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Firoozi, Donya, Nekooeian, Ali Akbar, Tanideh, Nader, Mazloom, Zohreh, Mokhtari, Maral, Mohammadi Sartang, Mohsen. (1398). The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats. سامانه مدیریت نشریات علمی, 44(6), 501-510. doi: 10.30476/ijms.2019.44961
Donya Firoozi; Ali Akbar Nekooeian; Nader Tanideh; Zohreh Mazloom; Maral Mokhtari; Mohsen Mohammadi Sartang. "The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats". سامانه مدیریت نشریات علمی, 44, 6, 1398, 501-510. doi: 10.30476/ijms.2019.44961
Firoozi, Donya, Nekooeian, Ali Akbar, Tanideh, Nader, Mazloom, Zohreh, Mokhtari, Maral, Mohammadi Sartang, Mohsen. (1398). 'The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats', سامانه مدیریت نشریات علمی, 44(6), pp. 501-510. doi: 10.30476/ijms.2019.44961
Firoozi, Donya, Nekooeian, Ali Akbar, Tanideh, Nader, Mazloom, Zohreh, Mokhtari, Maral, Mohammadi Sartang, Mohsen. The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats. سامانه مدیریت نشریات علمی, 1398; 44(6): 501-510. doi: 10.30476/ijms.2019.44961

The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats

Iranian Journal of Medical Sciences
مقاله 8، دوره 44، شماره 6، بهمن 2019، صفحه 501-510    اصل مقاله (3.27 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44961
نویسندگان
Donya Firoozi1؛ Ali Akbar Nekooeian2؛ Nader Tanideh2؛ Zohreh Mazloom* 3؛ Maral Mokhtari4؛ Mohsen Mohammadi Sartang5
1Department of Nutrition and Diet Therapy, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Clinical Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran;
4Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Ulcerative colitis is an inflammatory disease with indefinite treatment. The present study aimed to assess the anti-inflammatory and antioxidant effects of Carum copticum L. (CC) extract on induced colitis in rats.
Methods: Sixty male rats were randomly divided into six groups (n=10 per group). Acetic acid-induced colitis rats were orally administered with doses of 100, 200, and 400 mg/kg CC extract, and 100 mg/kg sulfasalazine for seven consecutive days, respectively. Colonic biopsies were taken to measure histopathological parameters as well as the tumor necrosis factor (TNF-α), interleukin-6 (IL-6), myeloperoxidase (MPO), malondialdehyde (MDA), and glutathione (GSH). Data analysis was performed using the one-way ANOVA and Tukey’s test for normally distributed data. Kruskal-Wallis test followed by Dunn’s test was used for non-normally distributed data. The analysis was performed at P≤0.05 using SigmaStat software (version 10.0).
Results: The control colitis group had a significantly higher total colitis index (P=0.01), TNF-α (P=0.01), IL-6 (P=0.01), MPO (P=0.01), and MDA (P=0.01); and lower GSH (P=0.01) than those of the sham group. The colitis group receiving a dose of 200 mg/kg/day CC extract had a significantly lower total colitis index (P=0.01), TNF-α (P=0.01), IL-6 (P=0.01), MPO (P=0.01), and MDA (P=0.01); and higher GSH (P=0.01) than those of the control colitis group. The colitis group receiving a dose of 200 mg/kg/day CC extract had a significantly lower total colitis index (P=0.04), TNF-α (P=0.03), IL-6 (P=0.04), MPO (P=0.03), and MDA (P=0.03); and higher GSH (P=0.01) than those of the colitis group receiving sulfasalazine.
Conclusion: The present study revealed that CC extract had healing effects on colitis, possibly due to its antioxidant and anti-inflammatory properties.
کلیدواژه‌ها
Colitis؛ Ulcerative؛ Rats؛ Cytokines؛ Antioxidants؛ Anti-Inflammatory agents
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