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Comparative Study of Punica granatum Gel and Triadent Oral Paste Effect on Recurrent Aphthous Stomatitis, a Double Blind Clinical Trial | ||
| Journal of Dentistry | ||
| مقاله 7، دوره 20، شماره 3 - شماره پیاپی 64، آذر 2019، صفحه 184-189 اصل مقاله (221.53 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2019.44913 | ||
| نویسندگان | ||
| Atefeh Tavangar* 1؛ Abolfazl Aslani2؛ Niloofar Nikbakht3 | ||
| 1Dental Material Research Center, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| 2Dept of Pharmacognosy, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. | ||
| 3Dentis, Isfahan, Iran. | ||
| چکیده | ||
| Statement of the Problem: Recurrent aphthous stomatitis is a common oral lesion, and the use of herbal remedies containing tannin and flavonoid has been reported to be effective in treating aphthous stomatitis. Purpose: This study was aimed to evaluate the effect of Punica granatum muco-adhesive gel on controlling the oral recurrent aphthous stomatitis and its comparison with Triadent oral paste. Materials and Method: In this double-blind clinical trial, 60 patients with minor aphthous stomatitis were enrolled. These patients had no systemic diseases and were not on any medications. The patients were randomly treated with Punica granatum formulated gel, Triadent oral paste and placebo. The time of pain elimination and the time of complete healing were recorded and the pain degree was assessed and recorded by each patient. The data were analyzed using survival analysis and ANOVA test. Results: The Kaplan-Meier survival analysis demonstrated that pain relief time in Punica granatum group was lower than placebo group (p = 0.002), even so, it caused no significant difference with the Triadent group in comparison with the placebo group (p = 0.08). The survival analysis also indicated that the wound healing time in Punica granatum group was significantly lower than the other two groups (p < 0.05). Conclusion: Punica granatum gel has a successful effect in controlling and treating recurrent aphthous stomatitis. It can be considered as an affordable and inexpensive treatment. | ||
| کلیدواژه‌ها | ||
| Aphthous ● Triadentent ● Pain ● Punicagranatum ● Stomatitis ● Management | ||
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| مراجع | ||
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1. Vincent SD, Lilly GE. Clinical, historic, and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids. Oral Surg Oral Med Oral Pathol. 1992; 74: 79–86. [PubMed] [Google Scholar]
2. Burket LW, Greenberg MS, Glick M. Burket's oral medicine: diagnosis & treatment. 12th ed. Hamilton : BcDecker ; 2015. pp. 73–77. [Google Scholar]
3. Khademi H, Khozeimeh F, Tavangar A, Amini S, Ghalayani P. The Serum and salivary level of malondialdehyde, vitamins A, E, and C in patient with recurrent aphthous stomatitis. Adv Biomed Res. 2014; 3: 246. [PMC free article] [PubMed] [Google Scholar]
4. Athani N, Ravikumar H, Kallalli B, Chopra S. Management of Recurrent Aphthous Stomatitis with Chlorhexidine gluconate Mouthwash and Vitamin B-Complex. Pakistan Oral & Dental Journal. 2012; 32: 214–217. [Google Scholar]
5. Deshmukh RA, Bagewadi AS. Comparison of effectiveness of curcumin with triamcinolone acetonide in the gel form in treatment of minor recurrent aphthous stomatitis: A randomized clinical trial. Int J Pharm Investig. 2014; 4: 138–141. [PMC free article] [PubMed] [Google Scholar]
6. Gavanji S, Larki B, Bakhtari A. The effect of extract of Punicagranatum var. pleniflora for treatment of minor recurrent aphthous stomatitis. Integr Med Res. 2014; 3: 83–90. [PMC free article] [PubMed] [Google Scholar]
7. Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. J Oral Pathol Med. 2014; 43: 405–409. [PubMed] [Google Scholar]
8. Ghalayani P, Zolfaghary B, Farhad AR, Tavangar A, Soleymani B. The efficacy of Punicagranatum extract in the management of recurrent aphthous stomatitis. J Res Pharm Pract. 2013; 2: 88–92. [PMC free article] [PubMed] [Google Scholar]
9. Jahanshahi G, Saniei M. A pilot study to evaluate the efficacy of mucoadhesive (Aphtogel) in the treatment of oral minor aphthous ulcers. Journal of Isfahan Dental School. 2011; 7: 619–627. [Google Scholar]
10. Khademi H, Iranmanesh P, Moeini A, Tavangar A. Evaluation of the Effectiveness of the Iralvex Gel on the Recurrent Aphthous Stomatitis Management. IntSch Res Notices. 2014; 2014: 175378. [PMC free article] [PubMed] [Google Scholar]
11. EslamiRaveshty S, EslamiRaveshty S. The Effect of Combining Essences of MyrtusCommunis and Melissa Officinalis in the Treatment of Minor Aphta. ZUMSJ. 2011; 19: 77–83. [Google Scholar]
12. Jafari S, Amanlou M, Borhan-mojabi K, Farsam H. Comparartive study of Zatariamultiflora and Anthemisnobelis extracts with Myrthus communis preparation in the treatment of recurrent aphthous stomatitis. DARU Journal of Pharmaceutical Sciences. 2003; 11: 23–27. [Google Scholar]
13. Motallebnejad M, Moghadamnia A, Talei M. The efficacy of Hypericum perforatum extract on recurrent aphthous ulcers. J Med Sci. 2008; 8: 39–43. [Google Scholar]
14. Amanlou M, Farsam H, Babaei N, Saheb JM, Tohi DAZ, Salehnia A. Efficacy of Saturejakhuzistanica extract and its essential oil preparations in the management of recurrent aphthous stomatitis. DARU. 2007; 15: 231–235. [Google Scholar]
15. Aslani A, Zolfaghari B, Davoodvandi F. Design,formulation and evaluation of an oral gel from punica granatum flower extract for treatment of recurrent aphthous stomatitis. Adv Pharm Bull. 2016; 6: 391–398. [PMC free article] [PubMed] [Google Scholar]
16. Wang R, Wei W, Wang L, Liu R, Yi D, Du L. Constituents of the flowers of Punica granatum. Fitoterapia. 2006; 77:534–537. [PubMed] [Google Scholar]
17. Sudheesh S, Vijayalakshmi NR. Flavonoids from Punicagranatum--potential antiperoxidative agents. Fitoterapia. 2005; 76: 181–186. [PubMed] [Google Scholar]
18. Costantini S, Rusolo F, De Vito, V Moccia, S Picariello, G Capone, F et. Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punicagranatum L.) seed oil on breast cancer cell lines. Molecules. 2014; 19: 8644–8660. [PMC free article] [PubMed] [Google Scholar]
19. Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000; 52: 673–751. [PubMed] [Google Scholar]
20. Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centellaasiatica and Punica granatum extracts. A preliminary study. J IntAcadPeriodontol . 2003; 5: 106–115. [PubMed] [Google Scholar]
21. Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punicagranatum L. Planta Med. 2007; 73: 461–467. [PubMed] [Google Scholar]
22. Li Y, Ooi LS, Wang H, But PP, Ooi VE. Antiviral activities of medicinal herbs traditionally used in southern mainland China. Phytother Res. 2004; 18: 718–722. [PubMed] [Google Scholar]
23. Braga LC, Shupp JW, Cummings C, Jett M, Takahashi JA, Carmo LS, et al. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotox in production. J Ethnopharmacol. 2005; 96: 335–339. [PubMed] [Google Scholar]
24. Pirbalouti AG, Koohpayeh A, Karimi I. The wound healing activity of flower extracts of Punica granatum and Achilleakellalensis in Wistar rats. Acta Pol Pharm. 2010; 67: 107–110. [PubMed] [Google Scholar]
25. Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferationandprocollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006; 103: 311–318. [PubMed] [Google Scholar]
26. Boras VV, Lukac J, Brailo V, Picek P, Kordić D, Zilić IA. Salivary interleukin-6 and tumor necrosis factor-alpha in patients with recurrent aphthous ulceration. J Oral Pathol Med. 2006; 35: 241–243. [PubMed] [Google Scholar]
27. Borhani Haghighi A, Bagheri M. Pomegranate juice may be a potential addition to anti-Behcet armamentarium: a hypothesis. Clin Rheumatol. 2007; 26: 1709–1710. [PubMed] [Google Scholar] | ||
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