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Ebrahimnejad Gorji, K, Abedi Firouzjah, R, Khanzadeh, F, Abdi-Goushbolagh, N, Banaei, A, Ataei, Gh. (1398). Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software. سامانه مدیریت نشریات علمی, 9(3), 285-294. doi: 10.31661/jbpe.v0i0.984
K Ebrahimnejad Gorji; R Abedi Firouzjah; F Khanzadeh; N Abdi-Goushbolagh; A Banaei; Gh Ataei. "Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software". سامانه مدیریت نشریات علمی, 9, 3, 1398, 285-294. doi: 10.31661/jbpe.v0i0.984
Ebrahimnejad Gorji, K, Abedi Firouzjah, R, Khanzadeh, F, Abdi-Goushbolagh, N, Banaei, A, Ataei, Gh. (1398). 'Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software', سامانه مدیریت نشریات علمی, 9(3), pp. 285-294. doi: 10.31661/jbpe.v0i0.984
Ebrahimnejad Gorji, K, Abedi Firouzjah, R, Khanzadeh, F, Abdi-Goushbolagh, N, Banaei, A, Ataei, Gh. Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software. سامانه مدیریت نشریات علمی, 1398; 9(3): 285-294. doi: 10.31661/jbpe.v0i0.984

Estimating the Absorbed Dose of Organs in Pediatric Imaging of 99mTc-DTPA Radiopharmaceutical using MIRDOSE Software

Journal of Biomedical Physics and Engineering
مقاله 5، دوره 9، شماره 3، شهریور 2019، صفحه 285-294    اصل مقاله (627.2 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.984
نویسندگان
K Ebrahimnejad Gorji1؛ R Abedi Firouzjah2؛ F Khanzadeh2؛ N Abdi-Goushbolagh3؛ A Banaei4؛ Gh Ataei* 5
1Department of Medical Physics Radiobiology and Radiation Protection, Babol University of Medical Sciences, Babol, Iran
2Department of Medical Radiation, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5Department of Radiology Technology, Faculty of Paramedical Sciences, Babol University of Medical Science, Babol, Iran
چکیده
Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques.Material and Methods: In this applied research, fourteen children patients (6 males and 8 females) were imaged using a series of planar and SPECT images after injecting with technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA). A hybrid planar/SPECT method was used to plot time-activity curves to obtain the residence time of the source organs and also MIRDOSE software was used to calculate the absorbed dose of every organ. P-values were calculated using t-tests in order to make a comparison between the adsorbed doses of male and female groups..Results: Mean absorbed doses (µGy/MBq) for urinary bladder wall, kidneys, gonads, liver and adrenals were 213.5±47.8, 12.97±6.23, 12.0±2.5, 4.29±1.47, and 3.31±0.96, respectively. Furthermore, the mean effective dose was 17.5±3.7 µSv/MBq. There was not any significant difference in the mean absorbed dose of the two groups.Conclusion: Bladder cumulated activity was the most contribution in the effective dose of patients scanned with 99mTc-DTPA. Using a hybrid planar/SPECT method can cause an increase in accumulated activity accuracy for the region of interest. Moreover, patient-specified internal dosimetry is recommended.
کلیدواژه‌ها
Internal Dosimetry؛ Hybrid Planar/SPECT Method؛ MIRDOSE Software؛ 99mTc-DTPA
مراجع
  1. Sgouros G, Frey E, Wahl R, He B, Prideaux A, Hobbs R. Three-dimensional imaging-based radiobiological dosimetry. Semin Nucl Med. 2008;38:321-34. doi: 10.1053/j.semnuclmed.2008.05.008. PubMed PMID: 18662554; PubMed Central PMCID: PMC2597292.
  2. Zanzonico PB. Internal radionuclide radiation dosimetry: a review of basic concepts and recent developments. J Nucl Med. 2000;41:297-308. PubMed PMID: 10688115.
  3. Sgouros G, Frey EC, Bolch WE, Wayson MB, Abadia AF, Treves ST. An approach for balancing diagnostic image quality with cancer risk: application to pediatric diagnostic imaging of 99mTc-dimercaptosuccinic acid. J Nucl Med. 2011;52:1923-9. doi: 10.2967/jnumed.111.092221. PubMed PMID: 22144506; PubMed Central PMCID: PMC3290866.
  4. Parach AA, Rajabi H, Askari MA. Assessment of MIRD data for internal dosimetry using the GATE Monte Carlo code. Radiat Environ Biophys. 2011;50:441-50. doi: 10.1007/s00411-011-0370-0. PubMed PMID: 21573984.
  5. Prideaux AR, Song H, Hobbs RF, He B, Frey EC, Ladenson PW, et al. Three-dimensional radiobiologic dosimetry: Application of radiobiologic modeling to patient-specific 3-dimensional imaging–based internal dosimetry. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2007;48:1008.
  6. Momennezhad M, Nasseri S, Zakavi SR, Parach AA, Ghorbani M, Asl RG. A 3D Monte Carlo Method for Estimation of Patient-specific Internal Organs Absorbed Dose for (99m)Tc-hynic-Tyr(3)-octreotide Imaging. World J Nucl Med. 2016;15:114-23. doi: 10.4103/1450-1147.174700. PubMed PMID: 27134562; PubMed Central PMCID: PMC4809152.
  7. Goushbolagh NA, Farhood B, Astani A, Nikfarjam A, Kalantari M, Zare MH. Quantitative Cytotoxicity, Cellular Uptake and Radioprotection Effect of Cerium Oxide Nanoparticles in MRC-5 Normal Cells and MCF-7 Cancerous Cells. BioNanoScience. 2018:1-9.
  8. Stabin M. Nuclear medicine dosimetry. Phys Med Biol. 2006;51:R187-202. doi: 10.1088/0031-9155/51/13/R12. PubMed PMID: 16790903.
  9. Shahbazi-Gahrouei D, Nikzad S. Determination of organ doses in radioiodine therapy using medical internal radiation dosimetry (MIRD) method. Iran J Radiat Res. 2011;8:249-52.
  10. Chao TC, Xu XG. S-values calculated from a tomographic head/brain model for brain imaging. Phys Med Biol. 2004;49:4971-84.doi: 10.1088/0031-9155/49/21/009.PubMed PMID: 15584531.
  11. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023-7. PubMed PMID: 15937315.
  12. Bagheri M, Razavi-Ratki S, Nafisi-Moghadam R, Jelodari M, Parach A. The Estimation of 99mtc DMSA Absorbed Dose in Renal Scintigraphy of Pediatric Patients Using MIRDOSE Software and Planar/SPECT Hybrid Method. SSU_Journals. 2016;24:649-58.
  13. Domingues FC, Fujikawa GY, Decker H, Alonso G, Pereira JC, Duarte PS. Comparison of relative renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured with 99mTc-DMSA static scintigraphy. Int Braz J Urol. 2006;32:405-9.doi: 10.1590/s1677-55382006000400004.PubMed PMID: 16953906.
  14. Pirdamooie S, Shanei A, Moslehi M. Comparison of the absorbed dose for 99mTc-diethylenetriaminepentaacetic acid and 99mTc-ethylenedicysteine radiopharmaceuticals using medical internal radiation dosimetry. Journal of medical signals and sensors. 2015;5:171.doi: 10.4103/2228-7477.161489
  15. Siegel JA, Thomas SR, Stubbs JB, Stabin MG, Hays MT, Koral KF, et al. MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nucl Med. 1999;40:37S-61S. PubMed PMID: 10025848.
  16. Lyra M, Lagopati N, Charalambatou P, Vamvakas I. Patient-specific dosimetry in radionuclide therapy. Radiat Prot Dosimetry. 2011;147:258-63. doi: 10.1093/rpd/ncr329. PubMed PMID: 21831867.
  17. Zeintl J, Vija AH, Yahil A, Hornegger J, Kuwert T. Quantitative accuracy of clinical 99mTc SPECT/CT using ordered-subset expectation maximization with 3-dimensional resolution recovery, attenuation, and scatter correction. J Nucl Med. 2010;51:921.doi: 10.2967/jnumed.109.071571.
  18. Grimes J, Celler A, Birkenfeld B, Shcherbinin S, Listewnik MH, Piwowarska-Bilska H, et al. Patient-specific radiation dosimetry of 99mTc-HYNIC-Tyr3-octreotide in neuroendocrine tumors. J Nucl Med. 2011;52:1474-81. doi: 10.2967/jnumed.111.088203. PubMed PMID: 21795364.
  19. Grimes J, Celler A. Comparison of internal dose estimates obtained using organ-level, voxel S value, and Monte Carlo techniques. Med Phys. 2014;41:092501. doi: 10.1118/1.4892606. PubMed PMID: 25186410.
  20. Bolch WE, Eckerman KF, Sgouros G, Thomas SR. MIRD pamphlet No. 21: a generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature. J Nucl Med. 2009;50:477-84. doi: 10.2967/jnumed.108.056036. PubMed PMID: 19258258.
  21. Piepsz A, Ham HR. Pediatric applications of renal nuclear medicine. Semin Nucl Med. 2006;36:16-35. doi: 10.1053/j.semnuclmed.2005.08.002. PubMed PMID: 16356794.
  22. Dewaraja YK, Frey EC, Sgouros G, Brill AB, Roberson P, Zanzonico PB, et al. MIRD pamphlet no. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 2012;53:1310.doi: 10.2967/jnumed.111.100123.
  23. Bagheri M, Parach AA, Razavi-Ratki SK, Nafisi-Moghadam R, Jelodari MA. PATIENT-SPECIFIC DOSIMETRY FOR PEDIATRIC IMAGING OF 99mTc-DIMERCAPTOSUCCINIC ACID WITH GATE MONTE CARLO CODE. Radiat Prot Dosimetry. 2018;178:213-22. doi: 10.1093/rpd/ncx101. PubMed PMID: 28981712.
  24. Razaq T, Nisar H, Roohi S, Shehzad A, Ahmad I. Administration of 99mTc-DTPA in combination with doxorubicin alters the radiopharmaceutical biodistribution in rats. Iranian Journal of Nuclear Medicine. 2017;25:122-8.
  25. Stabin M, Taylor JA, Eshima D, Wooter W. Radiation dosimetry for technetium-99m-MAG3, technetium-99m-DTPA, and iodine-131-OIH based on human biodistribution studies. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1992;33:33-40.
  26. Lin KJ, Liu CY, Wey SP, Hsiao IT, Wu J, Fu YK, et al. Brain SPECT imaging and whole-body biodistribution with [(123)I]ADAM - a serotonin transporter radiotracer in healthy human subjects. Nucl Med Biol. 2006;33:193-202. doi: 10.1016/j.nucmedbio.2005.10.006. PubMed PMID: 16546673.
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