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Abolhasanpour, Nasrin, Hajebrahimi, Sakineh, Ebrahimi-Kalan, Abbas, Mehdipour, Ahmad, Salehi-Pourmehr, Hanieh. (1398). Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review. سامانه مدیریت نشریات علمی, 45(1), 2-15. doi: 10.30476/ijms.2019.45318
Nasrin Abolhasanpour; Sakineh Hajebrahimi; Abbas Ebrahimi-Kalan; Ahmad Mehdipour; Hanieh Salehi-Pourmehr. "Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review". سامانه مدیریت نشریات علمی, 45, 1, 1398, 2-15. doi: 10.30476/ijms.2019.45318
Abolhasanpour, Nasrin, Hajebrahimi, Sakineh, Ebrahimi-Kalan, Abbas, Mehdipour, Ahmad, Salehi-Pourmehr, Hanieh. (1398). 'Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review', سامانه مدیریت نشریات علمی, 45(1), pp. 2-15. doi: 10.30476/ijms.2019.45318
Abolhasanpour, Nasrin, Hajebrahimi, Sakineh, Ebrahimi-Kalan, Abbas, Mehdipour, Ahmad, Salehi-Pourmehr, Hanieh. Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review. سامانه مدیریت نشریات علمی, 1398; 45(1): 2-15. doi: 10.30476/ijms.2019.45318

Urodynamic Parameters in Spinal Cord Injury-Induced Neurogenic Bladder Rats after Stem Cell Transplantation: A Narrative Review

Iranian Journal of Medical Sciences
مقاله 2، دوره 45، شماره 1، فروردین 2020، صفحه 2-15    اصل مقاله (302.35 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2019.45318
نویسندگان
Nasrin Abolhasanpour1؛ Sakineh Hajebrahimi2؛ Abbas Ebrahimi-Kalan3؛ Ahmad Mehdipour4؛ Hanieh Salehi-Pourmehr* 5
1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Research Center for Evidence Based-Medicine, Iranian EBM Centre: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Urology, Imam Reza Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Ira
3Department of Neurosciences and Cognitive, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Tissue Engineering, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
5Research Center for Evidence Based-Medicine, Iranian EBM Centre: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran; Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Neurogenic bladder (NGB) secondary to spinal cord injury (SCI) is accompanied with several complications such as urinary tract deterioration, urinary incontinence, and consequently lower quality of life (QoL), significant morbidities, and occasionally death. Current therapeutic methods have some side effects and there is no treatment for the upper urinary tract injuries. Stem cell therapy is a promising method for treating this condition. However, the best timing and the best route of its transplantation have not yet been determined. Animal models of SCI, especially in rats, are the most commonly used method for evaluating the efficacy of cell therapy in NGB improvement, and the most common assessment method is the urodynamic studies (UDS). However, there are variations in the range of UDS parameters among the published studies. The current review aimed to discuss the effect of stem cell transplantation on bladder dysfunction recovery based on urodynamic parameters after SCI in rats. For this purpose, the cell source, doses, the route of administration, and the complete UDS equipment and its parameters were summarized in SCI models in rats. In some urodynamic test results, to some extent, an improvement in the lower urinary system function was observed in each treatment group. However, this improvement was far from full functional recovery. The average cell dose was about 1 million cells in every injected site. In most studies, the stem cells (SCs) were transplanted 9 days after the injury using PE-50 and PE-60. Many researchers have recommended further experimental and clinical studies to confirm this treatment modality.
کلیدواژه‌ها
Urodynamic؛ Spinal cord injuries؛ Urinary bladder؛ Neurogenic؛ Stem cell transplantation
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