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Kilic, Ayse, Yener, Gulcin Otar, Yetim, Aylin, Ozcetin, Mustafa, Gokcay, Gulbin, Coban, Asuman, Ince, Zeynep, Yasa, Beril, Oksuz, Lutfiye, Ugurlucan, Funda Gungor, Gurler, Nezahat. (1398). The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 16(3), 225-234. doi: 10.22034/iji.2019.80273
Ayse Kilic; Gulcin Otar Yener; Aylin Yetim; Mustafa Ozcetin; Gulbin Gokcay; Asuman Coban; Zeynep Ince; Beril Yasa; Lutfiye Oksuz; Funda Gungor Ugurlucan; Nezahat Gurler. "The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 16, 3, 1398, 225-234. doi: 10.22034/iji.2019.80273
Kilic, Ayse, Yener, Gulcin Otar, Yetim, Aylin, Ozcetin, Mustafa, Gokcay, Gulbin, Coban, Asuman, Ince, Zeynep, Yasa, Beril, Oksuz, Lutfiye, Ugurlucan, Funda Gungor, Gurler, Nezahat. (1398). 'The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 16(3), pp. 225-234. doi: 10.22034/iji.2019.80273
Kilic, Ayse, Yener, Gulcin Otar, Yetim, Aylin, Ozcetin, Mustafa, Gokcay, Gulbin, Coban, Asuman, Ince, Zeynep, Yasa, Beril, Oksuz, Lutfiye, Ugurlucan, Funda Gungor, Gurler, Nezahat. The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1398; 16(3): 225-234. doi: 10.22034/iji.2019.80273

The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial

Iranian Journal of Immunology
مقاله 4، دوره 16، شماره 3، آذر 2019، صفحه 225-234    اصل مقاله (530.34 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80273
نویسندگان
Ayse Kilic* 1؛ Gulcin Otar Yener1؛ Aylin Yetim1؛ Mustafa Ozcetin1؛ Gulbin Gokcay2؛ Asuman Coban3؛ Zeynep Ince3؛ Beril Yasa3؛ Lutfiye Oksuz4؛ Funda Gungor Ugurlucan5؛ Nezahat Gurler4
1Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey
2Istanbul University Institute of Child Health, Istanbul, Turkey
3Department of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, Turkey
4Department of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
5Department of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
چکیده
Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. Results: The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. Conclusion: Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months.
کلیدواژه‌ها
Infant؛ Maternal Immunization؛ Pertussis Vaccine
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