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Sadeghi, Alireza, Nejati, Maliheh, Moghaddas, Azadeh. (1398). A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis. سامانه مدیریت نشریات علمی, 44(4), 342-346. doi: 10.30476/ijms.2019.44953
Alireza Sadeghi; Maliheh Nejati; Azadeh Moghaddas. "A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis". سامانه مدیریت نشریات علمی, 44, 4, 1398, 342-346. doi: 10.30476/ijms.2019.44953
Sadeghi, Alireza, Nejati, Maliheh, Moghaddas, Azadeh. (1398). 'A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis', سامانه مدیریت نشریات علمی, 44(4), pp. 342-346. doi: 10.30476/ijms.2019.44953
Sadeghi, Alireza, Nejati, Maliheh, Moghaddas, Azadeh. A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis. سامانه مدیریت نشریات علمی, 1398; 44(4): 342-346. doi: 10.30476/ijms.2019.44953

A Rare Presentation of Multiple Myeloma: A Case Report of Hepatic Amyloidosis

Iranian Journal of Medical Sciences
مقاله 9، دوره 44، شماره 4، مهر 2019، صفحه 342-346    اصل مقاله (571.9 K)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2019.44953
نویسندگان
Alireza Sadeghi1؛ Maliheh Nejati2؛ Azadeh Moghaddas* 3
1Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Clinical Pharmacy, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Amyloidosis, defined as a tissue deposition of clonal light-chain fibrils, has been reported in 10-15% of the MM patients. We described a rare MM patient with the primal presentation of fulminant hepatic failure and biliary system involvement due to amyloidosis. Our patient had the primal symptoms of hyperbilirubinemia, ascites, hepatosplenomegaly, and anemia. Chemotherapy with a standard regimen containing bortezomib, thalidomide, and dexamethasone was implemented and led to a dramatic response. Liver involvement due to light chain amyloidosis can be the first drastic presentation of MM. It is important to consider infiltrative disorders, like MM and amyloidosis, when patients present non-specific symptoms and impaired liver function tests. Proper and timely diagnosis can directly affect the prognosis of patients. The optimal approach in the standard management of similar cases is still a matter of debate.
کلیدواژه‌ها
Liver failure؛ Multiple myeloma؛ Amyloidosis؛ Hyperbilirubinemia
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