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Efficacy of Phenytoin Mucoadhesive Tablet versus Mouthwash on Chemotherapy-Induced Oral Mucositis: A Randomized Clinical Trial | ||
| Middle East Journal of Cancer | ||
| مقاله 9، دوره 10، شماره 4 - شماره پیاپی 40، دی 2019، صفحه 341-349 اصل مقاله (1.05 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2019.78656. | ||
| نویسندگان | ||
| Fahimeh Rezazadeh1؛ Soleiman Mohammadi-Samani2؛ Fatemeh Talei3؛ Mani Ramzi4؛ Hajar Ashrafi5؛ Zahra Emami* 6 | ||
| 1Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Pharmaceutics and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Students’ Research Committee, School of Dentistry, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Hematology Research Center, Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Department of Periodontology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Oral mucositis is one of the painful, debilitating and common complications in the patients under chemotherapy for which no certain and effective treatment has not been considered. The aim of this pilot study was to evaluate the efficacy of phenytoin mucoadhesive tablets on treating oral mucositis compared with phenytoin mouthwash. Methods: In this clinical trial, after preparation and in vitro characterization of phenytoin mucoadhesive tablets, 27 patients were enrolled from oncology department of Nemazee Hospital, Shiraz, Iran. 21 patients with oral mucositis, who had the inclusion criteria due to chemotherapy, were divided into two groups of A (11 patients received phenytoin mouthwash 0.5%) and B (10 patients received phenytoin mucoadhesive tablet). Severity of oral mucositis (WHO grading), oral pain Visual Analogue Scale and the extension of lesions (number of involved sites) were assessed on three intervals (at the beginning and one or two weeks after beginning of the study). Results: In the first visit, there was no significant statistical difference between the two groups regarding mean age, mucositis severity and visual analogue scale. However, on first and second weeks after beginning of the study, mucositis severity, extension of lesion and visual analogue scale in both groups were significantly lower than onset of the treatment; however, no significant difference between the two groups was observed. Conclusions: Phenytoin mouthwash and mucoadhesive tablets used for oral mucositis care in patients after chemotherapy showed significant improvement in the lesions. Patients were more satisfied with mouthwash and all the patients in this group were free of lesion after two weeks. | ||
| کلیدواژه‌ها | ||
| Mucositis؛ Phenytoin؛ Mucoadhesive؛ Mouthwash | ||
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آمار تعداد مشاهده مقاله: 3,537 تعداد دریافت فایل اصل مقاله: 1,864 |
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