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Mohammadi, Mehrdad, Nouri-Mahdavi, Kia, Barzegar, Abbas. (1398). Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial. سامانه مدیریت نشریات علمی, 44(6), 457-464. doi: 10.30476/ijms.2019.44969
Mehrdad Mohammadi; Kia Nouri-Mahdavi; Abbas Barzegar. "Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial". سامانه مدیریت نشریات علمی, 44, 6, 1398, 457-464. doi: 10.30476/ijms.2019.44969
Mohammadi, Mehrdad, Nouri-Mahdavi, Kia, Barzegar, Abbas. (1398). 'Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial', سامانه مدیریت نشریات علمی, 44(6), pp. 457-464. doi: 10.30476/ijms.2019.44969
Mohammadi, Mehrdad, Nouri-Mahdavi, Kia, Barzegar, Abbas. Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial. سامانه مدیریت نشریات علمی, 1398; 44(6): 457-464. doi: 10.30476/ijms.2019.44969

Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial

Iranian Journal of Medical Sciences
مقاله 3، دوره 44، شماره 6، بهمن 2019، صفحه 457-464    اصل مقاله (599.17 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44969
نویسندگان
Mehrdad Mohammadi؛ Kia Nouri-Mahdavi* ؛ Abbas Barzegar
Isfahan Kidney Transplantation Research Center, Department of Urology, Alzahra Research Centers, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: The incidence of renal hemorrhage during percutaneous nephrolithotomy (PCNL) is high. We sought to evaluate the effects of tranexamic acid (TXA) on bleeding and hemoglobin levels of patients with staghorn calculi treated with PCNL.
Methods: In a double-blind clinical trial, 120 patients with staghorn calculi candidated for PCNL in Alzahra Hospital between January 2014 and November 2017, Isfahan, Iran, were classified into two groups in terms of the stone size (>4 cm and Results: The mean volume of blood loss was significantly higher in the control group patients than in those receiving TXA, in both stone-size categories (P<0.001). There was no significant difference in the postoperative hemoglobin level between the intervention and control groups, in both stone-size categories (P=0.26 and P=0.10, respectively). In addition, the mean volume of blood loss increased significantly with an increase in the operative duration (P<0.001).
Conclusion: TXA reduced the risk of bleeding during and after PCNL and attenuated the drop in the hemoglobin level in the postoperative period. Longer operative procedures were associated with an increase in the bleeding volume.
Trial Registration Number: IRCT20180209038673N1
کلیدواژه‌ها
Tranexamic acid؛ Staghorn calculus؛ Bleeding؛ Hemoglobin
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