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Ghorbani, Zh, Fardid, R, Haddadi, G H, Derakhshanfar, A, Kouhpayeh, A, Haddadi, Z. (1398). Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats. سامانه مدیریت نشریات علمی, 10(1), 7-14. doi: 10.31661/jbpe.v0i0.832
Zh Ghorbani; R Fardid; G H Haddadi; A Derakhshanfar; A Kouhpayeh; Z Haddadi. "Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats". سامانه مدیریت نشریات علمی, 10, 1, 1398, 7-14. doi: 10.31661/jbpe.v0i0.832
Ghorbani, Zh, Fardid, R, Haddadi, G H, Derakhshanfar, A, Kouhpayeh, A, Haddadi, Z. (1398). 'Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats', سامانه مدیریت نشریات علمی, 10(1), pp. 7-14. doi: 10.31661/jbpe.v0i0.832
Ghorbani, Zh, Fardid, R, Haddadi, G H, Derakhshanfar, A, Kouhpayeh, A, Haddadi, Z. Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats. سامانه مدیریت نشریات علمی, 1398; 10(1): 7-14. doi: 10.31661/jbpe.v0i0.832

Histopathologic Evaluation of Radio-Protective Effect of Hesperidin on the Liver of Sprague Dawely Rats

Journal of Biomedical Physics and Engineering
مقاله 2، دوره 10، شماره 1، فروردین و اردیبهشت 2020، صفحه 7-14    اصل مقاله (1.4 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.832
نویسندگان
Zh Ghorbani1؛ R Fardid2، 3؛ G H Haddadi* 2، 3؛ A Derakhshanfar4؛ A Kouhpayeh5؛ Z Haddadi6
1MSc, Radiology Department, School of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
2PhD, Radiology Department, School of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
3PhD, Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), School of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
4PhD, Diagnostic Laboratory Sciences and Technology Research Center, Basic Sciences in Infection Diseases Research Center, Center of Comparative & Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5PhD, Department of Pharmacology, Fasa University of Medical Science, Fasa, Iran
6MD, Medical student, Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
چکیده
Background: Hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems.
Objective: In this article aims to investigate the radio-protective effect of hesperidin on the liver of Sprague Dawely rats.
Material and Methods: In this clinical study, 40 male rats were selected randomly and divided into 8 groups. Group 1 did not receive radiation and hesperidin (sham control). Group 2 received only 100 mg/kg body weight (b.w) of hesperidin for 7 consecutive days (HES group); group 3 exposed to dose of 2Gy whole body gamma radiation (2Gy group), and group 4 and 5 received 50 and 100 mg/kg b.w of HES for 7 consecutive days before 2 Gy gamma radiation, respectively.Group 6 exposed to dose of 8Gy gamma radiation (8Gy group); group 7 and 8 received 50 and 100 mg/kg b.w of HES for 7 days before 8Gy gamma irradiation, respectively. Histopathological evaluation was perfomred 24 hours after radiation.
Results: Administration of hesperidin (50 mg/kg b.w, 7 days) before 2Gy of gamma irradiation led to remove inflammatory mononuclear cells in the portal space. Microscopic findings in the groups receiving two doses of hesperidin (50 and 100 mg/kg b.w, orally, 7 days), before 8Gy of gamma radiation, were similar in a way that extreme dilation of central veins to be seen, however, there was no capillarization.
Conclusion: HES can be offered as a suitable radio-protector in radiotherapy patients and radiation workers.
کلیدواژه‌ها
Gamma Rays؛ Hesperidin؛ Radio-Protector؛ Hyperemia؛ Capillarization
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