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Pakfetrat, Maryam, Sharifpour, Shokouh, Malekmakan, Leila, Ezzatzadegan Jahromi, Shahrokh, Roozbeh, Jamshid, Aslani, Amir. (1393). The Effect of Magnesium Oxide on Hyperphosphatemia in Female Hemodialysis Patients. سامانه مدیریت نشریات علمی, 1(2), 1-5. doi: 10.17795/whb-20048
Maryam Pakfetrat; Shokouh Sharifpour; Leila Malekmakan; Shahrokh Ezzatzadegan Jahromi; Jamshid Roozbeh; Amir Aslani. "The Effect of Magnesium Oxide on Hyperphosphatemia in Female Hemodialysis Patients". سامانه مدیریت نشریات علمی, 1, 2, 1393, 1-5. doi: 10.17795/whb-20048
Pakfetrat, Maryam, Sharifpour, Shokouh, Malekmakan, Leila, Ezzatzadegan Jahromi, Shahrokh, Roozbeh, Jamshid, Aslani, Amir. (1393). 'The Effect of Magnesium Oxide on Hyperphosphatemia in Female Hemodialysis Patients', سامانه مدیریت نشریات علمی, 1(2), pp. 1-5. doi: 10.17795/whb-20048
Pakfetrat, Maryam, Sharifpour, Shokouh, Malekmakan, Leila, Ezzatzadegan Jahromi, Shahrokh, Roozbeh, Jamshid, Aslani, Amir. The Effect of Magnesium Oxide on Hyperphosphatemia in Female Hemodialysis Patients. سامانه مدیریت نشریات علمی, 1393; 1(2): 1-5. doi: 10.17795/whb-20048

The Effect of Magnesium Oxide on Hyperphosphatemia in Female Hemodialysis Patients

Women’s Health Bulletin
مقاله 6، دوره 1، شماره 2، مهر 2014، صفحه 1-5    اصل مقاله (155.15 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.17795/whb-20048
نویسندگان
Maryam Pakfetrat1؛ Shokouh Sharifpour2؛ Leila Malekmakan* 3؛ Shahrokh Ezzatzadegan Jahromi1؛ Jamshid Roozbeh1؛ Amir Aslani4
1Department of Internal Medicine, Shiraz Nephro Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
2Shiraz Nephro Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3Department of Community Medicine, Shiraz Nephro Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4Department of Cardiology, Shiraz University of Medical Sciences, Shiraz, IR Iran
چکیده
Background: Hyperphosphatemia is a common problem in hemodialysis patients for which various binders are used to control this problem.
Objectives: This study aims to assess the effect of magnesium oxide on controlling serum phosphorus levels and evaluate its side effects.
Patients and Methods: We studied 39 hemodialysis patients with hyperphosphatemia. Patients were randomly divided into two groups, trial and control. The trial group received magnesium oxide. Its dose was titrated according to weekly magnesium levels that were checked for 4 weeks. Phosphorous was also checked weekly in both groups. Data were analyzed by SPSS 15 software. P-values less than 0.05 were considered significant.
Results: A total of 27 males and 12 females with a mean age 54.01 ± 17.20 years were divided into the trial (21 patients) and control (18 patients) groups. Serum phosphorous levels did not significantly decrease (P = 0.994). However the mean phosphorous level in females showed significant correlation with time, as a significant quadratic trend throughout time was observed (P = 0.001). A significant ascending trend in mean magnesium levels was observed in the trial group compared to the control group at the end of the study (P < 0.001).
Conclusions: Although magnesium oxide was well tolerated by the study patients and lacked serious complications, it could not decrease phosphorous levels. In order to better assess these results we recommend that larger, multicenter studies with longer follow up that uses other magnesium compounds be designed.
کلیدواژه‌ها
Hemodialysis؛ Hyperphosphatemia؛ Phosphorus؛ Magnesium Oxide
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