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An Experimental Study on Spinal Cord µ-Opioid and α2-Adrenergic Receptors mRNA Expression Following Stress-Induced Hyperalgesia in Male Rats | ||
Iranian Journal of Medical Sciences | ||
مقاله 5، دوره 44، شماره 5، آذر 2019، صفحه 397-405 اصل مقاله (1.04 M) | ||
نوع مقاله: Original Article(s) | ||
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44958 | ||
نویسندگان | ||
Asef Hormozi1؛ Asadollah Zarifkar* 2؛ Bahar Rostami1؛ Fakhraddin Naghibalhossaini3 | ||
1Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
2Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
3Department of Biochemistry, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran; and Autoimmune Research Center, Shiraz University of Medical Sciences, School of Medicine, Shiraz, Iran | ||
چکیده | ||
Background: Intense stress can change pain perception and induce hyperalgesia; a phenomenon called stress-induced hyperalgesia (SIH). However, the neurobiological mechanism of this effect remains unclear. The present study aimed to investigate the effect of the spinal cord µ-opioid receptors (MOR) and α2-adrenergic receptors (α2-AR) on pain sensation in rats with SIH. Methods: Eighteen Sprague-Dawley male rats, weighing 200-250 g, were randomly divided into two groups (n=9 per group), namely the control and stress group. The stress group was evoked by random 1-hour daily foot-shock stress (0.8 mA for 10 seconds, 1 minute apart) for 3 weeks using a communication box. The tail-flick and formalin tests were performed in both groups on day 22. The real-time RT-PCR technique was used to observe MOR and α2-AR mRNA levels at the L4-L5 lumbar spinal cord. Statistical analysis was performed using the GraphPad Prism 5 software (San Diego, CA, USA). Student’s t test was applied for comparisons between the groups. P | ||
کلیدواژهها | ||
Stress؛ Hyperalgesia؛ Spinal cord؛ Receptors, opioid, mu؛ Adrenergic alpha-2 receptor antagonists | ||
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