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Akbari, Fatemeh, Azadbakht, Mohammad, Dashti, Ayat, Vahedi, Lale, Davoodi, Ali. (1398). Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice. سامانه مدیریت نشریات علمی, 45(2), 134-139. doi: 10.30476/ijms.2019.45774
Fatemeh Akbari; Mohammad Azadbakht; Ayat Dashti; Lale Vahedi; Ali Davoodi. "Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice". سامانه مدیریت نشریات علمی, 45, 2, 1398, 134-139. doi: 10.30476/ijms.2019.45774
Akbari, Fatemeh, Azadbakht, Mohammad, Dashti, Ayat, Vahedi, Lale, Davoodi, Ali. (1398). 'Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice', سامانه مدیریت نشریات علمی, 45(2), pp. 134-139. doi: 10.30476/ijms.2019.45774
Akbari, Fatemeh, Azadbakht, Mohammad, Dashti, Ayat, Vahedi, Lale, Davoodi, Ali. Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice. سامانه مدیریت نشریات علمی, 1398; 45(2): 134-139. doi: 10.30476/ijms.2019.45774

Effect of Prunus Mahaleb L. Seed Extract on Ethylene glycol- and Ammonium Chloride-Induced Urolithiasis in BALB/c Mice

Iranian Journal of Medical Sciences
مقاله 8، دوره 45، شماره 2، خرداد 2020، صفحه 134-139    اصل مقاله (681.43 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijms.2019.45774
نویسندگان
Fatemeh Akbari1؛ Mohammad Azadbakht* 2؛ Ayat Dashti3؛ Lale Vahedi4؛ Ali Davoodi2
1Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
4Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Kidney stone disease can be quite painful, recurrent, and affects many people. Despite advances in drug therapy, there is still a need to find effective drugs with fewer complications for long-term treatment of kidney stones and to prevent its recurrence. The present study aimed to evaluate the effect of Prunus mahaleb L. seed extract on ethylene glycol- and ammonium chloride-induced urolithiasis in BALB/c mice.
Methods: The Prunus mahaleb L. seeds were collected in Mashhad (Iran) in June 2017. Urolithiasis was induced in male BALB/c mice by adding ethylene glycol (EG) 0.75% (v/v) and ammonium chloride (AC) 2% (w/v) to their drinking water for 21 consecutive days. A total of 72 animals were randomly divided into six groups of twelve animals each. Group 1 received purified water as control; group 2 received EG+AC in drinking water; groups 3-5 received the extracts by gavage in dosages of 100, 300, 500 mg/kg body weight, respectively; and group 6 received 888 mg/kg Sankol by gavage. Note that urolithiasis was induced in groups 3-6 in the same manner as in group 2. The data were analyzed using GraphPad Prism Software (version 5.01).
Results: The group receiving Prunus mahaleb L. extract in a 500 mg/kg dose responded better to the treatment and less damage to the kidney tissue was observed. The serum parameters remarkably decreased in the calculi-induced animals. Besides, the acute toxicity test showed that the use of the extract was safe in animals.
Conclusion: The results showed that the use of Prunus mahaleb L. extract effectively prevented the formation of kidney stones.
کلیدواژه‌ها
Prunus mahaleb L؛ Ethylene glycol؛ Ammonium chloride؛ Kidney calculi؛ Urolithiasis
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