:739–746. [PubMed] [Google Scholar]
13. Wu GJ, Fu P, Chiang CF, Huss WJ, Greenberg NM, Wu MW. Increased expression of MUC18 correlates with the metastatic progression of mouse prostate adenocarcinoma in the TRAMP model. J Urol. 2005;173:1778–1783. [PubMed] [Google Scholar]
14. Tian B, Zhang Y, Li N. CD146 protein as a marker to predict postoperative liver metastasis in colorectal cancer. Cancer Biother Radiopharm. 2013;28:466–470. [PubMed] [Google Scholar]
15. Li Y, Yu JM, Zhan XM, Liu LL, Jin N, Zhang YX. Correlation of CD146 expression and clinicopathological characteristics in esophageal squamous cell carcinoma. Oncol Lett. 2014;8:859–863. [PMC free article] [PubMed] [Google Scholar]
16. Charalabopoulos K, Mittari E, Golias C, Peschos D, Batistatou A. Integrin receptors and extracellular matrix components in parotid neoplasms. Exp Oncol. 2005;27:2–6. [PubMed] [Google Scholar]
17. Zeng Q, Zhang P, Wu Z, Xue P, Lu D, Ye Z, et al. Quantitative proteomics reveals ER-α involvement in CD146-induced epithelial-mesenchymal transition in breast cancer cells. J Proteomics. 2014;103:153–169. [PubMed] [Google Scholar]
18. Ouhtit A, Gaur RL, Abd Elmageed ZY, Fernando A, Thouta R, Trappey AK, et al. Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146. Biochim Biophys Acta. 2009;1795:130–136. [PubMed] [Google Scholar]
19. Sato A, Torii I, Okamura Y, Yamamoto T, Nishigami T, Kataoka TR, et al. Immunocytochemistry of CD146 is useful to discriminate between malignant pleural mesothelioma and reactive mesothelium. Mod Pathol. 2010;23:1458–1466. [PubMed] [Google Scholar]
20. Mills L, Tellez C, Huang S, Baker C, McCarty M, Green L, et al. Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 2002;62:5106–5114. [PubMed] [Google Scholar] | ||
|
آمار تعداد مشاهده مقاله: 1,430 تعداد دریافت فایل اصل مقاله: 1,160 |
||
