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Nasimi, Maryam, Azizpour, Arghavan, Nikoo, Azita, Abedini, Robabeh, Shakoei, Safoura. (1398). Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report. سامانه مدیریت نشریات علمی, 44(6), 511-514. doi: 10.30476/ijms.2019.45771
Maryam Nasimi; Arghavan Azizpour; Azita Nikoo; Robabeh Abedini; Safoura Shakoei. "Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report". سامانه مدیریت نشریات علمی, 44, 6, 1398, 511-514. doi: 10.30476/ijms.2019.45771
Nasimi, Maryam, Azizpour, Arghavan, Nikoo, Azita, Abedini, Robabeh, Shakoei, Safoura. (1398). 'Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report', سامانه مدیریت نشریات علمی, 44(6), pp. 511-514. doi: 10.30476/ijms.2019.45771
Nasimi, Maryam, Azizpour, Arghavan, Nikoo, Azita, Abedini, Robabeh, Shakoei, Safoura. Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report. سامانه مدیریت نشریات علمی, 1398; 44(6): 511-514. doi: 10.30476/ijms.2019.45771

Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report

Iranian Journal of Medical Sciences
مقاله 9، دوره 44، شماره 6، بهمن 2019، صفحه 511-514    اصل مقاله (2.62 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.45771
نویسندگان
Maryam Nasimi1؛ Arghavan Azizpour1؛ Azita Nikoo2؛ Robabeh Abedini1؛ Safoura Shakoei* 3
1Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Bowen’s disease (BD) is a non-melanoma skin cancer with several histological subtypes. Herein we describe a case of a 35-year-old woman with a 4-cm diameter crusted plaque on the parietal scalp region. She had the lesion for 2 years. It had previously been histologically diagnosed as pemphigus vulgaris and only treated with a topical cream. The lesion progressively became thicker and larger. A new biopsy showed atypical cell proliferation through the whole thickness of the epidermis and follicular epithelium, with dermal microinvasion along with acantholysis and clear cell formation. The patient underwent total lesion excision (1 cm margin) with the diagnosis of both acantholytic and pagetoid subtypes of BD and dermal microinvasion. We describe a rare case of a young female patient with both subtypes of BD present in one lesion on an area not exposed to the sunlight. The lesion was initially misdiagnosed as pemphigus vulgaris.
کلیدواژه‌ها
Bowen’s disease؛ Pemphigus؛ Keratin-7؛ Skin neoplasms؛ Acantholysis
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