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Khalili, Azadeh, Alipour, Shohreh, Fathalipour, Mohammad, Purkhosrow, Azar, Mashghoolozekr, Elaheh, Bayat, Gholamreza, Nekooeian, Ali Akbar. (1398). Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats. سامانه مدیریت نشریات علمی, 45(1), 41-49. doi: 10.30476/ijms.2019.45310
Azadeh Khalili; Shohreh Alipour; Mohammad Fathalipour; Azar Purkhosrow; Elaheh Mashghoolozekr; Gholamreza Bayat; Ali Akbar Nekooeian. "Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats". سامانه مدیریت نشریات علمی, 45, 1, 1398, 41-49. doi: 10.30476/ijms.2019.45310
Khalili, Azadeh, Alipour, Shohreh, Fathalipour, Mohammad, Purkhosrow, Azar, Mashghoolozekr, Elaheh, Bayat, Gholamreza, Nekooeian, Ali Akbar. (1398). 'Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats', سامانه مدیریت نشریات علمی, 45(1), pp. 41-49. doi: 10.30476/ijms.2019.45310
Khalili, Azadeh, Alipour, Shohreh, Fathalipour, Mohammad, Purkhosrow, Azar, Mashghoolozekr, Elaheh, Bayat, Gholamreza, Nekooeian, Ali Akbar. Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats. سامانه مدیریت نشریات علمی, 1398; 45(1): 41-49. doi: 10.30476/ijms.2019.45310

Liposomal and Non-Liposomal Formulations of Vitamin C: Comparison of the Antihypertensive and Vascular Modifying Activity in Renovascular Hypertensive Rats

Iranian Journal of Medical Sciences
مقاله 6، دوره 45، شماره 1، فروردین 2020، صفحه 41-49    اصل مقاله (814.96 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.45310
نویسندگان
Azadeh Khalili1؛ Shohreh Alipour2؛ Mohammad Fathalipour3؛ Azar Purkhosrow3؛ Elaheh Mashghoolozekr4؛ Gholamreza Bayat5؛ Ali Akbar Nekooeian* 6
1Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
2Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
4Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Physiology and Pharmacology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
6Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, and Cardiovascular Pharmacology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs’ effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid.
Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypertensive (HTN), vehicle-receiving hypertensive (HTN-Veh), two liposomal Ascorbic acid-treated hypertensive at 50 or 100 mg/kg/day (LVC-50 and LVC-100), and two non-liposomal Ascorbic acid-treated hypertensive at 50 or 100 mg/kg/day (VC-50 and VC-100). Systolic blood pressure (SBP) and heart rate (HR) were measured weekly; after 4 weeks, dose-responses to phenylephrine (PE) in the absence and presence of nitro-L-arginine methyl ester (L-NAME), acetylcholine (Ach), and sodium nitroprusside (SNP) were obtained on aortic rings. Data were analyzed with one-way ANOVA and Duncan’s multiple range test at a P value of Results: Compared to the non-liposomal form, the liposomal one was associated with more prominent effects on the final SBP. Both forms of Ascorbic acid decreased SBP dose-dependently. The basal and stimulated release of Nitric Oxide (NO) was significantly recovered by both forms of Ascorbic acid. The PE maximal responses were not significantly different between the liposomal and non-liposomal groups (P=0.08). Although the Emax of Ach-relaxation response was not different in two preparation forms, Ach-relaxation response induced a lower concentration of the liposomal form of Ascorbic acid (P=0.03)
Conclusion: The liposomal Ascorbic acid exhibited relaxation activity in significantly lower concentrations. The observed effects were partly mediated by the increased basal release of NO.
کلیدواژه‌ها
Liposomes؛ Ascorbic acid؛ Rats؛ Hypertension؛ Nitric oxide
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مراجع
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