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Hossein-Nataj, Hadi, Masjedi, Mohsen, Emami, Mohammad Hassan, Mokhtari, Mojgan, Alsahebfosoul, Fereshteh. (1398). Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients. سامانه مدیریت نشریات علمی, 16(2), 117-126. doi: 10.22034/iji.2019.80255
Hadi Hossein-Nataj; Mohsen Masjedi; Mohammad Hassan Emami; Mojgan Mokhtari; Fereshteh Alsahebfosoul. "Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients". سامانه مدیریت نشریات علمی, 16, 2, 1398, 117-126. doi: 10.22034/iji.2019.80255
Hossein-Nataj, Hadi, Masjedi, Mohsen, Emami, Mohammad Hassan, Mokhtari, Mojgan, Alsahebfosoul, Fereshteh. (1398). 'Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients', سامانه مدیریت نشریات علمی, 16(2), pp. 117-126. doi: 10.22034/iji.2019.80255
Hossein-Nataj, Hadi, Masjedi, Mohsen, Emami, Mohammad Hassan, Mokhtari, Mojgan, Alsahebfosoul, Fereshteh. Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients. سامانه مدیریت نشریات علمی, 1398; 16(2): 117-126. doi: 10.22034/iji.2019.80255

Cell Density Counts of the Intestinal Intraepithelial Lymphocytes in the Celiac Patients

Iranian Journal of Immunology
مقاله 3، دوره 16، شماره 2، شهریور 2019، صفحه 117-126    اصل مقاله (745.6 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2019.80255
نویسندگان
Hadi Hossein-Nataj1؛ Mohsen Masjedi* 2؛ Mohammad Hassan Emami3؛ Mojgan Mokhtari4؛ Fereshteh Alsahebfosoul2
1Department of Immunology, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran
3Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Increased number of intestinal intraepithelial lymphocytes (IELs) is a key histological finding in the diagnosis of celiac disease (CD); however, the number of IELs in celiac patients and healthy subjects may vary from one region to another. Additionally, there are some seronegative celiac patients with a borderline histology. Objective: To determine the number of the CD3+ and CD8+ IELs T-cells in the celiac patients and healthy subjects (controls) in Isfahan. Methods: The duodenal biopsies were obtained from the celiac patients (n=15) and the controls (n=19). The total number of IELs/100 epithelial cells (ECs) were counted using the hematoxylin-eosin (H&E) staining method, and that of CD3+ and CD8+ IELs/100 ECs were counted using the immunohistochemistry (IHC) staining method. Results: This study defined the upper normal limit for each variable as mean + 2SD. Accordingly, the upper normal limits of the total IELs, CD3+ IELs, and CD8+  IELs/100 ECs were calculated as 37 (95% confidence intervals, CI: 33–41), 22 (95% CI: 19–25) and 12 (95% CI: 10–14), respectively. In 3 clinically CD diagnoses, the total IELs counts/100 ECs were below the upper normal limit, and the histopathological and serologic assays were negative. Nevertheless, the CD8+ IELs T-cells counts/100 ECs showed borderline values. Interestingly, these patients responded to a gluten-free diet (GFD). Conclusions: The study findings suggest that in the clinically diagnosed celiac disease, IELs count/100 ECs below the upper normal limit as well as negative histopathological and serologic assays and the cell density counts of the CD8+ IELs T-cells/100 ECs could be a useful parameter for CD diagnosis and make a decision to put them on a GFD.
کلیدواژه‌ها
Celiac Disease؛ Diagnosis, Gut, Intraepithelial Lymphocytes
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