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Karimian, Ava, Sadeghpour, Hossein, Khademian, Sedigheh, Zarshenas, Mohammad M.. (1398). A Gas Chromatographic-Based Method for Determination of γ- terpinene in a herbal solid dosage form. سامانه مدیریت نشریات علمی, 5(2), 103-110. doi: 10.30476/tips.2019.83049.1021
Ava Karimian; Hossein Sadeghpour; Sedigheh Khademian; Mohammad M. Zarshenas. "A Gas Chromatographic-Based Method for Determination of γ- terpinene in a herbal solid dosage form". سامانه مدیریت نشریات علمی, 5, 2, 1398, 103-110. doi: 10.30476/tips.2019.83049.1021
Karimian, Ava, Sadeghpour, Hossein, Khademian, Sedigheh, Zarshenas, Mohammad M.. (1398). 'A Gas Chromatographic-Based Method for Determination of γ- terpinene in a herbal solid dosage form', سامانه مدیریت نشریات علمی, 5(2), pp. 103-110. doi: 10.30476/tips.2019.83049.1021
Karimian, Ava, Sadeghpour, Hossein, Khademian, Sedigheh, Zarshenas, Mohammad M.. A Gas Chromatographic-Based Method for Determination of γ- terpinene in a herbal solid dosage form. سامانه مدیریت نشریات علمی, 1398; 5(2): 103-110. doi: 10.30476/tips.2019.83049.1021

A Gas Chromatographic-Based Method for Determination of γ- terpinene in a herbal solid dosage form

Trends in Pharmaceutical Sciences
مقاله 5، دوره 5، شماره 2، شهریور 2019، صفحه 103-110    اصل مقاله (622.31 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2019.83049.1021
نویسندگان
Ava Karimian1؛ Hossein Sadeghpour2؛ Sedigheh Khademian3؛ Mohammad M. Zarshenas* 1، 4
1Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
As a physiologic process, reflux commonly occurred following a daily meal with no sign. Heartburn in Traditional Persian Medicine (TPM) has been defined as “Harghat-e-me’adeh” or “Josha-e-hāmez”. Regarding the clinical importance of this complication, in current work a related traditional formulation containing True cardamom, Ginger, Black cumin and Mastic, selected from various related traditional formulations which have been extracted from three main Qarabadin textbooks of Persian medicine. Following content authentication and microscopic characterization, various tablet formulations were prepared using excipients. The final formulation was a tablet containing those ingredients in 28% for each, with avicel (9/8%) and Magnesium stearate (0.2%) as a binder, respectively. Chemical composition analysis was carried out using Gas Chromatography/ Mass spectrometry apparatus (GC/MS). α-terpinyl acetate (34.02%), 1,8- cineole (18.07), cumin-aldehyde (8.15), and γ-terpinene (11.74%) were identified as major constituents. The content determination of the tablet was performed via Gas Chromatography/ Flame ionization detector (GC/FID). The fingerprint obtained from IR Spectroscopy. Data on pharmaceutical assessment were included friability (less than 1%), weight variation (less than 1%), hardness (6.5±0.5 kg/cm2), disintegration time (less than 35 min) and thickness (3.02±.04 mm). The yield of essential oil extracted from the tablet was found 3%, and each tablet contained 1.33 mg γ-terpinene. This finished product can be introduced as medicine for clinical trial and pharmaceutical industry.
کلیدواژه‌ها
Gas chromatography؛ Formulation؛ Tablet؛ Quantification
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