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Shahriari, Sahar, Eftekhari, Mohammad Hasan, Jeddi, Marjan. (1397). The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia. سامانه مدیریت نشریات علمی, 3(4), 185-191. doi: 10.30476/ijns.2019.82643.1021
Sahar Shahriari; Mohammad Hasan Eftekhari; Marjan Jeddi. "The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia". سامانه مدیریت نشریات علمی, 3, 4, 1397, 185-191. doi: 10.30476/ijns.2019.82643.1021
Shahriari, Sahar, Eftekhari, Mohammad Hasan, Jeddi, Marjan. (1397). 'The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia', سامانه مدیریت نشریات علمی, 3(4), pp. 185-191. doi: 10.30476/ijns.2019.82643.1021
Shahriari, Sahar, Eftekhari, Mohammad Hasan, Jeddi, Marjan. The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia. سامانه مدیریت نشریات علمی, 1397; 3(4): 185-191. doi: 10.30476/ijns.2019.82643.1021

The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia

International Journal of Nutrition Sciences
مقاله 3، دوره 3، شماره 4، اسفند 2018، صفحه 185-191    اصل مقاله (527.34 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2019.82643.1021
نویسندگان
Sahar Shahriari1؛ Mohammad Hasan Eftekhari* 2؛ Marjan Jeddi3
1Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
3Internal Medicine Department, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Vitamin D supplementation was shown to reduce obesityrelated oxidative stress and inflammation among overweight or obese people as well as improving glycemic control and lipid profile in type 2 diabetic (T2D) patients. This study was conducted to determine the effect of vitamin D supplementation on metabolic biomarkers, oxidative stress and systemic inflammation in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia.
Methods: In this randomized, double-blind placebo-controlled clinical trial, 60 individuals with T2D, vitamin D deficiency and BMI greater than 25 kg/m2 were randomly divided in two groups to receive either vitamin D (50000 IU, once a week) or placebo (1000 mg corn oil, once
a week) for eight weeks. At the entry and end of study, blood samples were collected to evaluate serum high sensitive C-reactive protein (hs-CRP), fasting blood sugar (FBS), glycated hemoglobin (HbA1c) malondialdehyde (MDA), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG).
Results: At the end of the study, serum FBS (P=0.04), TG (P=0.02) and hs-CRP (P=0.02) levels significantly decreased in the vitamin D supplemented group in comparison to the control group. Supplementation with vitamin D was associated with significant improvements in serum 25 –OH vitamin D levels when compared to the control group.
Conclusion: This study indicates that eight weeks supplementation of vitamin D may improve lipid, glycemic and inflammatory indices in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia.
کلیدواژه‌ها
Vitamin D؛ Diabetes mellitus؛ Dyslipidemia؛ Obesity؛ Inflammation
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