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The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial | ||
Iranian Journal of Immunology | ||
مقاله 4، دوره 16، شماره 3، آذر 2019، صفحه 225-234 اصل مقاله (530.34 K) | ||
نوع مقاله: Original Article | ||
شناسه دیجیتال (DOI): 10.22034/iji.2019.80273 | ||
نویسندگان | ||
Ayse Kilic* 1؛ Gulcin Otar Yener1؛ Aylin Yetim1؛ Mustafa Ozcetin1؛ Gulbin Gokcay2؛ Asuman Coban3؛ Zeynep Ince3؛ Beril Yasa3؛ Lutfiye Oksuz4؛ Funda Gungor Ugurlucan5؛ Nezahat Gurler4 | ||
1Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey | ||
2Istanbul University Institute of Child Health, Istanbul, Turkey | ||
3Department of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, Turkey | ||
4Department of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey | ||
5Department of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, Turkey | ||
چکیده | ||
Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. Results: The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. Conclusion: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. | ||
کلیدواژهها | ||
Infant؛ Maternal Immunization؛ Pertussis Vaccine | ||
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