Singh, N, Ahamed, S, Sinha, A, Srivastava, S, Painuly, N K, Mandal, A, Prasad, S N. (1399). Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector. سامانه مدیریت نشریات علمی, 10(2), 141-146. doi: 10.31661/jbpe.v0i0.1065
N Singh; S Ahamed; A Sinha; S Srivastava; N K Painuly; A Mandal; S N Prasad. "Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector". سامانه مدیریت نشریات علمی, 10, 2, 1399, 141-146. doi: 10.31661/jbpe.v0i0.1065
Singh, N, Ahamed, S, Sinha, A, Srivastava, S, Painuly, N K, Mandal, A, Prasad, S N. (1399). 'Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector', سامانه مدیریت نشریات علمی, 10(2), pp. 141-146. doi: 10.31661/jbpe.v0i0.1065
Singh, N, Ahamed, S, Sinha, A, Srivastava, S, Painuly, N K, Mandal, A, Prasad, S N. Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector. سامانه مدیریت نشریات علمی, 1399; 10(2): 141-146. doi: 10.31661/jbpe.v0i0.1065
Rectal and Bladder Dose Measurements in the Intracavitary Applications of Cervical Cancer Treatment with HDR Afterloading System: Comparison of TPS Data with MOSFET Detector
1PhD, Department of Radiotherapy, King George Medical University, Lucknow 226003, Uttar Pradesh, India
2MSc, Department of Radiation Physics, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, 500004, Telangana
3MSc, Department of Physics, Jawaharlal Nehru Technological University, Ananthapuramu, 515002, Andhra Pradesh
4PhD, Department of Radiotherapy, J.K.Cancer Institute, Kanpur 208002, Uttar Pradesh, India
5MSc, Department of Radiotherapy, King George Medical University, Lucknow 226003, Uttar Pradesh, India
6PhD, Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
7MD, Department of Radiotherapy, J.K.Cancer Institute, Kanpur 208002, Uttar Pradesh, India
چکیده
Background: Intracavitary brachytherapy plays a major role in management of cervical carcinoma. Assessment of dose received by OAR’s therefore becomes crucial for the estimation of radiation toxicities in HDR brachytherapy. Objective: Purpose of this study is to evaluate the role of in vivo dosimetry in HDR brachytherapy and to compare actual doses delivered to OAR’ s with those calculated during treatment planning. Material and Methods: In this retrospective study, 50 patients of cervical carcinoma were treated by Microselectron HDR. Out of 50 patients, 26 were treated with a dose of 7 Gy and 24 with a dose of 9 Gy, prescribed to point A. Brachytherapy planning and evaluation of dose to bladder and rectum was done on TPS & in vivo dosimetry was performed using portable MOSFET. Results: Calibration factors calculated for both dosimeters are almost equal and are 0.984 cGy/mV and 1.0895 cGy/mV. For bladder, dose deviation was found to be within ± 5% in 28 patients, ± 5-10% in 14 patients, ± 10-15% in 4 patients. Deviation between TPS-calculated dose and dose measured by MOSFET for rectum was within ± 5% in 31 patients, ± 5–10% in 8 patients, and ± 10–15% in 7 patients. Conclusion: TPS calculated doses were slightly higher than that measured by MOSFET. The use of small size MOSFET dosimeter is an efficient method for accurately measuring doses in high-dose gradient fields typically seen in brachytherapy. Therefore, to reduce the risk of large errors in dose delivery, in vivo dosimetry can be done in addition to TPS computations.
Perez CA, Camel HM, Kuske RR, Kao MS, Galakatos A, Hederman MA, et al. Radiation therapy alone in the treatment of carcinoma of the uterine cervix: a 20-year experience. Gynecol Oncol. 1986;23:127-40. doi: 10.1016/0090-8258(86)90216-7. PubMed PMID: 3943757.
Thompson S, Delaney G, Gabriel GS, Jacob S, Das P, Barton M. Estimation of the optimal brachytherapy utilization rate in the treatment of carcinoma of the uterine cervix: review of clinical practice guidelines and primary evidence. Cancer. 2006;107:2932-41. doi: 10.1002/cncr.22337. PubMed PMID: 17109449.
Chassagne D, Dutreix A, Almond P, Burgers J, Busch M, Joslin C. Dose and volume specification for reporting intracavitary therapy in gynaecology. ICRU Report 38; Bethesda: ICRU; 1985.
Haie-Meder C, Pötter R, Van Limbergen E, Briot E, De Brabandere M, Dimopoulos J, et al. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother Oncol. 2005;74:235-45. doi: 10.1016/j.radonc.2004.12.015.
Pötter R, Haie-Meder C, Van Limbergen E, Barillot I, De Brabandere M, Dimopoulos J, et al. Recommendations from gynaecological (GYN) GEC ESTRO working group (II): concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy—3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology. Radiother Oncol. 2006;78:67-77. doi: 10.1016/j.radonc.2005.11.014.
Kim RY, Shen S, Duan J. Image-based three-dimensional treatment planning of intracavitary brachytherapy for cancer of the cervix: dose-volume histograms of the bladder, rectum, sigmoid colon, and small bowel. Brachytherapy. 2007;6:187-94. doi: 10.1016/j.brachy.2006.11.005.
International Commission on Radiation Units and Measurements. ICRU report 58: Dose and volume specification for reporting interstitial therapy; Bethesda: ICRU; 1997.
Stuecklschweiger GF, Arian-Schad K, Poier E, Poschauko J, Hackl A. Bladder and rectal dose of gynecologic high-dose-rate implants: comparison of orthogonal radiographic measurements with in vivo and CT-assisted measurements. Radiology. 1991;181:889-94. doi: 10.1148/radiology.181.3.1947116.
Lahtinen T, Tenhunen M, Vayrynen M. ICRU reference points and maximum doses of rectum and bladder in intracavitary radiotherapy. Radiother Oncol. 1993;28:174-6. doi: 10.1016/0167-8140(93)90011-v. PubMed PMID: 8248560.
Clark BG, Souhami L, Roman TN, Evans MD, Pla C. Rectal complications in patients with carcinoma of the cervix treated with concomitant cisplatin and external beam irradiation with high dose rate brachytherapy: a dosimetric analysis. Int J Radiat Oncol Biol Phys. 1994;28:1243-50. doi: 10.1016/0360-3016(94)90501-0. PubMed PMID: 8175412.
Alecu R, Alecu M. In-vivo rectal dose measurements with diodes to avoid misadministrations during intracavitary high dose rate brachytherapy for carcinoma of the cervix. Med Phys. 1999;26:768-70. doi: 10.1118/1.598598. PubMed PMID: 10360540.
Waldhäusl C, Wambersie A, Pötter R, Georg D. In-vivo dosimetry for gynaecological brachytherapy: physical and clinical considerations. Radiother Oncol. 2005;77:310-7. doi: 10.1016/j.radonc.2005.09.004.
Sha RL, Reddy PY, Rao R, Muralidhar KR, Kudchadker RJ. Evaluation of rectal dose during high-dose-rate intracavitary brachytherapy for cervical carcinoma. Med Dosim. 2011;36:377-82. doi: 10.1016/j.meddos.2010.09.006. PubMed PMID: 21144733.
Sakata K, Nagakura H, Oouchi A, Someya M, Nakata K, Shido M, et al. High-dose-rate intracavitary brachytherapy: results of analyses of late rectal complications. Int J Radiat Oncol Biol Phys. 2002;54:1369-76. doi: 10.1016/s0360-3016(02)03055-9. PubMed PMID: 12459359.
Waldhäusl C, Wambersie A, Pötter R, Georg D. In-vivo dosimetry for gynaecological brachytherapy: physical and clinical considerations. Radiother Oncol. 2005;77:310-7. doi: 10.1016/j.radonc.2005.09.004.
Ramaseshan R, Kohli K, Zhang T, Lam T, Norlinger B, Hallil A, et al. Performance characteristics of a microMOSFET as an in vivo dosimeter in radiation therapy. Phys Med Biol. 2004;49:4031‑48.
