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Mozafari, Negin, Azadi, Soha, Mohammadi Samani, Soliman, Farjadian, Fatemeh, Azadi, Amir. (1397). Concurrent analysis of Simvastatin and citicoline using a Reversed-phase High Performance Liquid Chromatography-Ultra Violet Method. سامانه مدیریت نشریات علمی, 5(1), 41-46. doi: 10.30476/tips.2019.81749.1006
Negin Mozafari; Soha Azadi; Soliman Mohammadi Samani; Fatemeh Farjadian; Amir Azadi. "Concurrent analysis of Simvastatin and citicoline using a Reversed-phase High Performance Liquid Chromatography-Ultra Violet Method". سامانه مدیریت نشریات علمی, 5, 1, 1397, 41-46. doi: 10.30476/tips.2019.81749.1006
Mozafari, Negin, Azadi, Soha, Mohammadi Samani, Soliman, Farjadian, Fatemeh, Azadi, Amir. (1397). 'Concurrent analysis of Simvastatin and citicoline using a Reversed-phase High Performance Liquid Chromatography-Ultra Violet Method', سامانه مدیریت نشریات علمی, 5(1), pp. 41-46. doi: 10.30476/tips.2019.81749.1006
Mozafari, Negin, Azadi, Soha, Mohammadi Samani, Soliman, Farjadian, Fatemeh, Azadi, Amir. Concurrent analysis of Simvastatin and citicoline using a Reversed-phase High Performance Liquid Chromatography-Ultra Violet Method. سامانه مدیریت نشریات علمی, 1397; 5(1): 41-46. doi: 10.30476/tips.2019.81749.1006

Concurrent analysis of Simvastatin and citicoline using a Reversed-phase High Performance Liquid Chromatography-Ultra Violet Method

Trends in Pharmaceutical Sciences
مقاله 3، دوره 5، شماره 1، خرداد 2019، صفحه 41-46    اصل مقاله (425.62 K)
نوع مقاله: Research(Original) Article
شناسه دیجیتال (DOI): 10.30476/tips.2019.81749.1006
نویسندگان
Negin Mozafari1؛ Soha Azadi2؛ Soliman Mohammadi Samani1؛ Fatemeh Farjadian3؛ Amir Azadi* 1
1Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
To develop and evaluate a sensitive, accurate, rapid and reproducible high performance liquid chromatography analytical method for concurrent assay of simvastatin, a hyperlipidemia controlling agent, and citicoline, a psychostimulant agent, a C18 column (Eurosphar 100-5, 150 mm × 4.6 mm) used as a reversed stationary phase and mobile phase was water (previously adjusted with phosphoric acid to a pH of 5.5), methanol and acetonitrile (20:20:60) with the flow rate 1.0 ml/min. The ultraviolet detector was set at 247 nm. A linear correlation between each concentration and its own AUC within concentration ranges of 15 to 100 g/ml for citicoline and 7.5 to 50 g/ml for simvastatin with a correlation coefficient 0.9969 for citicoline and 0.994 for simvastatin were produced. The within and between-day precision and accuracy were both in acceptable ranges. The outcomes of these tests show an accurate, rapid and robust HPLC-UV method for successful analysis of both simvastatin and citicoline simultaneously.
کلیدواژه‌ها
Citicoline؛ Simvastatin؛ HPLC
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