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Majidi, Zahra, Sadati lamardi, Seyede Nargess, Mohajjel-Nayebi, Alireza, Vatankhah, Amir Mansour, Asnaashari, Solmaz, Zakeri-Milani, Parvin. (1399). Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats. سامانه مدیریت نشریات علمی, 45(3), 199-206. doi: 10.30476/ijms.2019.45805
Zahra Majidi; Seyede Nargess Sadati lamardi; Alireza Mohajjel-Nayebi; Amir Mansour Vatankhah; Solmaz Asnaashari; Parvin Zakeri-Milani. "Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats". سامانه مدیریت نشریات علمی, 45, 3, 1399, 199-206. doi: 10.30476/ijms.2019.45805
Majidi, Zahra, Sadati lamardi, Seyede Nargess, Mohajjel-Nayebi, Alireza, Vatankhah, Amir Mansour, Asnaashari, Solmaz, Zakeri-Milani, Parvin. (1399). 'Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats', سامانه مدیریت نشریات علمی, 45(3), pp. 199-206. doi: 10.30476/ijms.2019.45805
Majidi, Zahra, Sadati lamardi, Seyede Nargess, Mohajjel-Nayebi, Alireza, Vatankhah, Amir Mansour, Asnaashari, Solmaz, Zakeri-Milani, Parvin. Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats. سامانه مدیریت نشریات علمی, 1399; 45(3): 199-206. doi: 10.30476/ijms.2019.45805

Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats

Iranian Journal of Medical Sciences
مقاله 6، دوره 45، شماره 3، مرداد 2020، صفحه 199-206    اصل مقاله (922.91 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.45805
نویسندگان
Zahra Majidi1؛ Seyede Nargess Sadati lamardi* 1؛ Alireza Mohajjel-Nayebi2؛ Amir Mansour Vatankhah3؛ Solmaz Asnaashari3؛ Parvin Zakeri-Milani4
1Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Drug Applied Research Center, Department of Pharmacology and Toxicology, Tabriz University of Medical Sciences, Tabriz, Iran
3Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Liver and Gastrointestinal Diseases Research Center, Department of Pharmaceutics and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Heracleum persicum (H. persicum) is a medicinal herb used in Iranian traditional medicine for its anti-toxic property. It is commonly consumed in the form of food additives and as a medicinal herbal tonic to treat liver and kidney diseases. The present study aimed to investigate the anti-oxidant, anti-diabetic, and anti-hyperlipidemic effects of H. persicum hydroalcoholic extract in alloxan-induced diabetic rats.
Methods: Adult male Wistar rats (n=30) were assigned to five groups: a normal group, a diabetic control group, and three diabetic groups treated orally with 200 and 400 mg/kg of the extract and 5 mg/kg of glibenclamide, respectively, for two weeks. Blood glucose and bodyweight were measured at the end of each week. On day 15, blood samples were collected to measure the levels of insulin, insulin growth factor-I (IGF-I), antioxidant markers for malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), total antioxidant activity (TAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) using commercial kits. The data were analyzed using SPSS Software (version 22.0).
Results: Daily treatment with 400 mg/kg of the extract significantly reduced the blood glucose level (p <0.001) and improved bodyweight (P=0.002), insulin (p <0.001), IGF-I (P=0.024), SOD (P=0.001), GPx (P=0.009), MDA (p <0.001), TAS (P=0.006), TG (p <0.001), HDL (P=0.023), LDL (P=0.005), and VLDL (p <0.001) compared with the diabetic control group.
Conclusion: Beneficial effects of H. persicum for the treatment of diabetes were confirmed.
کلیدواژه‌ها
Heracleum persicum؛ Antioxidants؛ Blood glucose؛ Diabetes mellitus؛ Insulin؛ Insulin-like growth factor I
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مراجع
  1. Ozougwu J, Obimba K, Belonwu C, Unakalamba C. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. Journal of Physiology and Pathophysiology. 2013;4:46-57. doi: 10.5897/JPAP2013.0001.
  2. Thévenod F. Pathophysiology of diabetes mellitus type 2: roles of obesity, insulin resistance and β-cell dysfunction. Diabetes and Cancer. 2008;19:1-18. doi: 10.1159/000152019.
  3. Chukwunonso Obi B, Chinwuba Okoye T, Okpashi VE, Nonye Igwe C, Olisah Alumanah E. Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats. J Diabetes Res. 2016;2016:1635361. doi: 10.1155/2016/1635361. PubMed PMID: 26824037; PubMed Central PMCID: PMCPMC4707348.
  4. Lee SY, Park SL, Hwang JT, Yi SH, Nam YD, Lim SI. Antidiabetic Effect of Morinda citrifolia (Noni) Fermented by Cheonggukjang in KK-A(y) Diabetic Mice. Evid Based Complement Alternat Med. 2012;2012:163280. doi: 10.1155/2012/163280. PubMed PMID: 22969823; PubMed Central PMCID: PMCPMC3434424.
  5. Venkatesh S, Madhava Reddy B, Dayanand Reddy G, Mullangi R, Lakshman M. Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of action. J Nat Med. 2010;64:295-304. doi: 10.1007/s11418-010-0406-9. PubMed PMID: 20238178.
  6. Fröberg L. Heracleum L. Flora Nordica (Thymelaeaceae to Apiaceae). Stockholm: The Swedish Museum of Natural History; 2010. p. 224-34.
  7. Aghili M. Makhzan-al-Advia. In: Rahimi R, Shams Ardekani MR, Farjadmand F, editors. Tehran: Tehran University of Medical Sciences; 2009. p. 201-2. Persian.
  8. Sharififar F, Pournourmohammadi S, Rastegarianzadeh R, Ranjbaran O, Purhemmaty A. Immunomodulatory activity of aqueous extract of Heracleum persicum Desf. in mice. Iran J Pharm Res. 2010;8:287-92.
  9. Sayyah M, Moaied S, Kamalinejad M. Anticonvulsant activity of Heracleum persicum seed. J Ethnopharmacol. 2005;98:209-11. doi: 10.1016/j.jep.2004.12.026. PubMed PMID: 15763386.
  10. Aynehchi Y, Aliabadi Z, Salehi Surmaghi MH. Furanocoumarines in the roots of Heracleum persicum DESF. Acta Horticulture. 1978;73:103-8. doi: 10.17660/ActaHortic.1978.73.13.
  11. Radjabian T, Salimi A, Rahmani N. Essential-oil composition of the fruits of six Heracleum L. species from Iran: chemotaxonomic significance. Chem Biodivers. 2014;11:1945-53. doi: 10.1002/cbdv.201400085. PubMed PMID: 25491338.
  12. Tunçtürk M, Özgökçe F. Chemical composition of some Apiaceae plants commonly used in herby cheese in Eastern Anatolia. Turkish Journal of Agriculture and Forestry. 2015;39:55-62. doi: /10.3906/tar-1406-153.
  13. Dehghan H, Sarrafi Y, Salehi P. Antioxidant and antidiabetic activities of 11 herbal plants from Hyrcania region, Iran. J Food Drug Anal. 2016;24:179-88. doi: 10.1016/j.jfda.2015.06.010. PubMed PMID: 28911402.c
  14. Hajhashemi V, Sajjadi SE, Heshmati M. Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. J Ethnopharmacol. 2009;124:475-80. doi: 10.1016/j.jep.2009.05.012. PubMed PMID: 19467316.
  15. Panahi Y, Pishgoo B, Dadjoo Y, Saburi A. OP-140 the effects of heracleum persicum extract as an adjunctive therapy on dyslipidemia; a randomized open-label clinical trial. Int J Cardiol. 2013;163:S55. doi: 10.1016/S0167-5273(13)70141-4.
  16. Olfert ED, Cross BM, McWilliam AA. Guide to the care and use of experimental animals Vol 1. 2nd ed. Ottawa: McWilliam; 1983.
  17. Ahmed S, Mundhe N, Borgohain M, Chowdhury L, Kwatra M, Bolshette N, et al. Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. Inflammation. 2016;39:1783-97. doi: 10.1007/s10753-016-0413-4. PubMed PMID: 27492452.
  18. Kim U, Lee T. Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat. Eur J Neurosci. 2012;35:1253-69. doi: 10.1111/j.1460-9568.2012.08030.x. PubMed PMID: 22512256.
  19. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158-69. PubMed PMID: 6066618.
  20. Crosti N, Servidei T, Bajer J, Serra A. Modification of the 6-hydroxydopamine technique for the correct determination of superoxide dismutase. J Clin Chem Clin Biochem. 1987;25:265-6. PubMed PMID: 3114411.
  21. Jowko E, Dlugolecka B, Makaruk B, Cieslinski I. The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. Eur J Nutr. 2015;54:783-91. doi: 10.1007/s00394-014-0757-1. PubMed PMID: 25120110; PubMed Central PMCID: PMCPMC4500852.
  22. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-8. doi: 10.1016/0003-2697(79)90738-3. PubMed PMID: 36810.
  23. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502. PubMed PMID: 4337382.
  24. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001;50:537-46. PubMed PMID: 11829314.
  25. Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012;2:320-30. doi: 10.1016/S2221-1691(12)60032-X. PubMed PMID: 23569923; PubMed Central PMCID: PMCPMC3609288.
  26. Coman C, Rugina OD, Socaciu C. Plants and natural compounds with antidiabetic action. Not Bot Horti Agrobot Cluj Napoca. 2012;40:314-25.
  27. Zhang Y, Liu D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol. 2011;670:325-32. doi: 10.1016/j.ejphar.2011.08.011. PubMed PMID: 21914439.
  28. Cao H, Ji Y, Li W, Liu Y, Fu R, Xiang M. Protective Effects of the Total Coumarin Fraction of Urtica dentata on Experimental Diabetic Nephropathy In Vitro and In Vivo. Planta Med. 2015;81:1353-60. doi: 10.1055/s-0035-1557866. PubMed PMID: 26366750.
  29. Kang KS, Lee W, Jung Y, Lee JH, Lee S, Eom DW, et al. Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice. J Agric Food Chem. 2014;62:2069-76. doi: 10.1021/jf403840c. PubMed PMID: 24484395.
  30. Hui H, Tang G, Go VL. Hypoglycemic herbs and their action mechanisms. Chin Med. 2009;4:11. doi: 10.1186/1749-8546-4-11. PubMed PMID: 19523223; PubMed Central PMCID: PMCPMC2704217.
  31. Dehghan H, Sarrafi Y, Salehi P, Ebrahimi SN. α-Glucosidase inhibitory and antioxidant activity of furanocoumarins from Heracleum persicum. Med Chem Res. 2017;26:849-55. doi: 10.1007/s00044-017-1796-y.
  32. Abbas A, Grant PJ, Kearney MT. Role of IGF-1 in glucose regulation and cardiovascular disease. Expert Rev Cardiovasc Ther. 2008;6:1135-49. doi: 10.1586/14779072.6.8.1135. PubMed PMID: 18793116.
  33. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006;147:4160-8. doi: 10.1210/en.2006-0251. PubMed PMID: 16777975.
  34. Sefi M, Fetoui H, Makni M, Zeghal N. Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem Toxicol. 2010;48:1986-93. doi: 10.1016/j.fct.2010.05.005. PubMed PMID: 20457207.
  35. Hajhashemi V, Dashti G, Saberi S, Malekjamshidi P. The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits. Avicenna J Phytomed. 2014;4:144-50. PubMed PMID: 25050312; PubMed Central PMCID: PMCPMC4104629.
  36. Kopin L, Lowenstein C. Dyslipidemia. Ann Intern Med. 2017;167:ITC81-ITC96. doi: 10.7326/AITC201712050. PubMed PMID: 29204622.
  37. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15:71. doi: 10.1186/s12937-016-0186-5. PubMed PMID: 27456681; PubMed Central PMCID: PMCPMC4960740.
  38. Najeeb Q, Bhaskar N, Masood I, Wadhwa S, Kaur H, Ishaq S. Malondialdehyde (MDA) Superoxide dismutase (SOD) levels-distinguishing parameters betweenbenign malignant pleural effusions. Free Radicals and Antioxidants. 2012;2:8-11. doi: 10.5530/ax.2012.2.2.2.
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