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Omidvari, Shapour, Hasan, Sayed, Razzaghi, Samira, Nasrolahi, Hamid, Mosalaei, Ahmad, Ahmadloo, Niloofar, Ansari, Mansour. (1392). Malignant Neoplasms of the Anal Canal. سامانه مدیریت نشریات علمی, 1(2), 4-5. doi: 10.17795/acr-11985
Shapour Omidvari; Sayed Hasan; Samira Razzaghi; Hamid Nasrolahi; Ahmad Mosalaei; Niloofar Ahmadloo; Mansour Ansari. "Malignant Neoplasms of the Anal Canal". سامانه مدیریت نشریات علمی, 1, 2, 1392, 4-5. doi: 10.17795/acr-11985
Omidvari, Shapour, Hasan, Sayed, Razzaghi, Samira, Nasrolahi, Hamid, Mosalaei, Ahmad, Ahmadloo, Niloofar, Ansari, Mansour. (1392). 'Malignant Neoplasms of the Anal Canal', سامانه مدیریت نشریات علمی, 1(2), pp. 4-5. doi: 10.17795/acr-11985
Omidvari, Shapour, Hasan, Sayed, Razzaghi, Samira, Nasrolahi, Hamid, Mosalaei, Ahmad, Ahmadloo, Niloofar, Ansari, Mansour. Malignant Neoplasms of the Anal Canal. سامانه مدیریت نشریات علمی, 1392; 1(2): 4-5. doi: 10.17795/acr-11985

Malignant Neoplasms of the Anal Canal

Iranian Journal of Colorectal Research
مقاله 4، دوره 1، شماره 2، آذر 2013، صفحه 4-5    اصل مقاله (408.65 K)
شناسه دیجیتال (DOI): 10.17795/acr-11985
نویسندگان
Shapour Omidvari1؛ Sayed Hasan* ؛ Samira Razzaghi2؛ Hamid Nasrolahi1؛ Ahmad Mosalaei3؛ Niloofar Ahmadloo1؛ Mansour Ansari1
1Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
2Student Research Committee, Resident of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
3Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, IR Iran
چکیده
Background Malignant neoplasms of the anal canal are rare, accounting for approximately 4% of all colorectal malignancies. Objectives The present study aimed to report the clinicopathological characteristics and treatment outcomes of 41 cases with malignant neoplasms of the anal canal. Patients and Methods Between 1999 and 2012, 41 consecutive patients were diagnosed with primary malignant neoplasm of the anal canal, who were treated and followed up at Namazi hospital. Only primary malignant tumors arising from the anal canal were included. Patients with secondary anal canal involvement from rectal or perianal skin cancers and metastatic tumors were excluded. Results There were 22 women and 19 men, aged 33 to 83 years, with a median age of 57 years at diagnosis. Sixteen patients (39%) had localized disease, 21 (51%) had regional disease, and 4 (10%) had metastatic disease at diagnosis. Squamous cell carcinoma (61%) was the most frequent histologic subtype, followed by adenocarcinoma (27%), malignant melanoma (10%), and gastrointestinal stromal tumor (2%). After a median follow-up of 51 (11-169) months for surviving patients, 22 patients were alive and without disease, three were alive with disease, and 19 patients died due to the disease. Histological subtype (P = 001), and stage of disease (P = 0.002) were prognostic factors for overall survival. The 5-year local control, disease-free, and overall survival rates for all patients were 63.9%, 53%, and 59.4% respectively. Conclusions This study indicated that squamous cell carcinoma, adenocarcinoma, and malignant melanoma are the most frequent malignant neoplasms in the anal canal. Histological subtype and disease stage are the most important prognostic factors for overall survival in this region.
کلیدواژه‌ها
Malignant Neoplasms؛ Anal canal Carcinoma Squamous Cell؛ Adenocarcinoma؛ Melanoma؛ Gastrointestinal Stromal Tumor
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