LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,113
تعداد مقالات10,208
تعداد مشاهده مقاله40,780,102
تعداد دریافت فایل اصل مقاله8,803,917
Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. (1398). CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. سامانه مدیریت نشریات علمی, 16(2), 142-150. doi: 10.22034/iji.2019.80257
Shohreh Fakhari; Hamed Bashiri; Bayazid Ghaderi; Kaveh Tari; Ali Jalili. "CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes". سامانه مدیریت نشریات علمی, 16, 2, 1398, 142-150. doi: 10.22034/iji.2019.80257
Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. (1398). 'CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes', سامانه مدیریت نشریات علمی, 16(2), pp. 142-150. doi: 10.22034/iji.2019.80257
Fakhari, Shohreh, Bashiri, Hamed, Ghaderi, Bayazid, Tari, Kaveh, Jalili, Ali. CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. سامانه مدیریت نشریات علمی, 1398; 16(2): 142-150. doi: 10.22034/iji.2019.80257

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes

Iranian Journal of Immunology
مقاله 5، دوره 16، شماره 2، شهریور 2019، صفحه 142-150    اصل مقاله (922.74 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80257
نویسندگان
Shohreh Fakhari1، 2؛ Hamed Bashiri1؛ Bayazid Ghaderi1؛ Kaveh Tari1؛ Ali Jalili* 1، 2
1Cancer and Immunology Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
2Department of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
چکیده
Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investigate the expression of CD93 on multiple myeloma (MM) cells. Methods: Human MM and B cell lines were cultured, and the expression of CD93 was examined on these cells by quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) and Fluorescence Activated Cell Sorting (FACS). In addition, CD19+ primary B cells and CD19-/CD138+ primary MM cells were isolated by MACS columns, and CD93 expression was further analyzed on these cells. Results: qRT-PCR data showed that CD93 expression at mRNA level was much higher in MM cell lines compared with B cell lines. In addition, MM cell lines expressed a higher amount of surface CD93 at protein level compared with B cell lines. More importantly, CD93 expression was significantly higher in CD19-/CD138+ primary MM cells than in CD19+ primary B cells isolated from the bone marrow of patients with MM. Conclusion: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role.
کلیدواژه‌ها
C1q؛ CD93؛ Multiple Myeloma
آمار
تعداد مشاهده مقاله: 2,148
تعداد دریافت فایل اصل مقاله: 1,261


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب