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Tarokh, Majid, Ghaffari Novin, Marefat, Poordast, Tahereh, Tavana, Zohreh, Nazarian, Hamid, Norouzian, Mohsen, Gharesi-Fard, Behrouz. (1398). Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis. سامانه مدیریت نشریات علمی, 16(2), 151-162. doi: 10.22034/iji.2019.80258
Majid Tarokh; Marefat Ghaffari Novin; Tahereh Poordast; Zohreh Tavana; Hamid Nazarian; Mohsen Norouzian; Behrouz Gharesi-Fard. "Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis". سامانه مدیریت نشریات علمی, 16, 2, 1398, 151-162. doi: 10.22034/iji.2019.80258
Tarokh, Majid, Ghaffari Novin, Marefat, Poordast, Tahereh, Tavana, Zohreh, Nazarian, Hamid, Norouzian, Mohsen, Gharesi-Fard, Behrouz. (1398). 'Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis', سامانه مدیریت نشریات علمی, 16(2), pp. 151-162. doi: 10.22034/iji.2019.80258
Tarokh, Majid, Ghaffari Novin, Marefat, Poordast, Tahereh, Tavana, Zohreh, Nazarian, Hamid, Norouzian, Mohsen, Gharesi-Fard, Behrouz. Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis. سامانه مدیریت نشریات علمی, 1398; 16(2): 151-162. doi: 10.22034/iji.2019.80258

Serum and Peritoneal Fluid Cytokine Profiles in Infertile Women with Endometriosis

Iranian Journal of Immunology
مقاله 6، دوره 16، شماره 2، شهریور 2019، صفحه 151-162    اصل مقاله (772.4 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80258
نویسندگان
Majid Tarokh1؛ Marefat Ghaffari Novin* 1؛ Tahereh Poordast2، 3؛ Zohreh Tavana2، 3؛ Hamid Nazarian1؛ Mohsen Norouzian1؛ Behrouz Gharesi-Fard* 3، 4، 5
1Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Immunology Department, Shiraz university of Medical Sciences, Shiraz, Iran
5Department of reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Endometriosis is a chronic inflammatory disease with the growth of endometrial cells out of uterus and in the peritoneal cavity. T cell subsets participate in the establishment and progress of the disease by producing different cytokines. Objective: To investigate a group of cytokines related to Th1/Th2/Th17/Treg subsets within both peripheral blood and peritoneal fluid (PF) samples from infertile endometriosis women. Methods: Peripheral blood and PF samples were collected from 30 infertile endometriosis and 30 non-endometriosis fertile women during laparoscopy. Concentration of cytokines, including TNF-α, IFN-γ, TGF-β1, IL-4, IL-10, IL-17 and IL- 23 were evaluated using ELISA method. Results: Results indicated that the concentration of IFN-γ within serum was significantly reduced in endometriosis group (p=0.001). Regarding PF cytokines, TGF-β1 was increased in endometriosis group (p=0.030). Furthermore, the ratios of IFN-γ/TGF-β1 and IL-17/IL-23 were significantly different between endometriosis and non-endometriosis women in serum samples (pConclusion: Based on the results of the present study, in women with endometriosis, the disturbance of cytokines network might gradually activate the inflammatory responses and tissue repair, resulting in endometriosis development after several years.
کلیدواژه‌ها
Cytokines؛ Endometriosis؛ Infertility؛ T Cell Subsets
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